| Project/Area Number |
18K07023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 49020:Human pathology-related
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
菅井 有 岩手医科大学, 医学部, 教授 (20187628)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 胃癌 / 乳頭状腺癌 / 分子解析 / 免疫組織化学 / 胃乳頭状腺癌 / 分子病理 |
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| Outline of Final Research Achievements |
Clinicopathological, immunohistochemical and molecular analyses were performed in order to clarify the clinicopathological and molecular-biological characteristics of gastric papillary adenocarcinomas. Histolologically, the components of poorly differentiated adenocarcinoma, mucinous adenocarcinoma and micro papillary carcinoma were frequently found in papillary adenocarcinoma. The stratification between gastric papillary adenocarcinomas and conventional adenocarcinomas was difficult by the hierarchical cluster analysis using clinicopathological and molecular analyses. The relationship between the tumorigenesis of papillary adenocarcinoma and DNA methylation was not clarified.
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| Academic Significance and Societal Importance of the Research Achievements |
一般的に癌におけ る分子病理学的異常の差異は癌の生物学的病態と関連することから、癌の分子異常の確立は患者の治療を決定する上でも重要である。胃乳頭部癌は通常型胃癌と比較して、臨床病理学的および分子病理学的特徴が異なる可能性がある。胃乳頭状腺癌の臨床病理学的、分子病理学的特徴を確立することで、同腫瘍に罹患した患者さんの治療方針や取扱いに有用な知見が得られる可能性が示唆された。
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