| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Wolfram syndrome (WS) is the most common genetic type I Diabetes mellitus. Molecular genetic studies show that 90% of WS patients carry a loss-of-function mutation in the WFS1 gene. It has recently been discovered that downregulation of Synoviolin (SYVN1) has been observed in Wfs1-deficient mice and lymphocytes from patients with WS. However, the downstream pathways involved after the degradation of SYVN1 remain unclear. In this study, we generated and analyze pancreatic β cell-specific SYVN1 knockout mice and found that Syvn1 deficiency in β cells causes insufficient insulin secretion.
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