Investigation of molecular devices for oxytocin transport into the brain

• Project/Area Number: 18K06889
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 48030:Pharmacology-related
• Research Institution: Kanazawa University
• Principal Investigator: Yamamoto Yasuhiko 金沢大学, 医学系, 教授 (20313637)
• Co-Investigator(Kenkyū-buntansha): 棟居 聖一 金沢大学, 医学系, 助教 (10399040) ; 原島 愛 金沢大学, 医学系, 助教 (50705522)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: オキシトシン / 血液脳関門 / RAGE / 子育て / 愛情

Outline of Final Research Achievements

Oxytocin (OT) is a neuropeptide hormone and is released into circulation from the posterior pituitary. Circulating OT has a prominent hormonal role in female reproduction. OT also acts as a chemical messenger and has been shown to be important in human behaviors such as sexual arousal, recognition, trust, anxiety, and mother-infant bonding. For OT to exert its function, it must pass from the circulatory system through the blood-brain barrier portion of the neurovascular unit into the brain. There has been no direct evidence for this oxytocin transport process and for molecular mechanisms underlying the process. However, this study has demonstrated that the receptor for advanced glycation end-products (RAGE) on endothelial cells of the blood-brain barrier can bind OT and transport oxytocin from the blood into the brain, resulting in the regulation of brain OT levels as well as brain function and social behaviors.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、“母子の絆”や“愛情”の分子基盤の理解に繋がり、独自性と創造性に富む学術的にもユニークなものである。また、脳内に入りにくい薬剤を中枢神経系で作用させることができるドラッグデリバリー装置としての応用が可能である。さらに、自閉症スペクトラム障害を含む、統合失調症や反応性愛着障害などの精神疾患に対する新たな治療手段の開発を提供することにもなり得る。育児放棄、虐待などの今日の少子化時代において深刻化する社会問題の解決の一助になる可能性も秘めており、学術的意義に加え社会的意義も極めて高い。

Research Products

• [Int'l Joint Research] Harvard Medical School(米国)
• [Int'l Joint Research] クラスノヤルスク医科大学(ロシア連邦)
• [Int'l Joint Research] University of Saskatchewan(カナダ)
• [Int'l Joint Research] Krasnoyarsk State Medical University(ロシア連邦)
• [Int'l Joint Research] Harvard Medical School(米国)
• [Int'l Joint Research] Krasnoyarsk State Medical University(ロシア連邦)
• [Int'l Joint Research] University of Saskatchewan(カナダ)
• [Journal Article] RAGE signaling is required for AMPA receptor dysfunction in the hippocampus of hyperglycemic mice (2021)
  • Author(s): Momeni Zeinab、Bautista Maricris、Neapetung Joseph、Urban Rylan、Yamamoto Yasuhiko、Krishnan Anand、Campanucci Ver?nica A.
  • Journal Title: Physiology & Behavior Volume: 229 Pages: 113255-113255
  • DOI: 10.1016/j.physbeh.2020.113255
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH (2021)
  • Author(s): Takata Noboru、Ishii Kiyo-aki、Takayama Hiroaki、Nagashimada Mayumi、Kamoshita Kyoko、Tanaka Takeo、Kikuchi Akihiro、Takeshita Yumie、Matsumoto Yukako、Ota Tsuguhito、Yamamoto Yasuhiko、Yamagoe Satoshi、Seki Akihiro、Sakai Yoshio、Kaneko Shuichi、Takamura Toshinari
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 555-555
  • DOI: 10.1038/s41598-020-80689-0
  • Peer Reviewed / Open Access
• [Journal Article] Hyperglycemia induces RAGE-dependent hippocampal spatial memory impairments (2021)
  • Author(s): Momeni Zeinab、Neapetung Joseph、Pacholko Anthony、Kiir Tabitha Achan Bol、Yamamoto Yasuhiko、Bekar Lane K、Campanucci Ver?nica A.
  • Journal Title: Physiology & Behavior Volume: 229 Pages: 113287-113287
  • DOI: 10.1016/j.physbeh.2020.113287
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Aquaporin 1 elicits cell motility and coordinates vascular bed formation by downregulating thrombospondin type-1 domain-containing 7A in glioblastoma (2020)
  • Author(s): Oishi M, Munesue S, Harashima A, Nakada M, Yamamoto Y, Hayashi Y
  • Journal Title: Cancer Med Volume: 9 Issue: 11 Pages: 3904-3917
  • DOI: 10.1002/cam4.3032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neuroprotective effects of endogenous secretory receptor for advanced glycation end-products in brain ischemia (2020)
  • Author(s): Simizu Y, Harashima A, Munesue S, Oishi M, Hattori T, Hori O, Kitao Y, Yamamoto H, Leerach N, Nakada M, Yamamoto Y, Hayashi Y
  • Journal Title: Aging Dis Volume: 11 Issue: 3 Pages: 547-547
  • DOI: 10.14336/ad.2019.0715
  • Peer Reviewed / Open Access
• [Journal Article] Prophylactic Effect of Recombinant Human Soluble Thrombomodulin for Hepatic Sinusoidal Obstruction Syndrome Model Mice (2020)
  • Author(s): KANOU SHUNSUKE、MIYASHITA TOMOHARU、YAMAMOTO YASUHIKO、TAKADA SATOSHI、NAKURA MAKOTO、OKAZAKI MITSUYOSHI、OHBATAKE YOSHINAO、NAKANUMA SHINICHI、MAKINO ISAMU、TAJIMA HIDEHIRO、TAKAMURA HIROYUKI、FUSHIDA SACHIO、OHTA TETSUO
  • Journal Title: In Vivo Volume: 34 Issue: 3 Pages: 1037-1045
  • DOI: 10.21873/invivo.11873
  • Peer Reviewed
• [Journal Article] Intake of ω-6 Polyunsaturated Fatty Acid-Rich Vegetable Oils and Risk of Lifestyle Diseases (2020)
  • Author(s): Tetsumori Yamashima, Eishiro Mizukoshi, Hiroyuki Nakamura, Yasuhiko Yamamoto, Mitsuru Kikuchi, Tatsuya Yamashita, Shuichi Kaneko
  • Journal Title: Advances in Nutrition Volume: 11 Issue: 6 Pages: 1489-1509
  • DOI: 10.1093/advances/nmaa072
  • Peer Reviewed / Open Access
• [Journal Article] Effects of RAGE inhibition on the progression of the disease in hSOD1 G93A ALS mice (2020)
  • Author(s): Liu Liping、Killoy Kelby M.、Vargas Marcelo R.、Yamamoto Yasuhiko、Pehar Mariana
  • Journal Title: Pharmacology Research & Perspectives Volume: 8 Issue: 4
  • DOI: 10.1002/prp2.636
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Inhibitory Effects of Beraprost Sodium in Murine Hepatic Sinusoidal Obstruction Syndrome (2020)
  • Author(s): NAKURA MAKOTO、MIYASHITA TOMOHARU、YAMAMOTO YASUHIKO、TAKADA SATOSHI、KANOU SHUNSUKE、TAJIMA HIDEHIRO、TAKAMURA HIROYUKI、OHTA TETSUO
  • Journal Title: Anticancer Research Volume: 40 Issue: 9 Pages: 5171-5180
  • DOI: 10.21873/anticanres.14520
  • Peer Reviewed
• [Journal Article] Glycation reaction and the role of the receptor for advanced glycation end-products in immunity and social behavior (2020)
  • Author(s): Leerach Nontaphat、Harashima Ai、Munesue Seiichi、Kimura Kumi、Oshima Yu、Goto Hisanori、Yamamoto Hiroshi、Higashida Haruhiro、Yamamoto Yasuhiko
  • Journal Title: Glycoconjugate Journal Volume: in press Issue: 3 Pages: 303-310
  • DOI: 10.1007/s10719-020-09956-6
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Oxytocin and CD38 in the paraventricular nucleus play a critical role in paternal aggression in mice (2020)
  • Author(s): Shabalova Anna A.、Liang Mingkun、Zhong Jing、Huang Zhiqi、Tsuji Chiharu、Shnayder Natalia A.、Lopatina Olga、Salmina Alla B.、Okamoto Hiroshi、Yamamoto Yasuhiko、Zhong Zeng-Guo、Yokoyama Shigeru、Higashida Haruhiro
  • Journal Title: Hormones and Behavior Volume: 120 Pages: 104695-104695
  • DOI: 10.1016/j.yhbeh.2020.104695
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Distinct physical condition and social behavior phenotypes of CD157 and CD38 knockout mice during aging (2020)
  • Author(s): Gerasimenko Maria、Lopatina Olga、Shabalova Anna A.、Cherepanov Stanislav M.、Salmina Alla B.、Yokoyama Shigeru、Goto Hisanori、Okamoto Hiroshi、Yamamoto Yasuhiko、Ishihara Katsuhiko、Higashida Haruhiro
  • Journal Title: PLOS ONE Volume: 15 Issue: 12 Pages: e0244022-e0244022
  • DOI: 10.1371/journal.pone.0244022
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] RAGE regulates oxytocin transport into the brain (2020)
  • Author(s): Yamamoto Yasuhiko、Higashida Haruhiro
  • Journal Title: Communications Biology Volume: 3 Issue: 1 Pages: 70-70
  • DOI: 10.1038/s42003-020-0799-2
  • Peer Reviewed / Open Access
• [Journal Article] Protective role of endogenous secretory RAGE against contact hypersensitivity in mouse ear skin. (2019)
  • Author(s): Sagara A, Harashima A, Munesue S, Kimura K, Leerach N, Oshima Y, Kinoshita Y, Sakai N, Kaneko S, Wada T, Tsuneyama K, Yamamoto H, Yamamoto Y
  • Journal Title: Glycative Stress Research Volume: 6 Issue: 4 Pages: 270-277
  • DOI: 10.24659/gsr.6.4_270
  • NAID: 40022229100
  • ISSN: 2188-3602, 2188-3610
  • Peer Reviewed / Open Access
• [Journal Article] Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia (2019)
  • Author(s): Hosokawa K, Mizumaki H, Elbadry M, Saito C, Espinoza JL, An DTT, Katagiri T, Harashima A, Kikuchi A, Kanai A, Matsui H, Inaba T, Taniwaki M, Yamamoto Y, Nakao S
  • Journal Title: Leukemia Volume: 33 Issue: 11 Pages: 2732-2766
  • DOI: 10.1038/s41375-019-0510-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Deletion of CD38 Suppresses Glial Activation and Neuroinflammation in a Mouse Model of Demyelination (2019)
  • Author(s): Roboon Jureepon、Hattori Tsuyoshi、Ishii Hiroshi、Takarada-Iemata Mika、Le Thuong Manh、Shiraishi Yoshitake、Ozaki Noriyuki、Yamamoto Yasuhiko、Sugawara Akira、Okamoto Hiroshi、Higashida Haruhiro、Kitao Yasuko、Hori Osamu
  • Journal Title: Frontiers in Cellular Neuroscience Volume: 13 Pages: 258-258
  • DOI: 10.3389/fncel.2019.00258
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Monitoring of Heat Shock Response and Phenotypic Changes in Hepatocellular Carcinoma After Heat Treatment (2019)
  • Author(s): Zaimoku R, Miyashita T, Tajima H, Takamura H, Harashima A, Munesue S, Yamamoto Y, Ninomiya I, Fushida S, Harada K
  • Journal Title: Anticancer Research Volume: 39 Issue: 10 Pages: 5393-5401
  • DOI: 10.21873/anticanres.13733
  • Peer Reviewed
• [Journal Article] CD38, CD157, and RAGE as Molecular Determinants for Social Behavior. (2019)
  • Author(s): .Higashida H, Hashii M, Tanaka Y, Matsukawa S, Higuchi Y, Gabata R, Tsubomoto M, Seishima N, Teramachi M, Kamijima T, Hattori T, Hori O, Tsuji C, Cherepanov SM, Shabalova AA, Gerasimenko M, Minami K, Yokoyama S, Munesue SI, Harashima A, Yamamoto Y, Salmina AB, Lopatina O.
  • Journal Title: Cells. Volume: 9(1) Issue: 1 Pages: 62-62
  • DOI: 10.3390/cells9010062
  • NAID: 120006859506
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Tuning inflammation: inducing ectodomain shedding of receptor for advanced glycation end-products (RAGE) and formation of soluble RAGE (2019)
  • Author(s): Kawano S, Yamamoto Y
  • Journal Title: IMARS Highlights Volume: 14(1) Pages: 18-19
• [Journal Article] Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice. (2019)
  • Author(s): Yamamoto Y, Liang M, Munesue S, Deguchi K, Harashima A, Furuhara K, Yuhi T, Zhong J, Akther S, Goto H, Eguchi Y, Kitao Y, Hori O, Shiraishi Y, Ozaki N, Shimizu Y, Kamide T, Yoshikawa A, Hayashi Y, Nakada M, Lopatina O, Gerasimenko M, Komleva Y, Malinovskaya N, Salmina AB, Asano M, Nishimori K, Higashida H et al.,
  • Journal Title: Commun Biol Volume: ２ Issue: 1 Pages: 76-76
  • DOI: 10.1038/s42003-019-0325-6
  • NAID: 120006605138
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Citrullinated histone H3: early biomarker of neutrophil extracellular traps in septic liver damage (2019)
  • Author(s): Nomura K, Miyashita T, Yamamoto Y, Munesue S, Harashima A, Takayama H, Fushida S, Ohta T
  • Journal Title: J Surg Res Volume: 234 Pages: 132-138
  • DOI: 10.1016/j.jss.2018.08.014
  • Peer Reviewed
• [Journal Article] Development of a Highly Potent Analogue and a Long-Acting Analogue of Oxytocin for the Treatment of Social Impairment-Like Behaviors (2019)
  • Author(s): Ichinose W, Cherepanov SM, Shabalova AA, Yokoyama S, Yuhi T, Yamaguchi H, Watanabe A, Yamamoto Y, Okamoto H, Horike S, Terakawa J, Daikoku T, Watanabe M, Mano N, Higashida H, Shuto S
  • Journal Title: J Med Chem Volume: - Issue: 7 Pages: 3297-3310
  • DOI: 10.1021/acs.jmedchem.8b01691
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Extracellular S100A11 plays a critical role in spread of the fibroblast population in pancreatic cancers (2019)
  • Author(s): Takamatsu H, Yamamoto K, Tomonobu N, Murata H, Inoue Y, Yamauchi A, Sumardika W, Youyi C, Kinoshita R, Yamamura M, Fujiwara H, Mitsui Y, Araki K, Futami J, Saito K, Iioka H, Ruma MW, Putranto EW, Nishibori M, Kondo E, Yamamoto Y, Toyooka S, Sakaguchi M
  • Journal Title: Oncol Res Volume: - Issue: 6 Pages: 713-727
  • DOI: 10.3727/096504018x15433161908259
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] RAGE-dependent potentiation of TRPV1 currents in sensory neurons exposed to high glucose (2018)
  • Author(s): Lam D, Theaker M, Momeni Z, Yamamoto Y, Jagadeeshan S, Campanucci VA
  • Journal Title: PLoS ONE Volume: 13(2) Issue: 2 Pages: e0193312-e0193312
  • DOI: 10.1371/journal.pone.0193312
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Anti-tumor effects of a nonsteroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression. (2018)
  • Author(s): Higuchi T, Takeuchi A, Munesue S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Inatani H, Shimozaki S, Kato T, Aoki Y, Abe K, Taniguchi Y, Aiba H, Murakami H, Harashima A, Yamamoto Y, Tsuchiya H.
  • Journal Title: Cancer Med. Volume: 印刷中 Issue: 5 Pages: 1944-1954
  • DOI: 10.1002/cam4.1438
  • NAID: 120006605139
  • Peer Reviewed / Open Access
• [Journal Article] CD38 in the nucleus accumbens is critical in paternal behavior in mice (2018)
  • Author(s): Akther S, Zhong J, Liang M, Cherepanov SM, Lopatina O, Salmina AB, Tsuji C, Tsuji T, Yamamoto Y, Yokoyama S, Higashida H
  • Journal Title: Messenger Volume: 6 Pages: 81-84
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] TRPM2, a new player, in cyclic ADP-ribose/CD38-dependent oxytocin release in the hypothalamus (2018)
  • Author(s): Tsuji T, Liang M, Lopatina O, Yuhi T, Tsuji C, Zhong J, Akther S, Zhong J, Nishimura T, Amina S, Liu HX, Hashii M, Furuhara K, Yamamoto Y, Yokoyama S, Higashida H
  • Journal Title: Messenger Volume: 6 Pages: 71-75
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nitration and glycation turn mature NGF into a toxic factor for motor neurons: a role for p75NTRand RAGE signaling in ALS (2018)
  • Author(s): Kim MJ, Vargas MR, Harlan BA, Killoy KM, Ball L, Comte-Walters S, Gooz M, Yamamoto Y, Beckman JS, Barbeito L, Pehar M
  • Journal Title: Antioxid Redox Signal Volume: 28(18) Issue: 18 Pages: 1587-1602
  • DOI: 10.1089/ars.2016.6966
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system (2018)
  • Author(s): El-Far Ali、Munesue Seiichi、Harashima Ai、Sato Akira、Shindo Mika、Nakajima Shingo、Inada Mana、Tanaka Mariko、Takeuchi Akihiko、Tsuchiya Hiroyuki、Yamamoto Hiroshi、Shaheen Hazem、El-Sayed Yasser、Kawano Shuhei、Tanuma Sei-Ichi、Yamamoto Yasuhiko
  • Journal Title: Oncology Letters Volume: 15 Pages: 4627-4634
  • DOI: 10.3892/ol.2018.7902
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Soluble thrombomodulin attenuates endothelial cell damage in hepatic sinusoidal obstruction syndrome (2018)
  • Author(s): Takada S, Miyashita T, Yamamoto Y, Kanou S, Munesue S, Ohbatake Y, Nakanuma S, Okamoto K, Sakai S, Knoshita J, Makino I, Nakamura K, Tajima H, Takamura H, Ninomiya I, Fushida S, Ohta T
  • Journal Title: In Vivo Volume: 32(6) Issue: 6 Pages: 1409-1417
  • DOI: 10.21873/invivo.11393
  • Peer Reviewed
• [Journal Article] JNK and ATF4 as two important platforms for tumor necrosis factor-α-stimulated shedding of receptor for advanced glycation endproducts (2018)
  • Author(s): Miyoshi A, Koyama S, Sasagawa-Monden M, Kadoya M, Konishi K, Shoji T, Inaba M, Yamamoto Y, Koyama H
  • Journal Title: FASEB J Volume: 33(3) Issue: 3 Pages: 3575-3589
  • DOI: 10.1096/fj.201701553rr
  • Peer Reviewed
• [Presentation] Pattern-recognition receptor RAGE is a transporter of oxytocin, a chemical messenger that affects social behaviors (2020)
  • Author(s): 山本靖彦
  • Organizer: Commemoration for Foundation of KU Russian Alumni Association and Japan-Russia Joint Symposium 2020
  • Int'l Joint Research
• [Presentation] 臨床医が知っておくべき糖尿病の基礎１「糖尿病合併症とRAGE」 (2020)
  • Author(s): 山本靖彦
  • Organizer: 第54回糖尿病学の進歩
  • Invited
• [Presentation] Glycation reaction and physiological roles of the receptor for glycated proteins (2019)
  • Author(s): Yasuhiko Yamamoto
  • Organizer: International Symposium on Glycoconjugates (Glyco25 Symposium)
  • Int'l Joint Research / Invited
• [Presentation] Pathological and physiological roles of a pattern-recognition receptor RAGE (2019)
  • Author(s): Yamamoto Y, Munesue S, Harashima A, Kimura K, Leerach N, Oshima Y, Kinoshita Y
  • Organizer: 9th International DAMPs and Alarmins Symposium (9th iDEAs)
  • Int'l Joint Research
• [Presentation] Differential roles of RAGE species for renal tubular damages (2019)
  • Author(s): Miyagawa T, Iwata Y, Ogura H, Sato K, Kitajima S, Toyama T, Hara A, Sakai N, Shimizu M, Furuichi K, Yamamoto Y, Wada T
  • Organizer: ASN 2019
  • Int'l Joint Research
• [Presentation] Glycation reaction in diabetes (2019)
  • Author(s): Yasuhiko Yamamoto
  • Organizer: 2019年日本分子生物学会
  • Invited
• [Presentation] 糖尿病合併症の成因 (2019)
  • Author(s): 山本靖彦
  • Organizer: 第62回日本糖尿病学会
  • Invited
• [Presentation] 生体内で生じるグリケーションと病態 (2019)
  • Author(s): 山本靖彦
  • Organizer: 第92回日本生化学会大会
  • Invited
• [Presentation] 糖尿病合併症の成因 (2019)
  • Author(s): 山本靖彦
  • Organizer: 第34回日本糖尿病合併症学会
  • Invited
• [Presentation] 糖化研究からみえてきた愛情のサイエンス ～AGEs受容体の生理的役割～ (2019)
  • Author(s): 山本靖彦
  • Organizer: 第19回日本抗加齢医学会総会
  • Invited
• [Presentation] 糖化研究は老化をこえて愛情のサイエンスにまで展開している (2019)
  • Author(s): 山本靖彦
  • Organizer: 第29回臨床内分泌代謝Update
  • Invited
• [Presentation] Analysis of paternal aggression in CD38 knockout autism model mice (2019)
  • Author(s): Shabalova AA, Liang M, Zhong J, Tsuji C, Yamamoto Y, Yokoyama S, Higashida H
  • Organizer: International Symposium on Chronic Disease and Glycation Biology
  • Int'l Joint Research
• [Presentation] Development of remarkably strong and long-active oxytocin analogues for treatment of social impairment-like behavior (2019)
  • Author(s): Cherepanov SM, Wataru I, Yuhi T, Shabalova AA, Yokoyama S, Yamamoto Y, Higashida H
  • Organizer: International Symposium on Chronic Disease and Glycation Biology
  • Int'l Joint Research
• [Presentation] Maternal behavior of CD38 KO autism model mouse dam is improved by social support (2019)
  • Author(s): Tsuji T, Yokoyama S, Yamamoto Y, Higashida H, Tsuji C
  • Organizer: International Symposium on Chronic Disease and Glycation Biology
  • Int'l Joint Research
• [Presentation] RAGE-dependent leukocyte accumulation is critical pathology of cerebral vasospasm/neuronal dysfunction after subarachnoid haemorrhage (2019)
  • Author(s): Ishii H, Aida Y, Seiichi M, Hattori T, Takarada-Iemata M, Kitao Y, Nakada M, Yasuhiko Y, Hori O
  • Organizer: International Symposium on Chronic Disease and Glycation Biology
  • Int'l Joint Research
• [Presentation] Drug library screening to identify new compounds for inducing ectodomain shedding of RAGE and formation of soluble RAGE (2019)
  • Author(s): Kawano S, Miyazawa H, Munesue S, Harashima A, Tanaka M, Thoa DTM, Leerach N, Ooshima Y, Kinoshita Y, Yamamoto H, Yamamoto Y
  • Organizer: International Symposium on Chronic Disease and Glycation Biology
  • Int'l Joint Research
• [Presentation] Effects of salicylate and pyridoxamine on diabetic nephropathy (2019)
  • Author(s): Munesue S, Abouzed TK, Harashima A, Yamamoto H, Yamamoto Y
  • Organizer: International Symposium on Chronic Disease and Glycation Biology
  • Int'l Joint Research
• [Presentation] In vitro effects of a novel RAGE inhibitor on tumor malignancy in human fibrosarcoma HT1080 cells (2019)
  • Author(s): Oshima Y, Munesue S, El-Far AM, Harashima A, Takeuchi A, Tanaka M, Kawano S, Sato S, Shindo M, Nakajima S, Inada A, Tanuma S, Yamamoto H, Yamamoto Y
  • Organizer: International Symposium on Chronic Disease and Glycation Biology
  • Int'l Joint Research
• [Presentation] Beneficial effects of zaltprofen on anti-obesity/diabetes via activation of PPARγ (2019)
  • Author(s): Kimura K, Furukawa A, Watanebe K, Munesue S, Harashima A, Leerach N, Oshima Y, Tanaka M, Kawano S, Kinoshita Y, Nagashimada M, Higuchi T, Takeuchi A, Yamamoto Y
  • Organizer: International Symposium on Chronic Disease and Glycation Biology
  • Int'l Joint Research
• [Presentation] AQP1-elicited invasion and angiogenesis is mediated by thrombospondin type 1 domain containing 7A (THSD7A) in glioblastoma multiforme (2019)
  • Author(s): Oishi M, Yamamoto Y, Munesue S, Harashima S, Nakada M, Hayashi Y
  • Organizer: International Symposium on Chronic Disease and Glycation Biology
  • Int'l Joint Research
• [Presentation] 避けられない糖化反応とその生体応答系 (2018)
  • Author(s): 山本靖彦
  • Organizer: 日本生化学会東北地方会第84回例会
  • Invited
• [Presentation] グリケーション研究の潮流「グリケーションとその生体応答系」 (2018)
  • Author(s): 山本靖彦
  • Organizer: 第91回日本生化学会大会
  • Invited
• [Presentation] 糖尿病における血管病態の共通項を巡って「グリケーションとその除去酵素による糖尿病合併症」 (2018)
  • Author(s): 山本靖彦
  • Organizer: 第61回日本糖尿病学会
  • Invited
• [Presentation] 糖化生物学の病態生理「グリケーションとその生体応答系」 (2018)
  • Author(s): 山本靖彦
  • Organizer: 第41回日本分子生物学会大会
  • Invited
• [Presentation] 糖尿病合併症としての臓器障害～克服に向けて～「グリケーションと糖尿病の合併症」 (2018)
  • Author(s): 山本靖彦
  • Organizer: 第33回日本糖尿病合併症学会
  • Invited
• [Presentation] 栄養と糖尿病合併症 (2018)
  • Author(s): 山本靖彦
  • Organizer: 2018年度認定臨床栄養医金沢研修会
  • Invited
• [Presentation] Pattern-recognition receptor RAGE in health and disease (2018)
  • Author(s): 山本靖彦
  • Organizer: 第19回東京都医学総合研究所国際シンポジウム
  • Int'l Joint Research / Invited
• [Presentation] Pattern-recognition receptor RAGE: foe or friend? (2018)
  • Author(s): 山本靖彦
  • Organizer: RUSSIA-JAPAN Medical Symposium
  • Int'l Joint Research / Invited
• [Presentation] Pattern-recognition receptor RAGE: foe or friend for life? (2018)
  • Author(s): 山本靖彦
  • Organizer: 第13回国際メイラード反応シンポジウム（ISMR13）
  • Int'l Joint Research / Invited
• [Book] べインズ・ドミニチャク 生化学 (2018)
  • Author(s): 谷口直之、岩井一宏、藤井順逸、本家孝一監訳
  • Total Pages: 692
  • Publisher: エルゼビアジャパン
• [Remarks] 金沢大学医薬保健研究域医学系血管分子生物学HP
  • URL: https://biochem2.w3.kanazawa-u.ac.jp/
• [Remarks] 金沢大学医薬保健研究域医学系血管分子生物学ホームページ
  • URL: https://biochem2.w3.kanazawa-u.ac.jp/
• [Remarks] 金沢大学医薬保健研究域医学系血管分子生物学ホームページ
  • URL: http://biochem2.w3.kanazawa-u.ac.jp/