validity of precancerous lesion and research for pancreatic carcinogenesis
| Project/Area Number |
18K06982
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 49020:Human pathology-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Tanaka Mariko 東京大学, 医学部附属病院, 病院講師 (50645710)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 膵臓癌 / 前癌病変 / ADM / 膵がん / 発がん機構 / EVI1 / microRNA |
|---|
| Outline of Final Research Achievements |
Starting point of pancreatic carcinogenesis is acinar-to-ductal metaplasia(ADM). Previous research of ADM was mainly based on mouse model. I revealed that human ADM was occurred in inflammatory status and expressed several organ-specific transcriptional factors within one AMD lesion.
EVI1 was an important transcriptional factor for pancreatic carcinogenesis. EVI1-depletion caused the change of microRNA expression in pancreatic cancer/duct cells.
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| Academic Significance and Societal Importance of the Research Achievements |
膵発がん初期の変化の記載はアプローチが難しくマウスモデルでの検討が主であるが、ヒト検体での現象を記述することで今後の膵癌研究の発展に貢献する意義を持つ。また、ゲノム研究の発展に伴いがんにおける遺伝子変異の描出が進んでいるが、遺伝子変異によらない発がん経路を見出すことは新たな診断・治療をもたらす可能性があると考えらえる。
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Report
(2 results)
Research Products
(6 results)
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[Journal Article] Long-term Risk of Malignancy in Branch-Duct Intraductal Papillary Mucinous Neoplasms.2020
Author(s)
Oyama H, Tada M, Takagi K, Tateishi K, Hamada T, Nakai Y, Hakuta R, Ijichi H, Ishigaki K, Kanai S, Kogure H, Mizuno S, Saito K, Saito T, Sato T, Suzuki T, Takahara N, Morishita Y, Arita J, Hasegawa K, Tanaka M, Fukayama M, Koike K.
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Journal Title
Gastroenterology.
Volume: 158
Issue: 1
Pages: 226-237
DOI
Related Report
Peer Reviewed
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[Journal Article] Tumor Budding in Intrahepatic Cholangiocarcinoma: A Predictor of Postsurgery Outcomes.2019
Author(s)
Tumor Budding in Intrahepatic Cholangiocarcinoma: A Predictor of Postsurgery Outcomes. Tanaka M, Yamauchi N, Ushiku T, Shibahara J, Hayashi A, Misumi K, Yasunaga Y, Morikawa T, Kokudo T, Arita J, Sakamoto Y, Hasegawa K, Fukayama M.
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Journal Title
Am J Surg Pathol.
Volume: 43
Issue: 9
Pages: 1180-1190
DOI
Related Report
Peer Reviewed
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[Journal Article] A Novel Non-invasive Method for Predicting Liver Fibrosis by Quantifying the Hepatic Vein Waveform.2019
Author(s)
Soroida Y, Nakatsuka T, Sato M, Nakagawa H, Tanaka M, Yamauchi N, Wake T, Nakagomi R, Kinoshita MN, Minami T, Uchino K, Enooku K, Asaoka Y, Tanaka Y, Endo M, Nakamura A, Kobayashi T, Kurihara M, Hikita H, Sato M, Gotoh H, Iwai T, Fukayama M, Ikeda H, Tateishi R, Yatomi Y, Koike K.
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Journal Title
Ultrasound Med Biol.
Volume: 45
Issue: 9
Pages: 2363-2371
DOI
Related Report
Peer Reviewed
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[Journal Article] A Consensus Study of the Grading and Typing of Intraductal Papillary Mucinous Neoplasms of the Pancreas.2019
Author(s)
Furukawa T, Fukushima N, Itoi T, Ohike N, Mitsuhashi T, Nakagohri T, Notohara K, Shimizu M, Tajiri T8, Tanaka M9, Yamaguchi H, Yanagisawa A, Sugiyama M, Okazaki K.
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Journal Title
Pancreas.
Volume: 3(48)
Issue: 4
Pages: 480-487
DOI
Related Report
Peer Reviewed
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