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Neuronal cell death and nerve regeneration in the nerve-resected rats

Research Project

Project/Area Number 18K06825
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 48010:Anatomy-related
Research InstitutionShinshu University

Principal Investigator

Fukushima Nanae  信州大学, 学術研究院医学系, 教授 (90334888)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords神経欠損 / 神経細胞死 / 神経再生
Outline of Final Research Achievements

We investigated neuronal cell death and nerve regeneration after the varying degrees of resection of the XII nerve in adult rats. Total number of XII neurons decreased after nerve resection and the survival rates of XII neurons were related to distances between resected nerve stamps. Moreover, the number of XII neurons after extensive XII nerve resection declined gradually over a relatively long time period. Furthermore, by injection of retrograde tracer into the tongue after nerve resection, the possibility was suggested that spontaneous neural regeneration occur after nerve resection with a relatively long gap.

Academic Significance and Societal Importance of the Research Achievements

神経損傷および損傷後の再生に関する研究は、様々な神経系を対象として数多く行われている。しかし、その多くは圧迫損傷や切断に関する実験が多く、実際の神経損傷時に高頻度で起こりうる損傷である神経欠損に関する研究は少ない。本研究は、神経欠損により軸索を損傷されたニューロンの細胞死や神経欠損後の神経線維の再生について、損傷の程度(欠損した神経の長さ)と関連させて評価を行った研究であり、本研究の結果は神経欠損後の神経再生に向けた基礎的データとして非常に重要である。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (6 results)

All 2021 2020 2019

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results)

  • [Journal Article] Spontaneous regeneration after hypoglossal nerve injury with long nerve resection in rats2021

    • Author(s)
      Fukushima N, Sumitomo N, Nagira A, Ichinose Y, Kakegawa A
    • Journal Title

      Neurophysiology

      Volume: -

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoglossal nerve injury with long nerve resection leading to slow motoneuron death2020

    • Author(s)
      Fukushima N, Kobayashi T, Kakegawa A, Sumitomo N, Nagira A, Moriizumi T
    • Journal Title

      Neuroscience Letters

      Volume: 715 Pages: 134668-134668

    • DOI

      10.1016/j.neulet.2019.134668

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of various lengths of hypoglossal nerve resection on motoneuron survival2019

    • Author(s)
      Karasawa Mika、Yokouchi Kumiko、Kawagishi Kyutaro、Moriizumi Tetsuji、Fukushima Nanae
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: 60 Pages: 128-131

    • DOI

      10.1016/j.jocn.2018.11.020

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 舌下神経切除が運動ニューロン細胞死に与える影響について2021

    • Author(s)
      福島菜奈恵、住友憲深、柳樂彩太、一之瀬優子、掛川晃
    • Organizer
      第126回日本解剖学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 神経切除後のニューロン細胞死-切除幅と生存率-2020

    • Author(s)
      福島菜奈恵、住友憲深、柳樂彩太、掛川晃、森泉哲次
    • Organizer
      第125回日本解剖学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 舌下神経切除後のニューロン細胞死2019

    • Author(s)
      福島 菜奈恵、小林 竜哉、横内 久美子、森泉 哲次
    • Organizer
      第124回日本解剖学会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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