Approaches to establish the algorithm for the pathologic diagnosis of lipogenic mesenchymal tumors
| Project/Area Number |
18K06989
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 49020:Human pathology-related
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 異型脂肪腫様腫瘍 / 脱分化型脂肪肉腫 / 異型紡錘形細胞・多形脂肪腫様腫瘍 / 筋肉内脂肪腫 / MDM2 / p16 / 高分化型脂肪肉腫 / HMGA2 / 異型紡錘形細胞脂肪腫様腫瘍 / 異型多形脂肪腫様腫瘍 / 同種性分化 / CDK4 / 脂肪性軟部腫瘍 / 脂肪肉腫 / 脂肪腫 / 病理診断 |
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| Outline of Final Research Achievements |
Liposarcoma, a malignant mesenchymal tumor showing lipogenic differentiation, should be diagnosed correctly and treated appropriately. In order to improve the accuracy of pathologic diagnosis of liposarcoma, several studies were carried out. The results are as follows: p16-immunostaining is useful for the differentiation between intramuscular lipoma and atypical lipomatous tumor (ALT); ALT and dedifferentiated liposarcoma (DDLPS) are characterized by the overexpression of MDM2 protein and the amplification of MDM2 gene; and ALT/DDLPS are more infiltrative than previously thought. Hopefully, the results will improve the diagnostic accuracy and the therapeutic strategies.
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| Academic Significance and Societal Importance of the Research Achievements |
脂肪肉腫は発生頻度の低い悪性腫瘍であり、その病理診断は必ずしも容易ではない。良性の脂肪腫や他の悪性軟部腫瘍と間違われることも稀ではなく、正しく病理診断を行うことが適切な治療の前提となる。今回の研究成果で、脂肪肉腫の診断に補助的診断手段（p16およびMDM2免疫染色など）の活用が有効であることを明らかにした。これを用いることで、脂肪肉腫の診断精度が向上し、適切な治療法を選択することが可能になると期待される。
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Boron neutron capture therapy for clear cell sarcoma2020
Author(s)
Fujimoto T., Suzuki M., Sudo T., Fujita I., Sakuma T., Sakurai Y., Hirose T., Morishita M., Takata T., Tamari Y., Tanaka Hi., Ando T., Kawamoto T., Hara H., Fukase N., Kawakami Y., Shigemoto R., Matsumoto T., Ichikawa H., Ono K., Kuroda R. yosuke、Akisue Toshihiro
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Journal Title
Applied Radiation and Isotopes
Volume: 166
Pages: 109324-109324
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Multi-marker algorithms based on CXCL13, IL-10, sIL-2 receptor, and β2-microglobulin in cerebrospinal fluid to diagnose CNS lymphoma.2020
Author(s)
Maeyama M, Sasayama T, Tanaka K, Nakamizo S, Tanaka H, Nishihara M, Fujita Y, Sekiguchi K, Kohta M, Mizukawa K, Hirose T, Itoh T, Kohmura E.
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Journal Title
Cancer Med
Volume: 9
Issue: 12
Pages: 3048-3048
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Soft tissue tumor with novel NR1D1-MAML1 fusion in a pediatric case2020
Author(s)
Komatsu M, Yamamoto N, Kawamoto T, Kawakami Y, Hara H, Uemura S, Nishimura N, Akisue T, Kuroda R, Iijima K, Jimbo N, Kanzawa M, Kajimoto K, Itoh T, Hirose T.
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Journal Title
Virchows Archiv
Volume: 477
Issue: 6
Pages: 891-895
DOI
Related Report
Peer Reviewed
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