Pathological features define human cancer physiology and elucdation of it's biological mechanism

• Project/Area Number: 18K07035
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49020:Human pathology-related
• Research Institution: National Cancer Center Japan
• Principal Investigator: Kojima Motohiro 国立研究開発法人国立がん研究センター, 臨床開発センター, ユニット長 (30338470)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: がん / がん微小環境 / 癌 / 腫瘍微小環境 / 物性 / 癌微小環境 / メカノトランスダクション / 癌関連線維芽細胞 / Transgelin / 大腸癌 / transgelin / 硬さ / 線維芽細胞

Outline of Final Research Achievements

We performed immunohistochemical analysis of Transgelin and α-SMA in 96 samples from surgically resected colorectal cancer patients underwent colectomy from February to December in 2012. Transgelin expression in cancer tissue was detected predominantly in cancer associated fibroblast, and co-expression of Transgelin and α-SMA were found in cancer stroma. On the other hand, Transgelin expression in cancer cells was faint. Transgelin expression also associated tumor elasticity and was found to be a prognostic factor. Based on these results, we finished to created knock-down constract of Transgelin.

Academic Significance and Societal Importance of the Research Achievements

腫瘍物性が腫瘍の悪性度、治療抵抗性に関わる事が報告されているが腫瘍組織は、がん細胞のみならず、血管、炎症細胞、線維芽細胞など多彩な細胞種から構成され、腫瘍物性を規定する細胞種や生物学的機構が分かっていない。また、生体の物性を計測する方法が少なく、臨床的有用性の報告が少ないため、ヒト腫瘍組織の物性を計測する標準的な手法が確立していない。本研究で我々が行ったヒト組織を使用した腫瘍物性の研究は、機器開発基盤情報となる腫瘍物性計測の有用性を示し、創薬開発基盤となる腫瘍物性構築における分子機構に Transgelinが関与するかを検討する環境が整備された。

Research Products

• [Int'l Joint Research] Moffitt Cancer Center/Tulane University School of Medicine(米国)
• [Int'l Joint Research] Moffitt Cancer Center./Tulane University School of Medicine./Roswell Park Comprehensive Cancer Center(米国)
• [Journal Article] Guidance for diagnosing autoimmune pancreatitis with biopsy tissues (2020)
  • Author(s): Notohara K, Kamisawa T, Fukushima N, Furukawa T, Tajiri T, Yamaguchi H, Aishima S, Fukumura Y, Hirabayashi K, Iwasaki E, Kanno A, Kasashima S, Kawashima A, Kojima M, Kubota K, Kuraishi Y, Mitsuhashi T, Naito Y, Naitoh I, Nakase H, Nishino T, Ohike N, Sakagami J, Shimizu K, Shiokawa M, Uehara T, et al.
  • Journal Title: Pathol Int Volume: 70 Issue: 10 Pages: 699-711
  • DOI: 10.1111/pin.12994
  • Peer Reviewed
• [Journal Article] Clinicopathological and molecular correlations in traditional serrated adenoma (2020)
  • Author(s): Sekine Shigeki、Yamashita Satoshi、Yamada Masayoshi、Hashimoto Taiki、Ogawa Reiko、Yoshida Hiroshi、Taniguchi Hirokazu、Kojima Motohiro、Ushijima Toshikazu、Saito Yutaka
  • Journal Title: Journal of Gastroenterology Volume: 55 Issue: 4 Pages: 418-427
  • DOI: 10.1007/s00535-020-01673-z
  • Peer Reviewed
• [Journal Article] Association between the mutational smoking signature and the immune microenvironment in lung adenocarcinoma (2020)
  • Author(s): Sato Kei、Mimaki Sachiyo、Yamashita Riu、Togashi Yosuke、Naito Tomoyuki、Udagawa Hibiki、Katsumata Shinya、Nakasone Shoko、Miyoshi Tomohiro、Tane Kenta、Aokage Keiju、Sugano Masato、Kojima Motohiro、Fujii Satoshi、Kuwata Takeshi、Ochiai Atsushi、Goto Koichi、Tsuboi Masahiro、Tsuchihara Katsuya、Ishii Genichiro
  • Journal Title: Lung Cancer Volume: 147 Pages: 12-20
  • DOI: 10.1016/j.lungcan.2020.06.029
  • Peer Reviewed
• [Journal Article] Machine learning-based histological classification that predicts recurrence of peripheral lung squamous cell carcinoma (2020)
  • Author(s): Koike Yutaro、Aokage Keiju、Ikeda Kosuke、Nakai Tokiko、Tane Kenta、Miyoshi Tomohiro、Sugano Masato、Kojima Motohiro、Fujii Satoshi、Kuwata Takeshi、Ochiai Atsushi、Tanaka Toshiyuki、Suzuki Kenji、Tsuboi Masahiro、Ishii Genichiro
  • Journal Title: Lung Cancer Volume: 147 Pages: 252-258
  • DOI: 10.1016/j.lungcan.2020.07.011
  • Peer Reviewed
• [Journal Article] Safety of endoscopic procedures with monopolar versus bipolar instruments in an ex vivo porcine model. (2020)
  • Author(s): Shinmura K, Ikematsu H, Kojima M, Nakamura H, Osera S, Yoda Y, Hori K, Oono Y, Ochiai A, Yano T.
  • Journal Title: BMC Gastroenterol. Volume: 20 Issue: 1 Pages: 27-27
  • DOI: 10.1186/s12876-020-1176-9
  • Peer Reviewed / Open Access
• [Journal Article] Novel stromal biomarker screening in pancreatic cancer patients using the in vitro cancer-stromal interaction model (2020)
  • Author(s): Nishida Yasunori、Nagatsuma Akiko Kawano、Kojima Motohiro、Gotohda Naoto、Ochiai Atsushi
  • Journal Title: BMC Gastroenterology Volume: 20 Issue: 1 Pages: 27-27
  • DOI: 10.1186/s12876-020-01556-w
  • Peer Reviewed
• [Journal Article] Clinical Utility of Histological and Radiological Evaluations of Tumor Necrosis for Predicting Prognosis in Pancreatic Cancer (2020)
  • Author(s): Kudo Masashi、Kobayashi Tatsushi、Gotohda Naoto、Konishi Masaru、Takahashi Shinichiro、Kobayashi Shin、Sugimoto Motokazu、Okubo Satoshi、Martin John、Cabral Horacio、Ishii Genichiro、Kojima Motohiro
  • Journal Title: Pancreas Volume: 49 Issue: 5 Pages: 634-641
  • DOI: 10.1097/mpa.0000000000001539
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The “histological replacement growth pattern” represents aggressive invasive behavior in liver metastasis from pancreatic cancer (2020)
  • Author(s): Watanabe Kazuo、Mitsunaga Shuichi、Kojima Motohiro、Suzuki Hidetaka、Irisawa Ai、Takahashi Hideaki、Sasaki Mitsuhito、Hashimoto Yusuke、Imaoka Hiroshi、Ohno Izumi、Ikeda Masafumi、Akimoto Tetsuo、Ochiai Atsushi
  • Journal Title: Cancer Medicine Volume: 9 Issue: 9 Pages: 3130-3141
  • DOI: 10.1002/cam4.2954
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of Upper Limb Physiological Features in Patients with Lymphedema After Breast Surgery Using Multiple Instruments (2020)
  • Author(s): Kojima Motohiro、Yamauchi Chisako、Oyamada Shunsuke、Hojo Takashi、Iwase Satoru、Naito Atsushi、Yamano Kazuhiko、Takahashi Shinichiro、Ochiai Atsushi
  • Journal Title: Lymphatic Research and Biology Volume: 18 Issue: 3 Pages: 239-246
  • DOI: 10.1089/lrb.2019.0039
  • Peer Reviewed
• [Journal Article] Comparison of morphological features in lymph node metastasis between pancreatic neuroendocrine neoplasms and pancreatic ductal adenocarcinomas (2020)
  • Author(s): Takahashi Daigoro、Kojima Motohiro、Morisue Ryo、Sugimoto Motokazu、Kobayashi Shin、Takahashi Shinichiro、Konishi Masaru、Gotohda Naoto、Ikeda Masafumi、Ochiai Atsushi
  • Journal Title: Pancreatology Volume: 20 Issue: 5 Pages: 936-943
  • DOI: 10.1016/j.pan.2020.05.013
  • Peer Reviewed
• [Journal Article] Survival Outcomes of Resected BRAF V600E Mutant Colorectal Liver Metastases: A Multicenter Retrospective Cohort Study in Japan (2020)
  • Author(s): Kobayashi S, Takahashi S, Takahashi N, Masuishi T, Shoji H, Shinozaki E, Yamaguchi T, Kojima M, Gotohda N, Nomura S, Yoshino T, Taniguchi H.
  • Journal Title: Ann Surg Oncol. Volume: 27(9) Issue: 9 Pages: 3307-3315
  • DOI: 10.1245/s10434-020-08817-8
  • Peer Reviewed
• [Journal Article] A Phase II Trial of Everolimus in Patients with Advanced Pancreatic Neuroendocrine Carcinoma Refractory or Intolerant to Platinum-Containing Chemotherapy (NECTOR Trial) (2020)
  • Author(s): Okuyama Hiroyuki、Ikeda Masafumi、Okusaka Takuji、Furukawa Masayuki、Ohkawa Shinichi、Hosokawa Ayumu、Kojima Yasushi、Hara Hiroki、Murohisa Gou、Shioji Kazuhiko、Asagi Akinori、Mizuno Nobumasa、Kojima Motohiro、Yamanaka Takeharu、Furuse Junji
  • Journal Title: Neuroendocrinology Volume: 110 Issue: 11-12 Pages: 988-993
  • DOI: 10.1159/000505550
  • Peer Reviewed
• [Journal Article] Relationship between surgical R0 resectability and findings of peripancreatic vascular invasion on CT imaging after neoadjuvant S-1 and concurrent radiotherapy in patients with borderline resectable pancreatic cancer (2020)
  • Author(s): Yasuta Sho、Kobayashi Tatsushi、Aizawa Hidetoshi、Takahashi Shinichiro、Ikeda Masafumi、Konishi Masaru、Kojima Motohiro、Kuno Hirofumi、Uesaka Katsuhiko、Morinaga Soichiro、Miyamoto Atsushi、Toyama Hirochika、Takakura Norihisa、Sugimachi Keishi、Takayama Wataru
  • Journal Title: BMC Cancer Volume: 20 Issue: 1 Pages: 1184-1184
  • DOI: 10.1186/s12885-020-07698-0
  • Peer Reviewed
• [Journal Article] Objective assessment of tumor regression in post-neoadjuvant therapy resections for pancreatic ductal adenocarcinoma: comparison of multiple tumor regression grading systems (2020)
  • Author(s): Matsuda Yoko、Ohkubo Satoshi、Nakano-Narusawa Yuko、Fukumura Yuki、Hirabayashi Kenichi、Yamaguchi Hiroshi、Sahara Yatsuka、Kawanishi Aya、Takahashi Shinichiro、Arai Tomio、Kojima Motohiro、Mino-Kenudson Mari
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 18278-18278
  • DOI: 10.1038/s41598-020-74067-z
  • Open Access / Int'l Joint Research
• [Journal Article] The potential application of PD-1 blockade therapy for early-stage biliary tract cancer. (2020)
  • Author(s): Umemoto K, Togashi Y, Arai Y, Nakamura H, Takahashi S, Tanegashima T, Kato M, Nishikawa T, Sugiyama D, Kojima M, Gotohda N, Kuwata T, Ikeda M, Shibata T, Nishikawa H.
  • Journal Title: Int Immunol. Volume: 32 Issue: 4 Pages: 273-281
  • DOI: 10.1093/intimm/dxz080
  • Peer Reviewed / Open Access
• [Journal Article] Ki67 expression and localization of T cells after neoadjuvant therapies as reliable predictive markers in rectal cancer. (2020)
  • Author(s): Imaizumi K, Suzuki T, Kojima M, Shimomura M, Sakuyama N, Tsukada Y, Sasaki T, Nishizawa Y, Taketomi A, Ito M, Nakatsura T.
  • Journal Title: Cancer Sci. Volume: 111 Issue: 1 Pages: 23-35
  • DOI: 10.1111/cas.14223
  • Peer Reviewed
• [Journal Article] Area of residual tumor (ART) can predict prognosis after post neoadjuvant therapy resection for pancreatic ductal adenocarcinoma. (2019)
  • Author(s): Okubo S, Kojima M, Matsuda Y, Hioki M, Shimizu Y, Toyama H, Morinaga S,
  • Journal Title: Sci Rep. Volume: 9 Issue: 1 Pages: 17145-17145
  • DOI: 10.1038/s41598-019-53801-2
  • Peer Reviewed / Open Access
• [Journal Article] Proportion of goblet cell is associated with malignant potential in invasive mucinous adenocarcinoma of the lung. (2019)
  • Author(s): Oki T, Aokage K, Ueda T, Sugano M, Tane K, Miyoshi T, Kojima M, Fujii S, Kuwata T, Ochiai A, Funai K, Tsuboi M, Ishii G.
  • Journal Title: Pathol Int. Volume: 69 Issue: 9 Pages: 526-535
  • DOI: 10.1111/pin.12853
  • Peer Reviewed
• [Journal Article] Dexamethasone Increases Cisplatin-Loaded Nanocarrier Delivery and Efficacy in Metastatic Breast Cancer by Normalizing the Tumor Microenvironment. (2019)
  • Author(s): Martin JD, Panagi M, Wang C, Khan TT, Martin MR, Voutouri C, Toh K, Papageorgis P, Mpekris F, Polydorou C, Ishii G, Takahashi S, Gotohda N, Suzuki T, Wilhelm ME, Melo VA, Quader S, Norimatsu J, Lanning RM, Kojima M, Stuber MD, Stylianopoulos T, Kataoka K, Cabral H.
  • Journal Title: ACS Nano. Volume: 13 Issue: 6 Pages: 6396-6408
  • DOI: 10.1021/acsnano.8b07865
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Growth patterns of small peripheral squamous cell carcinoma of the lung and their impacts on (2019)
  • Author(s): Omori T, Aokage K, Nakamura H, Katsumata S, Miyoshi T, Sugano M, Kojima M, Fujii S, Kuwata T, Ochiai A, Ikeda N, Tsuboi M, Ishii G.
  • Journal Title: J Cancer Res Clin Volume: 145 Issue: 7 Pages: 1773-1783
  • DOI: 10.1007/s00432-019-02937-9
  • Peer Reviewed
• [Journal Article] EIF3E‐RSPO2 and PIEZO1‐RSPO2 fusions in colorectal traditional serrated adenoma (2019)
  • Author(s): Hashimoto Taiki、Ogawa Reiko、Yoshida Hiroshi、Taniguchi Hirokazu、Kojima Motohiro、Saito Yutaka、Sekine Shigeki
  • Journal Title: Histopathology Volume: 印刷中 Issue: 2 Pages: 266-273
  • DOI: 10.1111/his.13867
  • Peer Reviewed
• [Journal Article] Clinicopathological features and endoscopic characteristics of inverted sessile serrated adenomas/polyps. (2019)
  • Author(s): Takashima K, Oono Y, Kojima M, Ikematsu H, Akimoto T, Yano T.
  • Journal Title: Endosc Int Open Volume: 7 Issue: 03 Pages: E330-E336
  • DOI: 10.1055/a-0820-2179
  • Peer Reviewed / Open Access
• [Journal Article] Recommendation of long-term and systemic management according to the risk factors in rectal NETs patients. (2019)
  • Author(s): Kojima M, Chen Y, Ikeda K, Tsukada Y, Takahashi D, Kawano S, Amemiya K, Ito M, Ohki R, Ochiai A.
  • Journal Title: Sci Rep Volume: 9 Issue: 1 Pages: 2040-2040
  • DOI: 10.1038/s41598-018-37707-z
  • Peer Reviewed / Open Access
• [Journal Article] Acquisition of WNT Pathway Gene Alterations Coincides With the Transition From Precursor Polyps to Traditional Serrated Adenomas. (2019)
  • Author(s): Hashimoto T, Ogawa R, Yoshida H, Taniguchi H, Kojima M, Saito Y, Sekine S.
  • Journal Title: Am J Surg Pathol Volume: 43 Issue: 1 Pages: 132-139
  • DOI: 10.1097/pas.0000000000001149
  • Peer Reviewed
• [Journal Article] Link between tumor-promoting fibrous microenvironment and an immunosuppressive microenvironment in stage I lung adenocarcinoma. (2018)
  • Author(s): Sakai T, Aokage K, Neri S, Nakamura H, Nomura S, Tane K, Miyoshi T, Sugano M, Kojima M, Fujii S, Kuwata T, Ochiai A, Iyoda A, Tsuboi M, Ishii G.
  • Journal Title: Lung Cancer Volume: 126 Pages: 64-71
  • DOI: 10.1016/j.lungcan.2018.11.006
  • Peer Reviewed
• [Journal Article] Effect of preoperative chemotherapy on distal spread of low rectal cancer located close to the anus. (2018)
  • Author(s): Kondo A, Tsukada Y, Kojima M, Nishizawa Y, Sasaki T, Suzuki Y, Ito M.
  • Journal Title: Int J Colorectal Dis. Volume: 33 Issue: 12 Pages: 1685-1693
  • DOI: 10.1007/s00384-018-3159-7
  • Peer Reviewed
• [Journal Article] Transgelin Protein Expression in Colorectal Cancer: A Clinicopathological Study (2018)
  • Author(s): Amemiya K, Kojima M, Nagatuma A, Kawano S, Takahashi M, Komiyama H, Sakamoto K, Ochiai A, Ito M
  • Journal Title: Allied J Clin Oncol Cancer Res. Volume: 1 Pages: 18-24
  • Peer Reviewed
• [Journal Article] Profiling the Tumour Immune Microenvironment in Pancreatic Neuroendocrine Neoplasms with Multispectral Imaging Indicates Distinct Subpopulation Characteristics Concordant with WHO 2017 Classification. (2018)
  • Author(s): Takahashi D, Kojima M, Suzuki T, Sugimoto M, Kobayashi S, Takahashi S, Konishi M, Gotohda N, Ikeda M, Nakatsura T, Ochiai A, Nagino M.
  • Journal Title: Sci Rep. Volume: 8 Issue: 1 Pages: 13166-13166
  • DOI: 10.1038/s41598-018-31383-9
  • Peer Reviewed / Open Access
• [Journal Article] Pathologic Evaluation of Surgical Margins in Pancreatic Cancer Specimens Using Color Coding With Tissue Marking Dyes. (2018)
  • Author(s): Takahashi D, Kojima M, Sugimoto M, Kobayashi S, Takahashi S, Konishi M, Gotohda N, Nagino M.
  • Journal Title: Pancreas Volume: 47 Issue: 7 Pages: 830-836
  • DOI: 10.1097/mpa.0000000000001106
  • Peer Reviewed
• [Journal Article] Steroidogenesis in ovarian-like mesenchymal stroma of hepatic and pancreatic mucinous cystic neoplasms (2018)
  • Author(s): Kumata H, Murakami K, Ishida K, Miyagi S, Arakawa A, Inayama Y, Kinowaki K, Ochiai A, Kojima K, Higashi M, Moritani S, Kuwahara K, Nakatani Y, Kajiura D, Tamura G, Kijima H, Yamakawa M, Shiraishi T, Inadome Y, Murakami K, Suzuki H, Sawai T, Unno M, Kamei T, Sasano H
  • Journal Title: Hepatol Res Volume: 48 Issue: 12 Pages: 989-999
  • DOI: 10.1111/hepr.13201
  • Peer Reviewed / Open Access
• [Journal Article] Superficially serrated adenoma: a proposal for a novel subtype of colorectal serrated lesion (2018)
  • Author(s): Hashimoto T, Tanaka Y, Ogawa R, Mori T, Yoshida H, Taniguchi H, Hiraoka N, Kojima M, Oono Y, Saito Y, Sekine S
  • Journal Title: Mod Pathol Volume: 31 Issue: 10 Pages: 1588-98
  • DOI: 10.1038/s41379-018-0069-8
  • Peer Reviewed
• [Presentation] 膵退形成癌はPD-L1を強発現する (2020)
  • Author(s): 森末 遼, 小嶋 基寛, 鈴木 利宙, 中面 哲也, 杉本 元一, 小林 信, 高橋 進一郎, 小西 大, 後藤田 直人
  • Organizer: 日本消化器外科学会総会75回
• [Presentation] 胆膵細胞診の精度向上を目指して AIを用いた胆管領域の細胞診における精度向上に繋がる情報収集 (2020)
  • Author(s): 説田 愛弓, 菅野 優, 成清 羊佳, 小林 隆樹, 枝 千春, 国仲 伸男, 小嶋 基寛, 石井 源一郎
  • Organizer: 日本臨床細胞学会
  • Invited
• [Presentation] 肉腫様肝細胞癌における腫瘍免疫微小環境の特徴 (2020)
  • Author(s): 森末 遼, 小嶋 基寛, 鈴木 利宙, 中面 哲也
  • Organizer: 日本癌学会総会
• [Presentation] EUS-FNBが診断に有用であったDurvalumabによる免疫関連膵炎の1例 (2020)
  • Author(s): 澁木 太郎, 橋本 裕輔, 小嶋 基寛, 江口 大樹, 合田 杏佑, 林 康平, 宮澤 祥一, 渡邊 一雄, 今岡 大, 池田 公史
  • Organizer: 消化器内視鏡学会
• [Presentation] 進行直腸癌に対する術前治療への免疫チェックポイント阻害剤の併用の可能性についての検討 (2020)
  • Author(s): 今泉 健, 鈴木 利宙, 小嶋 基寛, 下村 真奈美, 武冨 紹信, 伊藤 雅昭, 中面 哲也
  • Organizer: 日本がん免疫学会総会
• [Presentation] 非淡明細胞型腎細胞癌における腫瘍壊死の臨床病理学的特徴 (2020)
  • Author(s): 黒江 崇史, 菅野 雅人, 渡邊 麗子, 桑田 健, 小嶋 基寛, 中井 登紀子, 増田 均, 石井 源一郎
  • Organizer: 日本病理学会
• [Presentation] 傍乳頭領域発生の原発特定困難な腺癌に関する認識の共有と臨床病理学的検討 PBPCJアンケートと当院の検討 (2020)
  • Author(s): 小峰 竜二, 小嶋 基寛, 高橋 進一郎, 小西 大, 小林 信, 杉本 元一, 後藤田 直人
  • Organizer: 日本病理学会
• [Presentation] 肝外胆管癌に対する経乳頭的胆管細胞診・組織診の偽陰性に寄与する病理組織学的因子についての検討 (2020)
  • Author(s): 澁木 太郎, 小嶋 基寛, 渡邊 一雄, 佐々木 満仁, 高橋 秀明, 橋本 裕輔, 今岡 大, 大野 泉, 光永 修一, 池田 公史
  • Organizer: 日本病理学会
• [Presentation] 術前CT画像を用いた膵癌における組織学的な腫瘍内壊死の推測と課題 (2020)
  • Author(s): 工藤 雅史, 小嶋 基寛, 小林 達伺, 杉本 元一, 小林 信, 高橋 進一郎, 小西 大, 後藤田 直人
  • Organizer: 日本臨床外科学会
• [Presentation] 膵癌における腫瘍内壊死の形態学的・組織学的特徴と予後に関しての検討 (2020)
  • Author(s): 工藤 雅史, 小嶋 基寛, 石井 源一郎, 後藤田 直人, 高橋 進一郎, 小林 信, 杉本 元一, 小西 大
  • Organizer: 日本膵臓学会
• [Presentation] BRAF V600E変異を有する大腸癌肝転移に対する切除戦略 (2020)
  • Author(s): 小林 信, 高橋 進一郎, 小嶋 基寛, 杉本 元一, 小西 大, 伊藤 雅昭, 野村 尚吾, 吉野 孝之, 後藤田 直人, 谷口 浩也
  • Organizer: 日本外科学会
• [Presentation] 当院における消化管NET-G1/G2症例からの治療後フォローアップの検討 (2019)
  • Author(s): 奥村 圭, 小嶋 基寛
  • Organizer: 日本内分泌学会
• [Presentation] EUS-FNAによる診断に苦慮したepithelioid type gastrointestinal stromal tumorの一例 (2019)
  • Author(s): 説田 愛弓, 小林 隆樹, 枝 千春, 長谷川 恵美, 成清 羊佳, 菅野 優, 吉田 朗彦, 藤井 誠志, 小嶋 基寛
  • Organizer: 日本臨床細胞学会
• [Presentation] 癌の悪性度を規定する因子-癌微小環境および脈管内腫瘍塞栓の役割 大腸癌の増殖・伸展における線維芽細胞活性化の役割 (2019)
  • Author(s): 小嶋 基寛
  • Organizer: 日本乳癌学会総会
  • Invited
• [Presentation] 肉腫様肝細胞癌の臨床病理学的特徴と免疫学的微小環境に関する検討 (2019)
  • Author(s): 森末 遼, 小嶋 基寛, 鈴木 利宙, 杉本 元一, 小林 信, 高橋 進一郎, 小西 大, 後藤田 直人, 中面 哲也
  • Organizer: 日本病理学会総会
• [Presentation] Superficially serrated adenoma 大腸鋸歯状病変の新たなサブタイプの提案 (2019)
  • Author(s): 橋本 大輝, 田中 優作, 森 泰昌, 吉田 裕, 谷口 浩和, 平岡 伸介, 小嶋 基寛, 大野 康寛, 斎藤 豊, 関根 茂樹
  • Organizer: 日本病理学会総会
• [Presentation] 様々な症状を呈する膵・消化管神経内分泌腫瘍の診断と治療 (2019)
  • Author(s): 池田 公史, 小嶋 基寛, 笠島 敦子
  • Organizer: 日本内分泌学会
  • Invited
• [Presentation] More Objective Assessment of Tumor Regression in Post Neoadjuvant Therapy Resections for Pancreatic Ductal Adenocarcinoma:A Multicenter Study on Comparison of Multiple Tumor Regression Grading Systems (2019)
  • Author(s): Matsuda Y, Ohkubo S, Fukumura Y, Hirabayashi K, Yamaguchi H, Sahara Y, Kawanishi A, Takahashi S, Arai T, Kojima M, Mino-Kenudson M
  • Organizer: American pancreas association meeting
  • Int'l Joint Research
• [Presentation] 2.硬さセンサーを用いた乳がん術後リンパ浮腫計測に関する初期検討 (2019)
  • Author(s): 小嶋 基寛, 山内稚佐子
  • Organizer: 日本リンパ浮腫学会
• [Presentation] 3.Area of residual tumor (ART) measurement has a prognostic value in post neoadjuvant resections for pancreatic ductal adenocarcinoma (PDAC). (2019)
  • Author(s): Satoshi Okubo, Yoko Matsuda, Shinichiro Takahashi, Naoto Gotohda, Genichiro Ishii, Mari Mino-Kenudson, Motohiro Kojima
  • Organizer: USCAP 2019
  • Int'l Joint Research
• [Presentation] 4.Multiple cancer risk in rectal neuroendocrine tumors,and it's association with PHLDA3-LOH. (2019)
  • Author(s): Kojima M, Chen Y, Ikeda K, Tsukada Y, Takahashi D, Kawano S, Amemiya K, Ito M, Ohki R, Ochiai A
  • Organizer: USCAP 2019
  • Int'l Joint Research
• [Presentation] 内分泌腫瘍診断における基盤構築と臨床病理学的研究 (2018)
  • Author(s): 小嶋 基寛
  • Organizer: 日本臨床内分泌病理学会
• [Presentation] 5.Area of residual tumor is associated with clinical outcome in patients with pancreatic cancer after preoperative therapy (2018)
  • Author(s): Satoshi Okubo, Motohiro Kojima
  • Organizer: European Congress of Pathology 2018
  • Int'l Joint Research
• [Book] 膵臓を診る医師のための膵臓病理テキスト (2020)
  • Author(s): 中沼 安二、古川 徹、福村 由紀
  • Total Pages: 304
  • Publisher: 南江堂
  • ISBN: 9784524248797
• [Book] 【大腸腫瘍の病理診断の課題と将来展望】大腸粘膜内癌の診断基準と問題点 (2019)
  • Author(s): 小嶋 基寛
  • Total Pages: 6
  • Publisher: 医学書院
• [Book] がん生物学イラストレイテッド 第２版 膵がん (2019)
  • Author(s): 小嶋 基寛、江角 浩安
  • Total Pages: 10
  • Publisher: 羊土社
  • ISBN: 9784758120968
• [Book] 患者由来がんモデルを用いたがん研究実践ガイド 臨床検体取り扱い標準作業手順書、倫理、法規について (2019)
  • Author(s): 小嶋 基寛、落合 淳
  • Total Pages: 5
  • Publisher: 羊土社
  • ISBN: 9784758122429
• [Remarks] 国立がん研究センター 先端医療開発センター
  • URL: https://www.ncc.go.jp/jp/epoc/division/pathology/kashiwa/members/010/20170721143753.html
• [Remarks] がん組織の病理像と物性の関連を基にした診断法の開発とバイオマーカーの探索
  • URL: https://www.ncc.go.jp/jp/epoc/division/pathology/kashiwa/research_summary/040/20170721182523.html