| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
The regulators of planar cell polarity (PCP) are known to control closure of the developing neural tube and orientation of the cochlear hair cell epithelia. Studying molecular mechanisms of synaptogenesis, my research group has found that one of the PCP protein Vangl2 interacts N-cadherin to control synaptic cell-cell adhesion. To address if this molecular mechanism is generally adopted in the PCP development, we bred the mutant mice of the two genes and found that the digenic heterozygotes were with spina bifida and abnormal orientation of cochlear epithelia.
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