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Development of cancer metastasis suppression therapy focusing on the renin-angiotensin system

Research Project

Project/Area Number 18K06907
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 48030:Pharmacology-related
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

Ishikane Shin  産業医科大学, 医学部, 講師 (40470190)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsアンギオテンシンII / 癌転移 / 悪性黒色腫 / 乳がん / 転移抑制薬 / アンギオテンII / アンジオテンシンII / 血管内皮細胞 / 血行性癌転移 / 高血圧 / レニン・アンジオテンシン系
Outline of Final Research Achievements

In this study, we sought to elucidate the mechanisms by which angiotensin II (Ang II) exacerbates hematogenous metastasis in mouse tumor cells. Ang II exacerbates hematogenous metastasis of melanoma cells by promoting adhesion molecules-mediated adhesion of cancer cells to vascular endothelial cells. Ang II affected the fibroblasts around cancer cells to accelerate the tumor growth and facilitate metastasis formation and suggests the possibility that Ang II modifies tumor microenvironment.

Academic Significance and Societal Importance of the Research Achievements

本邦の高血圧患者は、厚生労働省による平成26年度調査報告では約1100万人とされ、今後も患者数の増加が予測される。癌患者における最も多い併発症は高血圧症であることからも、本研究による癌転移抑制療法の適応範囲は広く、高額負担なく、安全な治療法を行うことができることは医療費削減の観点からも非常に有益である。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (18 results)

All 2021 2020 2019 2018

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (14 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Differentiation-inducing factor-1 potentiates adipogenic differentiation and attenuates the osteogenic differentiation of bone marrow-derived mesenchymal stem cells2021

    • Author(s)
      Ishikane Shin、Ikushima Eigo、Igawa Kazunobu、Tomooka Katsuhiko、Takahashi-Yanaga Fumi
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

      Volume: 1868 Issue: 2 Pages: 118909-118909

    • DOI

      10.1016/j.bbamcr.2020.118909

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a novel and rapid measurement system for growth differentiation factor-15, progranulin, and osteopontin in uterine sarcoma2020

    • Author(s)
      Maeno Mitsuo、Mizutani Tetsuya、Tsuyoshi Hideaki、Yamada Shizuka、Ishikane Shin、Kawabe Shinya、Nishimura Kengo、Yamada Masami、Miyamoto Kaoru、Yoshida Yoshio
    • Journal Title

      Endocrine Journal

      Volume: 67 Issue: 1 Pages: 91-94

    • DOI

      10.1507/endocrj.EJ18-0572

    • NAID

      130007790959

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation.2019

    • Author(s)
      Morishige S, Takahashi-Yanaga F, Ishikane S, Arioka M, Igawa K, Kuroo A, Tomooka K, Shiose A, Sasaguri T.
    • Journal Title

      Biochemical Pharmacology

      Volume: 168 Pages: 82-90

    • DOI

      10.1016/j.bcp.2019.06.018

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II promotes pulmonary metastasis of melanoma through the activation of adhesion molecules in vascular endothelial cells2018

    • Author(s)
      Ishikane S, Hosoda H, Nojiri T, Tokudome T, Mizutani T, Miura K, Akitake Y, Kimura T, Imamichi Y, Kawabe S, Toyohira Y, Yanagihara N, Takahashi-Yanaga F, Miyazato M, Miyamoto K, Kangawa K
    • Journal Title

      Biochemical Pharmacology

      Volume: 154 Pages: 136-147

    • DOI

      10.1016/j.bcp.2018.04.012

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Angiotensin II promotes tumor growth and metastatic lesion formation of murine TNBC 4T1 cells through the fibroblasts around cancer cells2021

    • Author(s)
      瀧口 知浩, 高橋 富美, 石兼 真, 笹栗 俊之
    • Organizer
      第94回日本薬理学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 2,5-Dimethylcelecoxib attenuates cardiac remodeling after cryoinjury-induced myocardial infarction by suppressing the fibroblast-myofibroblast transformation2021

    • Author(s)
      幾島栄悟, 石兼 真, 岸上 赳大, 松永 洋明, 瀧口 知浩, 豊平 由美子, 高橋 富美
    • Organizer
      第94回日本薬理学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Differentiation-inducing factor-1 accelerates adipogenic differentiation and suppresses the osteogenic differentiation of bone marrow-derived mesenchymal stem cells2021

    • Author(s)
      石兼 真, 幾島 栄悟, 瀧口 知浩, 松永 洋明, 岸上 赳大, 豊平 由美子, 高橋 富美
    • Organizer
      第94回日本薬理学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 心筋梗塞後心臓リモデリングにおける筋線維芽細胞形質転換に対する ジメチルセレコキシブの作用の検討2021

    • Author(s)
      幾島栄悟,石兼真,岸上赳大,松永洋明,瀧口知浩,豊平由美子,高橋 富美
    • Organizer
      第73回日本薬理学会西南部会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Differentiation-inducing factor-1による骨髄由来間葉系幹細胞の脂 肪細胞分化促進・骨芽細胞分化抑制作用2021

    • Author(s)
      石兼真,幾島栄悟,瀧口知浩,松永洋明,岸上赳大,豊平由美子,高橋 富美
    • Organizer
      第73回日本薬理学会西南部会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Differentiation-including factor-1は骨髄由来間葉系幹細胞の脂肪細胞分化を促進し、骨芽細胞文化を抑制する2021

    • Author(s)
      石兼真, 幾島栄悟, 瀧口知浩, 豊平由美子, 高橋富美
    • Organizer
      第38回産業医科大学学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] アンギオテンシンⅡは癌周囲環境を変化させることによりトリプルネガティブ乳癌4T1細胞の増殖と転移を促進する2019

    • Author(s)
      瀧口 知浩, 高橋 富美, 石兼 真, 笹栗 俊之
    • Organizer
      第93回日本薬理学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] AngiotensinⅡは癌周囲環境を変化させ、乳癌自然肺転移を促進する2019

    • Author(s)
      瀧口知浩, 高橋富美, 石兼真, 笹栗俊之
    • Organizer
      第72回日本薬理学会西南部会
    • Related Report
      2019 Research-status Report
  • [Presentation] Differentiation-inducing factor-1 accelerates bone marrow-derived mesenchymal stem cells differentiation into adipocyte2019

    • Author(s)
      石兼 真, 幾島 栄悟, 瀧口 知浩, 豊平 由美子, 高橋 富美
    • Organizer
      第93回日本薬理学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 2,5-Dimethylcelecoxib attenuates cardiac fibrosis after cryoinjury-induced myocardial infarction by suppressing the fibroblast-myofibroblast differentiation2019

    • Author(s)
      幾島 栄悟, 石兼 真, 瀧口 知浩, 豊平 由美子, 高橋 富美
    • Organizer
      第93回日本薬理学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 骨髄由来間葉系幹細胞に対するdifferentiation-inducing factor-1による分化誘導調節機序の解明2019

    • Author(s)
      石兼真, 幾島栄悟, 瀧口知浩, 豊平由美子, 高橋富美
    • Organizer
      第72回日本薬理学会西南部会
    • Related Report
      2019 Research-status Report
  • [Presentation] Glycogen synthase kinase-3 調整薬による間葉系幹細胞の分化制御機序の解明2019

    • Author(s)
      石兼真, 豊平由美子, 高橋富美
    • Organizer
      第37回産業医科大学学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Angiotensin II increase the pulmonary metastasis through the vascular endothelial cell adhenent pathway in hematogenous metastasis of melanoma cells.2018

    • Author(s)
      Shin Ishikane, Hiroshi Hosoda, Takashi Nojiri, Takeshi Tokudome, Tetsuya Mizutani, Yumiko Toyohira, Mikiya Miyazato, Kaoru Miyamoto, Kenji Kangawa, Fumi Takahashi-Yanaga.
    • Organizer
      WCP2018- 18th WORLD CONGRESS OF BASIC AND CLINICAL PHARMACOLOGY
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Angiotensin II promotes hematogenous cancer metastasis through the activation of vascular endothelial adhesion molecules.2018

    • Author(s)
      Shin Ishikane, Fumi Takahashi-Yanaga.
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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