| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We examined the involvement of endoplasmic reticulum (ER) stress in the induction of pathogenic T cell that causes systemic lupus erythematosus (SLE). We found that when SLE was induced in mice, the expression of unfolded protein response (UPR)-related molecules was increased in CD4 T cells. In these CD4 T cells, the gene expression of several molecules related to Wnt signaling pathway was changed. In vivo administration of ER stress inducer accelerated the production of autoantibody and autoimmune tissue injury. The result suggests that ER stress contributes to the pathogenesis of SLE by modulating the function of T cell.
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