Cellular and molecular analysis of skeletal muscle protection by female sex hormones
| Project/Area Number |
18K06897
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 48030:Pharmacology-related
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
黒川 洵子 静岡県立大学, 薬学部, 教授 (40396982)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 感染症 / 骨格筋 / 性差 / 性ホルモン / ICU-AW / PICS / サイトカイン / 炎症 / 敗血症 / 炎症性サイトカイン / カヘキシー / サルコペニア / リポ多糖 / セルモーションイメージング |
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| Outline of Final Research Achievements |
Muscle weakness and atrophy are typical pathophysiological conditions in the complication of infectious diseases. Based on the sex differences in infectious disease symptoms and mortality, this study examined the effects of sex hormones on septic muscle weakness and atrophy. In cultured skeletal myotubes, testosterone and progesterone showed no efficacy against endotoxin (LPS)-induced muscle atrophy, while estradiol significantly inhibited muscle atrophy. Estradiol also inhibited sepsis-induced muscle weakness in ovariectomized mice. Estradiol did not act on LPS-induced proteolytic system activation in cultured skeletal myoblasts, but significantly suppressed the inflammatory response, which is responsible for its muscle-preserving effect. The results of this study are significant for the treatment of post-infectious disease complications.
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| Academic Significance and Societal Importance of the Research Achievements |
新型コロナウィルス感染症蔓延により、長期間つづく後遺症(long COVID)が社会問題化してきた。全身のだるさ・脱力と表現される運動機能障害はその典型例である。研究チームはこれまでに感染症により引き起こされる全身炎症と骨格筋障害の研究を進めてきた。一般的に感染症症状は、女性において男性より軽度である。我々は女性ホルモンであるエストラジオールが病原体成分による骨格筋培養細胞の細胞萎縮および敗血症モデルマウスの筋力低下を抑制することをはじめて見出した。本研究結果はエストラジオールとその誘導体が感染症後遺症の治療薬として有望であることを示す。
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Report
(5 results)
Research Products
(53 results)
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[Journal Article] Systematic Expression Analysis of Genes Related to Generation of Action Potentials in Human iPS Cell-Derived Cardiomyocytes2019
Author(s)
Masami Kodama, Kazuharu Furutani, Reiko Kimura, Tomoko Ando, Kazuho Sakamoto, Shushi Nagamori, Takashi Ashihara, Yoshihisa Kurachi, Yuko Sekino, Tetsushi Furukawa, Yasunari Kanda, Junko Kurokawa
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Journal Title
Journal of Pharmacological Sciences
Volume: 140
Issue: 4
Pages: 325-330
DOI
Related Report
Peer Reviewed / Open Access
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