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Regulatory mechanism of angiogenesis mediated by calcium signaling

Research Project

Project/Area Number 18K06867
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 48020:Physiology-related
Research InstitutionWakayama Medical University (2019-2021)
National Cardiovascular Center Research Institute (2018)

Principal Investigator

Nishitani Tomoe  和歌山県立医科大学, 医学部, 教授 (50393244)

Co-Investigator(Kenkyū-buntansha) 中川 修  国立研究開発法人国立循環器病研究センター, 研究所, 部長 (40283593)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords血管形成 / カルシウムシグナル / Tmem100 / TRP チャネル / 低酸素 / イオンチャネル / メカノセンサー / カルシウム / メカニカルストレス
Outline of Final Research Achievements

Angiogenesis is an essential process for organogenesis and wound healing. Recently, the importance of intracellular Ca2+ signaling in the process of angiogenesis has been suggested. We have identified Tmem100 as a essential factor for cardiovascular angiogenesis and found that intracellular Ca2+ signaling is involved in its function. In the present study, we investigated the relationship between Tmem100 and various intracellular Ca2+ signal regulators. We found that TRPV4 channels, which play an important role in endothelial functions, physically interact with Tmem100 and co-localize with it in vascular endothelial cells, whereas TRPC6 channels, which are important for vascular smooth muscle, do not bind

Academic Significance and Societal Importance of the Research Achievements

心血管形成機構に関しては、これまで転写因子活性化シグナルの解明に焦点が絞られてきたが、細胞内Ca2+シグナルの重要性を示す研究は未だ新規である。今回、Tmem100とメカノセンサーとして働くTRPチャネルとの機能連関および心血管形成における寄与を証明できれば、①Tmem100のイオンチャネル分子内制御因子としての新規分子機能、②TRPチャネルの心血管形成における重要性、③他の関連因子も含めたCa2+シグナルを介した心血管形成機構の重要性が明らかになり、薬物開発の新たなターゲット探索になる。総じて、ヒト疾患の病因解明・治療法の開発に向けた基礎研究として現代社会に大いに役立つことが期待できる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (22 results)

All 2022 2021 2020 2019 2018

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (17 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results)

  • [Journal Article] Chemogenetic activation of central gastrin-releasing peptide-expressing neurons elicits itch-related scratching behavior in male and female mice Pharmacology Research and Perspective2021

    • Author(s)
      Norikazu Kiguchi, Yohji Fukazawa, Ayano Saika, Daisuke Uta, Fumihiro Saika, Tomoe Y. Nakamura, Mei-Chuan Ko, Shiroh Kishioka
    • Journal Title

      Pharmacology Research and Perspective

      Volume: - Issue: 3 Pages: 1-11

    • DOI

      10.1002/prp2.790

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel Ca<sup>2+</sup> regulatory mechanism specific for immature hearts and its potential as a therapeutic target2021

    • Author(s)
      西谷(中村)友重
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 156 Issue: 6 Pages: 346-350

    • DOI

      10.1254/fpj.21056

    • NAID

      130008109931

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2021 Annual Research Report
  • [Journal Article] 興奮性細胞における新規Ca2+シグナル制御因子NCS-1の多彩な生理機能と各種疾患との関連2021

    • Author(s)
      西谷(中村)友重
    • Journal Title

      和歌山医学

      Volume: 72 Pages: 192-197

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Chemogenetic Regulation of CX3CR1-Expressing Microglia Using Gi-DREADD Exerts Sex-Dependent Anti-Allodynic Effects in Mouse Models of Neuropathic Pain2020

    • Author(s)
      Fumihiro Saika, Shinsuke Matsuzaki, Daichi Kobayashi, Yuya Ideguchi, Tomoe Y Nakamura, Shiroh Kishioka, Norikazu Kiguchi
    • Journal Title

      Frontiers in Pharmacology

      Volume: 11 Pages: 925-925

    • DOI

      10.3389/fphar.2020.00925

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Emerging roles of neuronal Ca2+ sensor-1 in cardiac and neuronal tissues: a mini review2019

    • Author(s)
      Nakamura TY., Nakao S, Wakabayashi S
    • Journal Title

      Frontiers in Molecular Neuroscience

      Volume: 12 Pages: 56-56

    • DOI

      10.3389/fnmol.2019.00056

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] GIRKチャネルとその疾患関連変異体への新規作用薬の同定2022

    • Author(s)
      陳以珊, 西谷友重
    • Organizer
      第95回日本薬理学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] タバコ煙抽出液が成熟および新生子心筋細胞の収縮、自動拍動および細胞内Ca2+動態に及ぼす影響2022

    • Author(s)
      安田純平, 松村早季子, 石村洋輝, 長洲弘真, 西谷(中村)友重
    • Organizer
      第95回日本薬理学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 細胞内Ca2+調節因子NCS-1の興奮性組織における多彩な生理機能2022

    • Author(s)
      西谷(中村)友重
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] A novel Ca2+ regulatory mechanism specific for immature heart function, and its potential as a therapeutic target2021

    • Author(s)
      Tomoe Nishitani
    • Organizer
      The 1st International Symposium for Postgraduates on Basic Medical Sciences
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Novel therapeutic targets for heart diseases that regulate the immature heart-specific intracellular Ca2+ signaling pathways2021

    • Author(s)
      Tomoe Y. Nakamura-Nishitani
    • Organizer
      第94回日本薬理学会年会
    • Related Report
      2020 Research-status Report
  • [Presentation] Gi/Gq DREADDを用いた脊髄ミクログリアの操作による性依存的な疼痛制御機構2021

    • Author(s)
      雑賀 史浩、木口 倫一、松崎 伸介、西谷-中村 友重
    • Organizer
      第94回日本薬理学会年会
    • Related Report
      2020 Research-status Report
  • [Presentation] 細胞内Ca2+シグナルを介した新規エネルギー代謝制御機構2021

    • Author(s)
      中尾 周, 松村 早奇子,若林 繁夫1,中村(西谷) 友重
    • Organizer
      第98回日本生理学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 痒みの発現におけるGRP産生ニューロンの役割2020

    • Author(s)
      雑賀 彩乃,木口 倫一,深澤 洋滋,雑賀 史浩,西谷 友重
    • Organizer
      第138回 日本薬理学会近畿支部会
    • Related Report
      2020 Research-status Report
  • [Presentation] A novel regulatory mechanism of energy metabolism mediated by Neuronal calcium sensor-1 and its relation to exercise therapies2020

    • Author(s)
      Tomoe Nakamura-Nishitani, Shu Nakao, Hirotsugu Tsuchimochi, James Pearson, Shigeo Wakabayashi
    • Organizer
      第97回 日本生理学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Regulation of mitochondrial respiration, energy metabolism, and obesity by Neuronal Ca2+ Sensor-12019

    • Author(s)
      Tomoe Y.Nakamura-Nishitani, Shu Nakao, Shigeo Wakabayashi
    • Organizer
      第96回 日本生理学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] カルシウムシグナル調節因子NCS-1欠損によるエネルギー代謝異常と運動療法の効果2019

    • Author(s)
      中村(西谷)友重, 中尾 周, 土持 裕胤, ピアソン ジェームス, 若林繁夫
    • Organizer
      第112回近畿生理学談話会
    • Related Report
      2019 Research-status Report
  • [Presentation] Regulation of mitochondorial respiration, energy metabolism, and obesity by neuronal Ca2+ sensor-12019

    • Author(s)
      35.Tomoe Y. Nakamura-Nishitani, Shu Nakao, Shigeo Wakabayashi
    • Organizer
      9thFAOPS congress
    • Related Report
      2018 Research-status Report
  • [Presentation] Significance of the Hey family of transcription factors during cardiovascular development2018

    • Author(s)
      Yusuke WATANABE, Shuhei ISHII, Taiki UEMOTO, Tomoe NAKAMURA-NISHITANI, Daiki SEYA, Dai IHARA, Teruhisa KAWAMURA, Osamu NAKAGAWA
    • Organizer
      International Vascular Biology Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Significance of Hey transcriptional factors in endothelial cells during cardiovascular development2018

    • Author(s)
      Yusuke WATANABE, Tomoe NAKAMURA-NISHITANI, Daiki SEYA, Dai IHARA, Teruhisa KAWAMURA, Osamu NAKAGAWA
    • Organizer
      日本血管生物医学会 第16回Korea-Japan Joint Symposium
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Significance of Hey transcriptional factors in endothelial cells during cardiovascular development2018

    • Author(s)
      Yusuke WATANABE, Tomoe NAKAMURA-NISHITANI, Daiki SEYA, Dai IHARA, Teruhisa KAWAMURA, Osamu NAKAGAWA
    • Organizer
      日本循環器学会第2回 Basic Cardiovascular Research Conference
    • Related Report
      2018 Research-status Report
  • [Presentation] Transcriptional regulation and physiological significance of BMP-ALK1 signal target genes in embryonic vascular endothelial cell2018

    • Author(s)
      Osamu NAKAGAWA, Yusuke WATANABE, Yumi KINUGASA-KATAYAMA, Tomoe NAKAMURA-NISHITANI, Yukihiro HARADA, Norika Liu, Toru TANAKA, Daiki SEYA, Dai IHARA, Teruhisa KAWAMURA
    • Organizer
      12th International BMP Conference 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Hey転写調節因子ファミリーの胎生期血管形成における細胞特異的意義の解析2018

    • Author(s)
      西谷-中村友重、渡邉裕介、瀬谷大貴、田中亨、中川修
    • Organizer
      第26回日本血管生物医学会学術集会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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