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Single-B-cell dynamics analysis in simian immunodeficiency virus-specific neutralizing antibody induction

Research Project

Project/Area Number 18K07157
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 49060:Virology-related
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

Yamamoto Hiroyuki  国立感染症研究所, エイズ研究センター, グループ長 (80574615)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsHIV / SIV / 中和抗体 / B細胞 / Env / エイズ / 持続感染ウイルス
Outline of Final Research Achievements

A group of animals were identified in a rhesus macaque AIDS model which induce simian immunodeficiency virus-specific neutralizing antibody responses. Neutralizing antibody dynamics in vivo were scrutinized in these animals, in comparison with a control group. In result, B cell receptor-based approaches were implied to evoke skewing of estimating single-B-cell contributions in vivo via population isolation bias. In contrast, defining the spectrum of Env mutants and its correlation with specific B-cell responses appeared more clear,depicting a more holistic image of antiviral B-cell dynamics.

Academic Significance and Societal Importance of the Research Achievements

本研究では、サルエイズモデル中における稀少な動物の亜群を出発点として、サル免疫不全ウイルスに対する抗体の有効性、特にウイルスを中和する抗体(中和抗体)の意義を評価する方法を検索した。当初想定していた遺伝子解析ベースの手法と異なり、血漿検体ベースの実験手法でウイルス学的に解析し、さらに細胞ベースの解析結果と照合するほうがより正確に生体内の抗体応答の動態を評価できる可能性を見出した。この結果は、社会的な重要課題である、今後のウイルス制御戦略に対して必須の基礎的知見を与える結果である。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (12 results)

All 2021 2020 2019 2018

All Journal Article (5 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (7 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results)

  • [Journal Article] A Potent Anti-Simian Immunodeficiency Virus Neutralizing Antibody Induction Associated with a Germ Line Immunoglobulin Gene Polymorphism in Rhesus Macaques2021

    • Author(s)
      Matsuoka Saori、Kuwata Takeo、Ishii Hiroshi、Sekizuka Tsuyoshi、Kuroda Makoto、Sano Masato、Okazaki Midori、Yamamoto Hiroyuki、Shimizu Mikiko、Matsushita Shuzo、Seki Yohei、Saito Akatsuki、Sakawaki Hiromi、Hirsch Vanessa M.、Miura Tomoyuki、Akari Hirofumi、Matano Tetsuro
    • Journal Title

      Journal of Virology

      Volume: 95 Issue: 7

    • DOI

      10.1128/jvi.02455-20

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Therapeutic vaccine-mediated Gag-specific CD8+ T-cell induction under anti-retroviral therapy augments anti-virus efficacy of CD8+ cells in simian immunodeficiency virus-infected macaques2020

    • Author(s)
      Nakamura-Hoshi Midori、Takahara Yusuke、Matsuoka Saori、Ishii Hiroshi、Seki Sayuri、Nomura Takushi、Yamamoto Hiroyuki、Sakawaki Hiromi、Miura Tomoyuki、Tokusumi Tsuyoshi、Shu Tsugumine、Matano Tetsuro
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 11394-11394

    • DOI

      10.1038/s41598-020-68267-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Novel Immunogen Selectively Eliciting CD8(+) T Cells but Not CD4(+) T Cells Targeting Immunodeficiency Virus Antigens.2020

    • Author(s)
      Ishii H, Terahara K, Nomura T, Takeda A, Okazaki M, Yamamoto H, Tokusumi T, Shu T, Matano T.
    • Journal Title

      Journal of Virology

      Volume: 94 Issue: 8

    • DOI

      10.1128/jvi.01876-19

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] CD8+ T cell-based strong selective pressure on multiple simian immunodeficiency virus targets in macaques possessing a protective MHC class I haplotype2019

    • Author(s)
      Hau Trang Thi Thu、Nakamura-Hoshi Midori、Kanno Yoshiaki、Nomura Takushi、Nishizawa Masako、Seki Sayuri、Ishii Hiroshi、Kawana-Tachikawa Ai、Hall William W.、Nguyen Thi Lan Anh、Matano Tetsuro、Yamamoto Hiroyuki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 512 Issue: 2 Pages: 213-217

    • DOI

      10.1016/j.bbrc.2019.03.003

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] CD8+ Cytotoxic-T-Lymphocyte Breadth Could Facilitate Early Immune Detection of Immunodeficiency Virus-Derived Epitopes with Limited Expression Levels2019

    • Author(s)
      Tsukamoto Tetsuo、Yamamoto Hiroyuki、Matano Tetsuro
    • Journal Title

      mSphere

      Volume: 4 Issue: 1

    • DOI

      10.1128/msphere.00381-18

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Induction of cross-reactive simian immunodeficiency virus-specific neutralizing antibodies in macaques possessing specific germline B cell receptors2020

    • Author(s)
      Yamamoto H, Kuwata T, Matsuoka S, Ishii H, Sekizuka T, Kuroda M, Matsushita S, Seki Y, Sakawaki H, Miura T, Akari H, Matano T
    • Organizer
      22nd International Conference on Emerging Infectious Diseases in the Pacific Rim, AIDS Panel Agenda
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neutralizing antibodies against SIVmac239: T-cell synergism in protection and induction2019

    • Author(s)
      Yamamoto H
    • Organizer
      第33回日本エイズ学会学術集会
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Nef-specific cytolytic CD4+ T-cell responses in a viremic SIV controller receiving acute-phase neutralizing antibody passive infusion2019

    • Author(s)
      Hau TTT, Nomura T, Matano T, Yamamoto H
    • Organizer
      第67回日本ウイルス学会学術集会
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Protective and non-protective MHC-I haplotype-associated CD8+ T-cell responses in simian immunodeficiency virus-infected rhesus macaques2018

    • Author(s)
      Hau TTT, Nomura T, Seki S, Nakamura-Hoshi M, Ishii H, Matano T, Yamamoto H
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Characterization of neutralizing antibody responses induced in highly neutralization-resistant SIVmac239 infection2018

    • Author(s)
      Kanno Y, Nomura T, Hau TTT, Matano T, Yamamoto H
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Anti-SIV neutralizing antibodies: association with immune escape and controlling immune escape2018

    • Author(s)
      Yamamoto H
    • Organizer
      Immunological intervention of lentivirus infection: control versus escape, Center for AIDS Research Seminar, Kumamoto University
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] MHC-I haplotype-associated CD8+ T-cell responses in simian immunodeficiency virus-infected rhesus macaques2018

    • Author(s)
      Hau TTT, Nomura T, Seki S, Nakamura-Hoshi M, Ishii H, Naruse TK, Kimura A, Matano T, Yamamoto H
    • Organizer
      2nd Japan-Taiwan Joint Symposium on HIV/AIDS
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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