| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Type III secretion system (T3SS)-2 is the most important virulence factor of Salmonella. In this study, we focused on macrophage cell death induced by T3SS-2 and identified T3SS-2 effectors involved in the induction of this cell death. In addition, the strain deleted all of these effectors did not elicit inflammation in mice. We also found that host factors B and C are involved in this cell death. However, we could not clarify the effect of cell death induction by these factors on the Salmonella virulence in a mouse model of colitis. Finally, we showed that cell death is induced in macrophages in Salmonella-infected mice.
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