| Project/Area Number |
18K07006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 49020:Human pathology-related
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| Research Institution | Saitama Children's Medical Center |
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Principal Investigator |
Nakazawa Atsuko 埼玉県立小児医療センター (臨床研究部), 臨床研究部, 部長 (90227736)
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| Co-Investigator(Kenkyū-buntansha) |
大島 孝一 久留米大学, 医学部, 教授 (50203766)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 小児リンパ腫 / 末梢性T細胞リンパ腫 / 遺伝子変異 / T-cell lymphoma / children / pathology / T-cel lymphoma / 腫瘍免疫 / リンパ腫 / 小児 |
|---|
| Outline of Final Research Achievements |
Nine cases of 1875 pediatric lymphoma cases were EBER-negative peripheral T-cell lymphomas (PTCL). Six cases were CD4-negative and CD8-positive, one case was double positive, and two cases were double negative. Seven cases were positive for cytotoxic molecules. All cases tested were included in a CCR3 pattern, which showed better prognosis compared to CXCR3 or CCR4 pattern. TNS1, ZFHX3,TET2, and NCOA2 mutation were detected, but no case had p53 or VAV1 gene alteration. JAK-STAT pathway related gene abnormality was not observed. It is suggested that pediatric EBER-negative PTCLs have much better prognosis than adult PTCL due to different genetic background.
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| Academic Significance and Societal Importance of the Research Achievements |
非常にまれな小児のEBER陰性末梢性T細胞リンパ腫(PTCL)についての研究で、成人とは異なる遺伝子背景、免疫微小環境を有することが示唆された。予後予測や治療の選択に関係するデータが得られた。
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