| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The expression of MHC II molecules in intestinal epithelial cells and the expression of CD74 molecules that regulate MHC II molecules functions in intestinal epithelial cells are altered by different types of intestinal bacteria, and CD74 deficient mice show increased susceptibility to intestinal damage (irradiation-induced intestinal damage model and DSS-induced intestinal inflammation model). Furthermore, we generated mice lacking CD74 molecules specifically in small intestinal epithelial cells and analyzed the role of CD74 molecules in intestinal damage. The results revealed that CD74 molecules expressed on the cell surface of small intestinal epithelial cells play an important role in intestinal damage.
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