| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
It is believed that the state of autophagy activity differs in each patient's cancer. Therefore, it is necessary to understand the biological significance of autophagy activity in cancer and to establish therapeutic strategies based on autophagy activity. In this study, we showed that inactivation of autophagy contributes to tumorigenesis and acquisition of metastatic potential in some cancer cells. We identified candidate biomarkers to determine the active state of autophagy in each patient cancer. Furthermore, we identified candidate molecules and effective small-molecule compounds as therapeutic targets for autophagy-inactivated cancers. These results provide a molecular basis for the establishment of new therapeutic strategies based on autophagy activity.
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