Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Outline of Final Research Achievements |
Gcn1 is ribosome binding protein which mediates translational attenuation and amino acid synthesis in response to amino acid starvation. Since Gcn1 knockout mice show embryonic growth retardation and lethality, current study analyzed the phenotype of conditional Gcn1 knockout (CKO) mice employing tamoxifen-inducible Cre and Gcn1 flox mice. Gcn1 CKO mice generated by tamoxifen administration showed decrease in the body weight and accompanying decreases in blood glucose, liver weight and lipid content, and white adipose tissue weight. These data implicates Gcn1 is involved in resistance to tamoxifen toxicity and metabolic homeostasis.
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