Differential control of the interefon and apoptotic responses against viral infection

• Project/Area Number: 18K07168
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49070:Immunology-related
• Research Institution: Hokkaido University (2020-2021); The University of Tokyo (2018-2019)
• Principal Investigator: Okazaki Tomohiko 北海道大学, 遺伝子病制御研究所, 准教授 (50724598)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: インターフェロン / ウイルス感染症 / アポトーシス / ウイルス感染 / Gla化

Outline of Final Research Achievements

We previously found a mechanism by which the host cells differentially utilized two different responses, type I interferon (IFN) production to limit viral replication and cell death to eliminate infected cells. However, it was not clear whether viral elimination could actually be achieved by the usage of two differential antiviral responses. In this study, we found that viral elimination is indeed achieved by the differential usage.

Academic Significance and Societal Importance of the Research Achievements

細胞内の翻訳後修飾を介した新たなシグナル伝達機構が存在する可能性を見出した。今後様々な生命現象において、この翻訳後修飾が機能を果たすことが明らかになると期待できる。また、ウイルス排除を担う新たな分子機構を見出すことが出来た。これらの分子機構をターゲットとした新たなウイルス感染症治療法や予防法の基盤を提供することで、成果を社会に還元できる。

Research Products

• [Journal Article] NUDT21 Links Mitochondrial IPS-1 to RLR-Containing Stress Granules and Activates Host Antiviral Defense (2020)
  • Author(s): Saeko Aoyama-Ishiwatari, Tomohiko Okazaki, Shun-ichiro Iemura, Tohru Natsume, Yasushi Okada, Yukiko Gotoh
  • Journal Title: The Journal of Immunology Volume: 206 Issue: 1 Pages: 154-163
  • DOI: 10.4049/jimmunol.2000306
  • Peer Reviewed / Open Access
• [Presentation] 翻訳後修飾を介した抗ウイルス防御機構の理解と応用 (2022)
  • Author(s): 岡崎朋彦
  • Organizer: 令和3年度「感染・免疫・がん・炎症」全国共同研究拠点シンポジウム
  • Invited
• [Presentation] 脳内ウイルス感染に対するIFN産生とアポトーシスの選択 (2021)
  • Author(s): 齋藤里歩、岡崎朋彦
  • Organizer: 第七回北海道大学部局横断シンポジウム
  • Invited
• [Presentation] Selective regulation of type I interferon and apoptosis and its relevance to brain protection against viral infection (2021)
  • Author(s): Tomohiko Okazaki
  • Organizer: KEY FORUM 2021 International Symposium
  • Int'l Joint Research / Invited
• [Presentation] Roles of embryonic microglia in Autism-like behaviors induced by maternal immune activation (2021)
  • Author(s): 岡崎朋彦
  • Organizer: 第44回日本分子生物学会年会
• [Presentation] ウイルス感染細胞におけるアポトーシスとインターフェロン産生の使い分け戦略 (2021)
  • Author(s): 岡崎朋彦
  • Organizer: 千里ライフサイエンスセミナー
  • Invited
• [Presentation] First line defense mechanisms against viral infection (2020)
  • Author(s): Tomohiko Okazaki, Yukiko Gotoh
  • Organizer: AMED-CREST International Symposium
  • Int'l Joint Research / Invited
• [Presentation] A division of labour for the type Ⅰ Interferon and apoptosis induction after viral infection (2019)
  • Author(s): Tomohiko Okazaki, Moe Inoue, Shinpei Toyoda, Yukiko Gotoh
  • Organizer: 17th International Congress of Immunology
  • Int'l Joint Research
• [Presentation] A division of labour for the type Ⅰ interferon and apoptosis induction after viral infection (2018)
  • Author(s): 岡﨑朋彦、井上萌、後藤由季子
  • Organizer: 第47回日本免疫学会学術集会
• [Presentation] A division of labour for the type Ⅰ interferon and apoptosis induction after viral infection (2018)
  • Author(s): 岡﨑朋彦、井上萌、後藤由季子
  • Organizer: TOLL2018
  • Int'l Joint Research
• [Book] ミトコンドリアダイナミクス (2021)
  • Author(s): 石原直忠ほか82名
  • Total Pages: 458
  • Publisher: エヌ・ティー・エス
  • ISBN: 9784860437466