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Neuronal mechanism regulating the respiratory rhythm by the visceral sensory information

Research Project

Project/Area Number 18K06874
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 48020:Physiology-related
Research InstitutionShimane University

Principal Investigator

HAMA Noriyuki  島根大学, 学術研究院医学・看護学系, 助教 (60422010)

Co-Investigator(Kenkyū-buntansha) 横田 茂文  島根大学, 学術研究院医学・看護学系, 准教授 (50294369)
伊藤 眞一  島根大学, 医学部, 特別協力研究員 (10145295)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords呼吸リズム / 経血管灌流標本 / 孤束核 / 光遺伝学 / 弧束核
Outline of Final Research Achievements

We analyzed the alternation in the respiratory rhythm induced by the activation of inhibitory and excitatory neurons in the nucleus of solitary tract, the relay nucleus of visceral sensory information. The results revealed that inhibitory neurons terminated inspiration by suppressing the activity of respiratory pacemaker neurons, which also play as an inspiratory neurons, and excitatory neurons activated the expiratory neurons.

Academic Significance and Societal Importance of the Research Achievements

呼吸は生命維持に不可欠な運動であり,その調節機構は不明な点が多い。体液のpHや肺の伸展状態といった臓器感覚による調節は重要な調節因子の一つである。これらの臓器感覚の中継核である孤束核の抑制性ニューロンや興奮性ニューロンによる呼吸調節機構を明らかにした。これにより,睡眠時無呼吸症候群といった呼吸調節機構に異常に起因する疾患の病態理解や治療法の開発に基礎的知見を提供することが期待できる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (32 results)

All 2022 2021 2020 2019 2018

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results) Presentation (26 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Coherence analysis of the calcium activity of putative astrocytic and neuronal cells on the L5 ventral horn and neural output in activated lumbar CPG networks2022

    • Author(s)
      Yazawa Itaru、Okazaki Shuntaro、Yokota Shigefumi、Takeda Kotaro、Fukushi Isato、Yoshizawa Masashi、Onimaru Hiroshi、Okada Yasumasa
    • Journal Title

      Neuroscience Letters

      Volume: 771 Pages: 136421-136421

    • DOI

      10.1016/j.neulet.2021.136421

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optical Analysis of Acute Changes after Peripheral Nerve Injury in Spatio-Temporal Pattern of Neural Response to Forelimb Stimulation in Rat Somatosensory Cortex2020

    • Author(s)
      Hama Noriyuki、Kawai Minako、Ito Shin-Ichi、Hirota Akihiko
    • Journal Title

      Neuroscience

      Volume: 448 Pages: 85-93

    • DOI

      10.1016/j.neuroscience.2020.09.020

    • NAID

      120007163833

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Concave-shaped transparent electrode to simultaneously monitor electrical activity from multiple sites within the optical sampling area of the intact rat cerebral cortex2019

    • Author(s)
      Hama Noriyuki、Kawai Minako、Ito Shin-ichi、Yoshida Yuki、Fujita Yasuhisa、Hirota Akihiko
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 69 Issue: 3 Pages: 543-551

    • DOI

      10.1007/s12576-019-00663-y

    • NAID

      40021874334

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lateral parabrachial neurons innervate orexin neurons projecting to brainstem arousal areas in the rat2019

    • Author(s)
      Yosuke Arima, Shigefumi Yokota, Masashi Fujitani
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 2830-2830

    • DOI

      10.1038/s41598-019-39063-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] New nociceptive circuits to the hypothalamic perifornical area from the spinal cord and spinal trigeminal nucleus via the parabrachial nucleus2019

    • Author(s)
      Hirohiko Asano, Yosuke Arima, Shigefumi Yokota, Masashi Fujitani
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 512 Issue: 4 Pages: 705-711

    • DOI

      10.1016/j.bbrc.2019.02.153

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Structural and functional identification of two distinct inspiratory neuronal populations at the level of the phrenic nucleus in the rat cervical spinal cord2018

    • Author(s)
      Shinozaki Yoshio、Yokota Shigefumi、Miwakeichi Fumikazu、Pokorski Mieczyslaw、Aoyama Ryoma、Fukuda Kentaro、Yoshida Hideaki、Toyama Yoshiaki、Nakamura Masaya、Okada Yasumasa
    • Journal Title

      Brain Structure and Function

      Volume: 224 Issue: 1 Pages: 57-72

    • DOI

      10.1007/s00429-018-1757-3

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] LINC complex regulates the plasticity of axon initial segment2022

    • Author(s)
      Koichi Hasegawa, Takeshi K Matsui, Junpei Kondo, Shizuka Shoji, Noriyuki Hama, Ken-ichiro Kuwako
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 孤束核抑制性ニューロンによる呼吸調節に関わる神経機構の生理学的・解剖学的解析2021

    • Author(s)
      濱徳行,武田湖太郎,岡田泰昌,越谷直弘,小泉英彦,横田茂文
    • Organizer
      第126回日本解剖学会総会・全国学術集会 第98回日本生理学会大会 合同大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 低酸素が引き起こす呼吸喚起と覚醒の神経路2021

    • Author(s)
      横田茂文, 濱徳行, 武田湖太郎, 岡田泰昌
    • Organizer
      第126回日本解剖学会総会・全国学術集会 第98回日本生理学会大会 合同大会
    • Related Report
      2020 Research-status Report
  • [Presentation] マウス孤束核興奮性ニューロンによる呼吸調節機構の解析2020

    • Author(s)
      濱 徳行,横田 茂文,藤谷 昌司,岡田 泰昌,越谷 直弘,小泉 英彦
    • Organizer
      日本生理学会 第72回中国四国地方会
    • Related Report
      2020 Research-status Report
  • [Presentation] 遺伝子改変動物を用いた孤束核グルタミン酸作動性ニューロンによる呼吸循環調節機構の解析2020

    • Author(s)
      横田茂文, 武田湖太郎, 濱 徳行, 有馬陽介, 藤谷昌司, 岡田泰昌
    • Organizer
      日本生理学会 第72回中国四国地方会
    • Related Report
      2020 Research-status Report
  • [Presentation] 血中低酸素情報を伝達する孤束核から結合腕傍核を介して視床下部へ至る神経路2020

    • Author(s)
      横田茂文、濱 徳行、武田湖太郎、藤谷昌司
    • Organizer
      第125回日本解剖学会総会・全国学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] The pathway transmitting hypoxia information from the solitary nucleus to the hypothalamus2020

    • Author(s)
      Yokota S, Hama N, Takeda K, Fujitani M
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] A dual orexin receptor blocker suvorexant inhibits hypercapnic ventilatory augmentation2020

    • Author(s)
      Fukushi F,Yokota S,Takeda K,Terada J,Okada Y
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Decrease in the expiratory duration induced by the photostimulation of inhibitory neurons within the lateral solitary nucleus during inspiration2020

    • Author(s)
      Hama H Yokota S,Fujitani M,Okada Y, Koshiya N,Koizumi H
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Dual blockade of orexin receptors does not affect ventilation in mice2019

    • Author(s)
      Fukushi I, Yokota S, Takeda K, Terada J, Okada Y
    • Organizer
      The 24th Congress of the Asian Pacific Society of Respirology (APSR 2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dual orexin receptor antagonism and ventilatory function in mice2019

    • Author(s)
      Fukushi I, Yokota S, Takeda K, Terada J, Okada Y
    • Organizer
      The 48th Annual Meeting Society for Neuroscience
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of suvorexant (Belsomra(R)) on ventilation in mice2019

    • Author(s)
      Fukushi I, Yokota S, Takeda K, Okazaki S, Terada J, Okada Y
    • Organizer
      第59回日本呼吸器学会学術講演会
    • Related Report
      2019 Research-status Report
  • [Presentation] Effects of a dual orexin receptor blocker suvorexant on breathing2019

    • Author(s)
      Fukushi I, Yokota S, Takeda K, Terada J, Okada Y
    • Organizer
      第42回神経科学大会
    • Related Report
      2019 Research-status Report
  • [Presentation] The diencephalon augments respiration in the isolated diencephalon-lower brainstem-spinal cord preparations of newborn rats2019

    • Author(s)
      Fukushi I, Kono Y, Yokota S, Takeda K, Yazawa I, Onimaru H, Okada Y
    • Organizer
      The 6th Conference of Japanese Society of Respiratory Physical Therapy
    • Related Report
      2019 Research-status Report
  • [Presentation] ラット外側結合腕傍核は脳幹覚醒調節領域へ投射する視床下部オレキシン産生ニューロンを支配する2019

    • Author(s)
      有馬陽介、横田茂文、藤谷昌司
    • Organizer
      日本解剖学会第74回中国・四国支部学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 孤束核グルタミン酸作動性ニューロンによる呼吸循環調節機構の機能的・形態学的解析2019

    • Author(s)
      横田茂文、武田湖太郎、濱 徳行、有馬陽介、藤谷昌司、岡田泰昌
    • Organizer
      日本解剖学会第74回中国・四国支部学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 孤束核抑制性投射ニューロンによる呼息相の短縮2019

    • Author(s)
      濱 徳行、横田茂文、藤谷昌司、岡田泰昌、越谷直弘、小泉英彦
    • Organizer
      日本生理学会 第71回中国四国地方会
    • Related Report
      2019 Research-status Report
  • [Presentation] Function of inhibitory neurons in the solitary nucleus in the control of respiration2019

    • Author(s)
      Noriyuki Hama, Shigefumi Yokota, Masashi Fujitani, Yasumasa Okada, Naohiro Koshiya, Hidehiko Koizumi
    • Organizer
      9th FAOPS
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 弧束核抑制性ニューロンの光遺伝学的活性化による呼吸リズム修飾2018

    • Author(s)
      濱徳行,横田茂文,藤谷昌司,岡田泰昌,越谷直弘,小泉英彦
    • Organizer
      第41回日本神経科学学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 経血管灌流標本を用いたマウス孤束核抑制性投射ニューロンによる呼吸リズムの修飾機構の解析2018

    • Author(s)
      濱徳行,横田茂文,藤谷昌司,岡田泰昌,越谷直弘,小泉英彦
    • Organizer
      第70回日本生理学会中国四国地方会
    • Related Report
      2018 Research-status Report
  • [Presentation] ラット視床下部背 内側野から延髄腹側循環中枢群に至る神経路の形態学的解析2018

    • Author(s)
      河野洋介,有馬陽介,横田茂文,鬼丸洋,福士勇人,小泉敬一,長谷部洋平,吉沢雅史,喜瀬広亮,戸田孝子,岡田泰昌
    • Organizer
      第41回日本高血圧学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Role of glutamatergic neurons in the caudal solitary nucleus in cardiorespiratory regulation2018

    • Author(s)
      Yokota S, Arima Y, Takeda K, Okada Y
    • Organizer
      第41回神経科学大会
    • Related Report
      2018 Research-status Report
  • [Presentation] The role of the diencephalon in the central control of respiration investigated with the isolated diencephalon-lower brainstem-spinal cord preparation2018

    • Author(s)
      Fukushi I, Kono Y, Yokota S, Takeda K, Okazaki S, Yazawa I, Onimaru H, Okada Y
    • Organizer
      第41回神経科学大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Anatomical connectivity from the dorsomedial hypothalamus to the ventral medullary cardiovascular regions: neural pathway mediating the descending sympathetic information2018

    • Author(s)
      Kono Y, Arima Y, Yokota S, Onimaru H, Fukushi I, Koizumi K, Hasebe Y, Yoshizawa M, Kise H, Hoshiai M, Sugita K, Toda T, Okada Y
    • Organizer
      第41回神経科学大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Lateral parabrachial neurons innervate orexin-containing hypothalamic neurons projecting to the ventral tegmental area and dorsal raphe in the rat2018

    • Author(s)
      Arima Y, Yokota S
    • Organizer
      第41回神経科学大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 視床下部テタヌス刺激は延髄腹側心血管調節領域の遷延性興奮を惹起する: 時空間的解剖2018

    • Author(s)
      河野洋介,岡田泰昌,有馬陽介,福士勇人,小泉敬一,長谷部洋平,吉沢雅史,喜瀬広亮,星合美奈子,杉田完爾,戸田孝子
    • Organizer
      第54回日本小児循環器学会総会・学術集会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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