Analysis of temporal and spatial dynamics of interaction between tumor-associated glycosphingolipids and membrane molecules, and mechanisms for enhancement of tumor phenotypes

• Project/Area Number: 18K06925
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 48040:Medical biochemistry-related
• Research Institution: Chubu University
• Principal Investigator: Furukawa Keiko 中部大学, 生命健康科学部, 教授 (50260732)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: スフィンゴ糖脂質 / 癌関連糖鎖 / エクソソーム / 膜分子 / タイムラプス観察 / 糖鎖リモデリング細胞 / タイムラプス / リーディングエッジ / がん細胞膜 / 細胞動態 / 脂質ラフト

Outline of Final Research Achievements

In this study, we analyzed substantial properties and functions of cancer-associated acidic glycosphingolipids (GD3 and GD2) in cancer cells and exosomes. Comparative analysis using glyco-remodeling cells with various acidic glycolipid expression revealed that cell proliferation and adhesion were enhanced in GD3/GD2-expressing cells. Time-laps observation of cells into which fluorescence-labeled GD3 was incorporated showed assembly of GD3 at the leading edge, suggesting that GD3 leads direction of the cell migration. Analyses of exosomes revealed that amounts of CD63, TSG101 and Alix increased in GD3 and/or GD2-containing exosomes, indicating their important roles in the generation and biological activity of exosomes.

Academic Significance and Societal Importance of the Research Achievements

私達はこれまでに、癌関連酸性糖脂質のGD3およびGD2が癌性形質やシグナル伝達の増強に関与することを報告してきた。
本研究では、リーディングエッジにGD3が集合し、GD3が細胞の移動方向を先導する可能性を示した。また、エクソソームについては、GD3またはGD2を有するエクソソームにおいて、エクソソームのマーカー分子であるCD63, TSG101, 及びAlix の含有増大が認められた。よって、細胞動態や細胞外分泌小胞においても、癌関連酸性糖脂質が重要な役割を果たす可能性が示され、学術的に有意義である。

Research Products

• [Journal Article] Lack of GD3 synthase (St8sia1) attenuates malignant properties of gliomas in genetically engineered mouse model. (2021)
  • Author(s): Ohkawa, Y., Zhang, P., Momota, H., Kato, A., Hashimoto, N., Ohmi, Y., Bhuiyan, R.H., Natsume, A., Wakabayashi, T., Furukawa, K, Furukawa K.
  • Journal Title: Cancer Sci. Volume: 112 Issue: 9 Pages: 3756-3768
  • DOI: 10.1111/cas.15032
  • Peer Reviewed / Open Access
• [Journal Article] St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity (2021)
  • Author(s): Zhang, P., Ohkawa, Y., Yamamoto, S., Momota, H., Kato, A., Kaneko, K., Natsume, A., Farhana, Y., Ohmi, Y., Okajima, T., Bhuiyan, R.H., Wakabayashi, T., Furukawa, K., Furukawa, K.
  • Journal Title: Nagoya Journal of Medical Science Volume: 83 Issue: 3 Pages: 535-549
  • DOI: 10.18999/nagjms.83.3.535
  • NAID: 120007147350
  • ISSN: 0027-7622
  • URL: https://nagoya.repo.nii.ac.jp/records/2001444
  • Peer Reviewed / Open Access
• [Journal Article] Ganglioside GD2 Enhances the Malignant Phenotypes of Melanoma Cells by Cooperating with Integrins. (2021)
  • Author(s): Yesmin, F., Bhuiyan, R.H., Ohmi, Y., Yamamoto, S., Kaneko, K., Ohkawa, Y., Zhang, P., Hamamura, K., Cheung, N-K.V., Kotani, N., Honke, K., Okajima, T., Kambe, M., Tajima, O., Furukawa, K., Furukawa, K.
  • Journal Title: Int. J. Mol. Sci. Volume: 23 Issue: 1 Pages: 423-442
  • DOI: 10.3390/ijms23010423
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lewis y Expressed in Oral Squamous Cell Carcinoma Attenuates Malignant Properties via Down-regulation of EGF Signaling (2021)
  • Author(s): Hotta H, Hamamura K, Shibuya H, Ohmi Y, Furukawa K, Furukawa K
  • Journal Title: Anticancer Res. Volume: 41 Issue: 4 Pages: 1821-1830
  • DOI: 10.21873/anticanres.14948
  • Peer Reviewed / Open Access
• [Journal Article] St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity. (2021)
  • Author(s): Zhang P, Ohkawa Y, Yamamoto S, Momota H, Kato A, Kaneko K, Natsume A, Farhana Y, Ohmi Y, Okajima T, Bhuiyan R.H., Wakabayashi T, Furukawa K, Furukawa K
  • Journal Title: Nagoya J. Med. Sci. in press 2021 Volume: -
  • NAID: 120007147350
  • Peer Reviewed
• [Journal Article] Elucidation of Pathological Mechanisms for Involvement of Gangliosides in Intractable Diseases (2020)
  • Author(s): Y Ohmi, K Furukawa, K Furukawa
  • Journal Title: Trends in Glycoscience and Glycotechnology Volume: 32 Issue: 187 Pages: E81-E86
  • DOI: 10.4052/tigg.2011.2E
  • NAID: 130007846166
  • ISSN: 0915-7352, 1883-2113
  • Year and Date: 2020-05-25
  • Peer Reviewed / Open Access
• [Journal Article] Majority of alpha2,6-sialylated glycans in adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes (2020)
  • Author(s): Ohmi Y, Nishikaze T, Kitaura Y, Ito T, Yamamoto S, Sugiyama F, Matsuyama M, Takahashi Y, Takeda A, Kawahara T, Okajima T, Furukawa K, Furukawa K
  • Journal Title: Glycobiology Volume: 105 Issue: 5 Pages: 1-14
  • DOI: 10.1093/glycob/cwaa105
  • Peer Reviewed / Open Access
• [Journal Article] Aminoglycosides are efficient reagents to induce readthrough of premature termination codon in mutant B4GALNT1 genes found in families of hereditary spastic paraplegia (2020)
  • Author(s): Yesmin F, Bhuiyan RH, Ohmi Y, Ohkawa Y, Tajima O, Okajima T, Furukawa K, Furukawa K.
  • Journal Title: J Biochem. Volume: 168 Issue: 2 Pages: 103-112
  • DOI: 10.1093/jb/mvaa041
  • NAID: 40022308727
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Novel molecular mechanisms for roles of gangliosides in the nervous system elucidated by genetic engineering. (2020)
  • Author(s): Furukawa, K., Ohmi, Y., Yesmin, F., Tajima, O., Kondo, Y., Pu Zhang, P., Hashimoto, N., Ohkawa, Y., Bhuiyan, R.H., Furukawa, K.
  • Journal Title: Int. J. Mol. Sci. Volume: 21 Issue: 6 Pages: 1906-1906
  • DOI: 10.3390/ijms21061906
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Elucidation of the enigma of glycosphingolipids in the regulation of inflammation and degeneration — Great progress over the last 70 years — (2019)
  • Author(s): Koichi Furukawa, Yuhsuke Ohmi, Yuji Kondo, Robiul H. Bhuiyan, Orie Tajima, Yuki Ohkawa, Keiko Furukawa
  • Journal Title: Proceedings of the Japan Academy, Series B Volume: 95 Issue: 3 Pages: 136-149
  • DOI: 10.2183/pjab.95.011
  • NAID: 130007608536
  • ISSN: 0386-2208, 1349-2896
  • Year and Date: 2019-03-11
  • Peer Reviewed / Open Access
• [Journal Article] TNFα-signal and cAMP-mediated signals oppositely regulate melanoma- associated ganglioside GD3 synthase gene in human melanocytes. (2019)
  • Author(s): Takeuchi R, Kambe M, Miyata M, Jeyadevan U, Tajima O, Furukawa K, Furukawa K.
  • Journal Title: Sci Rep. Volume: 9 Issue: 1 Pages: 14740-14740
  • DOI: 10.1038/s41598-019-51333-3
  • Peer Reviewed / Open Access
• [Journal Article] The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface. (2019)
  • Author(s): Hashimoto N, Ito S, Tsuchida A, Bhuiyan RH, Okajima T, Yamamoto A, Furukawa K, Ohmi Y, Furukawa K.
  • Journal Title: J Biol Chem. Volume: 294 Issue: 28 Pages: 10833-10845
  • DOI: 10.1074/jbc.ra118.007083
  • NAID: 120007168785
  • Peer Reviewed / Open Access
• [Journal Article] New era of research on cancer‐associated glycosphingolipids. (2019)
  • Author(s): Koichi Furukawa, Yuhsuke Ohmi, Yuki Ohkawa, Robiul H. Bhuiyan, Pu Zhang, Orie Tajima, Noboru Hashimoto, Kazunori Hamamura, Keiko Furukawa.
  • Journal Title: Cancer Science Volume: - Issue: 5 Pages: 1-8
  • DOI: 10.1111/cas.14005
  • Peer Reviewed / Open Access
• [Journal Article] Anti-GD2 CAR T cells could prove transformative for H3-K27M+ diffuse midline gliomas (2018)
  • Author(s): Koichi Furukawa, Yuhsuke Ohmi, Keiko Furukawa
  • Journal Title: Translational Cancer Research Volume: 8(2) Issue: S2 Pages: 87-93
  • DOI: 10.21037/tcr.2018.08.21
  • Peer Reviewed / Open Access
• [Journal Article] Loss of enzyme activity of mutated B4GALNT1 gene products found in patients with hereditary spastic paraplegia induces relatively mild neurological disorders: Similarity with phenotypes of B4galnt1 knockout mice. (2018)
  • Author(s): Robiul H. Bhuiyan, Yuhsuke Ohmi, Yuki Ohkawa, Pu Zhang, Maiko Takano, Noboru Hashimoto, Tetsuya Okajima, Keiko Furukawa, Koichi Furukawa
  • Journal Title: Neuroscience Volume: 397 Pages: 94-106
  • DOI: 10.1016/j.neuroscience.2018.11.034
  • Peer Reviewed
• [Journal Article] Differential roles of gangliosides in malignant properties of melanomas. (2018)
  • Author(s): Ohmi Y, Kambe M, Ohkawa Y, Hamamura K, Tajima O, Takeuchi R, Furukawa K, Furukawa K.
  • Journal Title: PLoS One Volume: 13 Pages: 1-23
  • Peer Reviewed / Open Access
• [Journal Article] Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells. (2018)
  • Author(s): Tsuchida A, Senda M, Ito A, Saito S, Kiso M, Ando T, Harduin-Lepers A, Matsuda A, Furukawa K, Furukawa K.
  • Journal Title: Sci Rep. Volume: 8 Issue: 1 Pages: 1-15
  • DOI: 10.1038/s41598-018-25521-6
  • NAID: 120006941172
  • Peer Reviewed / Open Access
• [Journal Article] Lactosylceramide synthase, encoded by β4-galactosylteransferase-5 and -6, is pivotal for neuronal generation and myelin formation in mice. (2018)
  • Author(s): Yoshihara T, Satake H, Nishie T, Okino N, Hatta T, Otani H, Suzuki H, Sugihara K, Kamimura E, Tokuda N, Furukawa K, Furukawa K, Ito M, Asano M.
  • Journal Title: Plos Genetics Volume: 14 Issue: 8 Pages: 1-24
  • DOI: 10.1371/journal.pgen.1007545
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide CRISPR screens for Shiga toxins and Ricin reveal Golgi proteins critical for glycosylation. (2018)
  • Author(s): Songhai Tian, Khaja Muneeruddin, Mei Yuk Choi, Liang Tao, Robiul H. Bhuiyan, Yuhsuke Ohmi, Keiko Furukawa, Koichi Furukawa, Sebastian Boland, Scott A. Shaffer, Rosalyn M. Adams, Min Dong
  • Journal Title: PLoS Biol. Volume: 16(11) Issue: 11 Pages: 1-31
  • DOI: 10.1371/journal.pbio.2006951
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gangliosides in Inflammation and Neurodegeneration. (2018)
  • Author(s): Furukawa K, Ohmi Y, Tajima O, Ohkawa Y, Kondo Y, Shuting J, Hashimoto N, Furukawa K.
  • Journal Title: Prog Mol Biol Transl Sci. Volume: 156 Pages: 265-287
  • Peer Reviewed
• [Journal Article] Enhancement of malignant properties of human glioma cells by ganglioside GD3/GD2. (2018)
  • Author(s): Taiji Iwasawa, Pu Zhang, Yuki Ohkawa, Hiroyuki Momota, Toshihiko Wakabayashi, Yuhsuke Ohmi, Robiul H. Bhuiyan, Keiko Furukawa, Koichi Furukawa
  • Journal Title: Int. J. Oncol. Volume: 52 Pages: 1255-1266
  • DOI: 10.3892/ijo.2018.4266
  • Peer Reviewed
• [Presentation] Analysis of control mechanisms of cancer microenvironments by sugar chains in colorectal cancer cells. (2021)
  • Author(s): Momoka Horiuchi, Yusuke Omi, Satoko Yamamoto, Hiroaki Kitazawa, Farhana Yesmin, Robiul Bhuiyan, Orie Tajima, Keiko Furukawa, Noboru Hashimoto, Koichi Furukawa
  • Organizer: 第80回 日本癌学会学術総会
• [Presentation] Changes of integrins in glycolipid-modified melanoma-derived exosomes. (2021)
  • Author(s): Kei Kaneko, Yuhsuke Ohmi, Mariko Kambe, Qi Li, Yesmin Farhana, Satoko Yamamoto, Yoko Kitaura, Takako Ito, Robiul H. Bhuiyan, Orie Tajima, Koichi Furukawa and Keiko Furukawa
  • Organizer: 第80回 日本癌学会学術総会
• [Presentation] Ganglioside GD2 enhances malignant properties of melanoma by co-operating with integrin. (2021)
  • Author(s): Farhana Yesmin, Robiul H. Bhuiyan, Yuhsuke Ohmi, Momoka Horiuchi, Tetsuya Okajima, Satoko Yamamoto, Keiko Furukawa, Koichi Furukawa
  • Organizer: 第80回 日本癌学会学術総会
• [Presentation] Unique effects of expression of asialo-series ganglioside GD1alpha in human cancer cell lines. (2021)
  • Author(s): Bhuiyan Robiul H., Farhana Yesmin, Yuji Kondo, Yuki Ohkawa, Yuhsuke Ohmi, Pu Zhang, Tetsuya Okajima, Keiko Furukawa, Koichi Furukawa
  • Organizer: 第80回 日本癌学会学術総会
• [Presentation] Ganglioside GD2 cooperate with integrin in the enhancement of malignant properties of melanoma cells. (2021)
  • Author(s): Farhana Yesmin, Robiul H. Bhuiyan, Yuhsuke Ohmi, Momoka Horiuchi, Tetsuya Okajima, Satoko Yamamoto, Kei Kaneko, Keiko Furukawa, Koichi Furukawa
  • Organizer: 第94回 日本生化学会大会
• [Presentation] スフィンゴ糖脂質による肝脂肪蓄積制御メカニズムの検討 (2021)
  • Author(s): 田島織絵、古川圭子、古川鋼一
  • Organizer: 第94回 日本生化学会大会
• [Presentation] ヒトグリオーマ細胞由来エクソソームに発現するガングリオシドの機能解析 (2021)
  • Author(s): 大海雄介、Li Qi、山本聡子、北浦洋子、伊藤多佳子、佐藤詩歩、金子 慶、神戸眞理子、イエスミン ファーハナ、田島織絵、モハンマド A ハスナット、河原敏男、古川圭子、古川鋼一
  • Organizer: 第94回 日本生化学会大会
• [Presentation] 初代培養アストロサイト上に発現するガングリオシドの役割 (2021)
  • Author(s): 佐藤詩歩、北浦洋子、伊藤多佳子、田島織絵、古川圭子、河原敏男、古川鋼一、大海雄介
  • Organizer: 第94回 日本生化学会大会
• [Presentation] Ganglioside GD3 enhances the expression of integrins on extracellular vesicles (EVs) to exert its functions. (2021)
  • Author(s): Kei Kaneko, Ohmi Yuhsuke, Kambe Mariko, Farhana Yesmin, Yamamoto Satoko, Kitaura Yoko, Ito Takako, Tajima Orie, Furukawa Koichi, Furukawa Keiko
  • Organizer: 第40回 日本糖質学会年会
• [Presentation] アストロサイトに発現するガングリオシドの機能解析と近傍分子の同定 (2021)
  • Author(s): 佐藤詩歩、北浦洋子、伊藤多佳子、田島織絵、小谷典弘、本家孝一、古川圭子、河原敏男、古川鋼一、大海雄介
  • Organizer: 第40回 日本糖質学会年会
• [Presentation] がん由来エクソソーム上に発現するガングリオシドのがん微小環境への影響 (2021)
  • Author(s): 大海雄介、Li Qi、山本聡子、北浦洋子、伊藤多佳子、佐藤詩歩、金子 慶、神戸眞理子、イエスミン ファーハナ、田島織絵、モハンマド A ハスナット、古川圭子、古川鋼一
  • Organizer: 第40回 日本糖質学会年会
• [Presentation] ヒト大腸癌細胞による糖脂質発現と機能の解析 (2021)
  • Author(s): 堀内萌々花、橋本登、大海雄介、山本聡子、北沢裕昭、Yesmin Farhana、田島織絵、古川圭子、古川鋼一
  • Organizer: 第40回 日本糖質学会年会
• [Presentation] Different expression of integrins in ganglioside-remodeling melanoma EVs. (2021)
  • Author(s): Kei Kaneko, Yuhsuke Ohmi, Mariko Kambe, Yesmin Farhana, Momoka Horiuchi, Yoko Kitaura, Takako Ito, Orie Tajima, Koichi Furukawa and Keiko Furukawa
  • Organizer: 国際EV学会（ISEV2021)
  • Int'l Joint Research
• [Presentation] Ganglioside GD2 enhances malignant properties of melanoma by co-operating with integrin. (2021)
  • Author(s): Farhana Yesmin, Robiul H. Bhuiyan, Yuhsuke Ohmi, Momoka Horiuchi, Tetsuya Okajima , Kei Kaneko, Keiko Furukawa, Koichi Furukawa
  • Organizer: 国際EV学会（ISEV2021)
  • Int'l Joint Research
• [Presentation] GD3/GD2-expressing glioma-derived EVs enhance malignant properties of gliomas, and regulate tumor microenvironments. (2021)
  • Author(s): Koichi Furukawa, Yuhsuke Ohmi, Qi Li, Hiroaki Kitasawa, Yesmin Farhana, Satoko Yamamoto, Yoko Kitaura, Takako Ito, Kei Kaneko, Mariko Kambe, Keiko Furukawa
  • Organizer: 国際EV学会（ISEV2021)
  • Int'l Joint Research
• [Presentation] ヒトグリオーマ細胞由来エクソソームの機能解析 (2021)
  • Author(s): 大海雄介、Li Qi、山本聡子、北浦洋子、伊藤多佳子、金子 慶、神戸眞理子、イエスミン ファーハナ、田島織絵、モハンマド A ハスナット、古川圭子、古川鋼一
  • Organizer: 第8回日本細胞外小胞学会学術集会
• [Presentation] ガングリオシド改変メラノーマ細胞由来EVsにおけるintegrin の発現パターンとがん形質機能の解析. (2021)
  • Author(s): 金子 慶、大海雄介、神戸真理子、ファーハナ イエスミン、山本聡子、北浦洋子、伊藤多佳子、田島織絵、古川鋼一、古川圭子
  • Organizer: 第8回日本細胞外小胞学会学術集会
• [Presentation] Extracellular vesicles secreted from melanoma cell lines contain high levels of integrins and similar profiles of ganglioside species with parent cells. (2020)
  • Author(s): Koichi Furukawa, Yuya Senoo, Mariko Kambe, Kazutaka Ikeda, Yuhsuke Ohmi, Satoko Yamamoto, Iori Kobayashi, Yuki Ohkawa, Keiko Furukawa
  • Organizer: International Society for Extracellular Vesicles (ISEV)
  • Int'l Joint Research
• [Presentation] スフィンゴ糖脂質による肝インスリンシグナル制御を介した脂肪肝抑制機構の検討. (2020)
  • Author(s): 田島織絵、古川圭子、古川鋼一
  • Organizer: 第93回日本生化学会
• [Presentation] Ganglioside GD2 enhances malignant properties of melanoma by co-operating with integrin. (2020)
  • Author(s): Farhana Yesmin, Robiul H. Bhuiyan, Yuhsuke Ohmi, Tetsuya Okajima, Satoko Yamamoto, Keiko Furukawa, Koichi Furukawa:
  • Organizer: 第79回日本癌学会総会
• [Presentation] Roles of asialo-series ganglioside GD1alpha in human cancer cell lines. (2020)
  • Author(s): Robiul Hasan Bhuiyan, Farhana Yesmin, Yuji Kondo, Yuki Ohkawa, Yuhsuke Ohmi, Pu Zhang, Tetsuya Okajima, Keiko Furukawa, Koichi Furukawa
  • Organizer: 第79回日本癌学会総会
• [Presentation] Novel cellular immunotherapy using GD2-specific CAR gene-modified allogeneic γ/δ-T cells against solid cancers. (2020)
  • Author(s): Hiroshi Fujiwara, Yasushi Akahori, Hiroshi Miwa, Linan Wang, Chisaki Hyuga, Yusuke Ohmi, Yoshimasa Tanaka, Keiko Furukawa, Koichi Furukawa, Yoshihiro Miyahara, Hiroshi Shiku
  • Organizer: 第82回日本血液学会学術集会
• [Presentation] 新規GD2特異的CAR遺伝子導入アロγ/δ-T 細胞の開発 (2020)
  • Author(s): 藤原 弘, 赤堀泰, 三輪啓志, 王立楠,日向千咲, 大海雄介, 宮原慶裕, 田中義正, 古川圭子, 古川鋼一, 珠玖 洋
  • Organizer: 第24回日本癌免疫学会
• [Presentation] 初代培養アストロサイト上に発現するガングリオシドの機能解析 (2020)
  • Author(s): 佐藤詩歩、北浦洋子、伊藤多佳子、古川圭子、河原敏男、古川鋼一、大海雄介
  • Organizer: 第39回日本糖質学会年会
• [Presentation] 大腸癌細胞の糖鎖発現解析と糖鎖改変の試み：癌微小環境の制御機構の解析をめざして (2020)
  • Author(s): 堀内萌々花、大海雄介、山本聡子、北沢裕昭、Yesmin Farhana, 田島織絵、古川圭子、古川鋼一
  • Organizer: 第39回日本糖質学会年会
• [Presentation] Roles of ganglioside GD3 in the regulation of microenvironment of gliomas. (2019)
  • Author(s): Pu Zhang
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] Targeting GD2 on cancer cells by an anti-GD2 antibody is promising in a variety of cancers: Challenge by CAR T. (2019)
  • Author(s): 古川鋼一
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] TNFα-and cAMP-signals oppositely regulate melanoma associated ganglioside GD3 synthase gene in human melanocytes. (2019)
  • Author(s): 竹内理香
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] Unique function of ganglioside GD2 in malignant melanomas. (2019)
  • Author(s): Farhana Yesmin
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] Roles of asialo-series ganglioside GD1alpha in human cancer cell lines. (2019)
  • Author(s): Robiul H.
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] マウスアストロサイト上に発現するガングリオシドの機能解析 (2019)
  • Author(s): 大海雄介
  • Organizer: 第92回日本生化学会大会
• [Presentation] 糖鎖改変マウスにおける脂肪肝抑制メカニズムの検討 (2019)
  • Author(s): 田島織絵
  • Organizer: 第92回日本生化学会大会
• [Presentation] シアル酸結合レクチンSiglec7のガングリオシドGD3認識に対するセラミド構造の影響 (2019)
  • Author(s): 橋本 登
  • Organizer: 第38回日本糖質学会
• [Presentation] 大腸癌におけるGb3の機能解析 (2019)
  • Author(s): 北沢裕昭
  • Organizer: 第38回日本糖質学会
• [Presentation] Extracellular vesicles secreted from ganglioside GD3-expressing cancer cell lines contain high levels of integrins: Roles of lipid rafts. (2019)
  • Author(s): Koichi Furukawa
  • Organizer: International Society for Extracellular Vesicles
  • Int'l Joint Research
• [Presentation] 糖鎖改変に伴う肝脂肪蓄積抑制の分子メカニズム (2018)
  • Author(s): 田島 織絵
  • Organizer: 第91回日本生化学大会
• [Presentation] 癌関連スフィンゴ糖脂質による細胞動態の分別的制御に関するタイムラプス解析 (2018)
  • Author(s): 古川 圭子
  • Organizer: 第91回日本生化学大会
• [Presentation] 癌転移におけるエクソソームの役割の解析 (2018)
  • Author(s): 児玉 佳輝
  • Organizer: 第91回日本生化学大会
• [Presentation] グリオーマーの微小環境調節におけるガングリオシドGD3の役割 (2018)
  • Author(s): 張 璞
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] 癌関連ガングリオシド合成酵素遺伝子の発現制御機構シグナルの解析：シグナル伝達阻害剤による検討 (2018)
  • Author(s): 竹内 理香
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] 糖鎖リモデリング癌細胞由来エキソソームの膜分子組成と分泌機構の解析 (2018)
  • Author(s): 小林 伊織
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] Roles of asialo-series ganglioside GD1alpha in human cancer cell lines (2018)
  • Author(s): Bhuiyan RH
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] IKK阻害剤WDLを用いたGD3合成酵素遺伝子の発現抑制効果の解析 (2018)
  • Author(s): 竹内 理香
  • Organizer: 第41回日本分子生物学会年会