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validity of precancerous lesion and research for pancreatic carcinogenesis

Research Project

Project/Area Number 18K06982
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 49020:Human pathology-related
Research InstitutionThe University of Tokyo

Principal Investigator

Tanaka Mariko  東京大学, 医学部附属病院, 病院講師 (50645710)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords膵臓癌 / 前癌病変 / ADM / 膵がん / 発がん機構 / EVI1 / microRNA
Outline of Final Research Achievements

Starting point of pancreatic carcinogenesis is acinar-to-ductal metaplasia(ADM). Previous research of ADM was mainly based on mouse model. I revealed that human ADM was occurred in inflammatory status and expressed several organ-specific transcriptional factors within one AMD lesion.
EVI1 was an important transcriptional factor for pancreatic carcinogenesis. EVI1-depletion caused the change of microRNA expression in pancreatic cancer/duct cells.

Academic Significance and Societal Importance of the Research Achievements

膵発がん初期の変化の記載はアプローチが難しくマウスモデルでの検討が主であるが、ヒト検体での現象を記述することで今後の膵癌研究の発展に貢献する意義を持つ。また、ゲノム研究の発展に伴いがんにおける遺伝子変異の描出が進んでいるが、遺伝子変異によらない発がん経路を見出すことは新たな診断・治療をもたらす可能性があると考えらえる。

Report

(2 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (6 results)

All 2020 2019

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (1 results)

  • [Journal Article] Eosinophilic cholangitis with eosinophilic granulomatosis with polyangiitis: A case report and review of the literature2020

    • Author(s)
      Yoshihara R, Komai T, Nagafuchi Y, Tsuchida Y, Shoda H, Tanaka M, Ushiku T, Fujio K.
    • Journal Title

      Allergology International

      Volume: 69 Issue: 1 Pages: 154-156

    • DOI

      10.1016/j.alit.2019.08.002

    • NAID

      130007788669

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term Risk of Malignancy in Branch-Duct Intraductal Papillary Mucinous Neoplasms.2020

    • Author(s)
      Oyama H, Tada M, Takagi K, Tateishi K, Hamada T, Nakai Y, Hakuta R, Ijichi H, Ishigaki K, Kanai S, Kogure H, Mizuno S, Saito K, Saito T, Sato T, Suzuki T, Takahara N, Morishita Y, Arita J, Hasegawa K, Tanaka M, Fukayama M, Koike K.
    • Journal Title

      Gastroenterology.

      Volume: 158 Issue: 1 Pages: 226-237

    • DOI

      10.1053/j.gastro.2019.08.032

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tumor Budding in Intrahepatic Cholangiocarcinoma: A Predictor of Postsurgery Outcomes.2019

    • Author(s)
      Tumor Budding in Intrahepatic Cholangiocarcinoma: A Predictor of Postsurgery Outcomes. Tanaka M, Yamauchi N, Ushiku T, Shibahara J, Hayashi A, Misumi K, Yasunaga Y, Morikawa T, Kokudo T, Arita J, Sakamoto Y, Hasegawa K, Fukayama M.
    • Journal Title

      Am J Surg Pathol.

      Volume: 43 Issue: 9 Pages: 1180-1190

    • DOI

      10.1097/pas.0000000000001332

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Novel Non-invasive Method for Predicting Liver Fibrosis by Quantifying the Hepatic Vein Waveform2019

    • Author(s)
      Soroida Y, Nakatsuka T, Sato M, Nakagawa H, Tanaka M, Yamauchi N, Wake T, Nakagomi R, Kinoshita MN, Minami T, Uchino K, Enooku K, Asaoka Y, Tanaka Y, Endo M, Nakamura A, Kobayashi T, Kurihara M, Hikita H, Sato M, Gotoh H, Iwai T, Fukayama M, Ikeda H, Tateishi R, Yatomi Y, Koike K.
    • Journal Title

      Ultrasound Med Biol.

      Volume: 45 Issue: 9 Pages: 2363

    • DOI

      10.1016/j.ultrasmedbio.2019.05.028

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Consensus Study of the Grading and Typing of Intraductal Papillary Mucinous Neoplasms of the Pancreas.2019

    • Author(s)
      Furukawa T, Fukushima N, Itoi T, Ohike N, Mitsuhashi T, Nakagohri T, Notohara K, Shimizu M, Tajiri T8, Tanaka M9, Yamaguchi H, Yanagisawa A, Sugiyama M, Okazaki K.
    • Journal Title

      Pancreas.

      Volume: 3(48) Issue: 4 Pages: 480-487

    • DOI

      10.1097/mpa.0000000000001270

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] 浸潤性膵管がんにおける micropapillary 成分の意義2019

    • Author(s)
      田中麻理子
    • Organizer
      第108回日本病理学会総会
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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