| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
I evaluated the involvement of histaminergic nervous system in aggressive behaviors in mice. Brain histamine exerts its effect through the regulation of neuron or astrocytes functions. Thus, we investigated the importance of neuronal or astrocytic histamine H1 receptor in aggressive behaviors. Astrocyte-specific deletion of H1 receptor resulted in the increase of attack number in resident-intruder tests, indicating the importance of astrocytes for aggressive behaviors. Next, we used DREADDs (designer receptor exclusively activated by designer drugs) technology to examine the impact of acute histaminergic activation or inhibition on aggression. Acute histaminergic activation led to the enhanced aggressive behaviors. These results confirm the importance of histaminergic nervous system for the regulation of aggressive behaviors.
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