| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
There are two similarities between lifestyle-related diseases and cancer. The first point is that they are in a chronic inflammatory state, and the second point is that abnormal activation of mTORC1 is observed. Based on these similarities, we hypothesized that the transcription factor FOXK1, which is activated downstream of mTORC1, promotes both of lifestyle-related diseases and cancer. We identified that FOXK1 deficient mice were improved fatty liver-related inflammation, fibrosis, and tumorigenesis.
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