| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Using various combinations of known TCR/pHLA structural analysis data and docking simulations, we found that certain binding conditions were true for TCR-recognized peptide antigen-presenting molecule pairs, but not for non-recognized TCR/pHLA pairs. By scoring the presence or absence of binding conditions, we found that the TCR-recognized peptide antigen-presenting molecule pairs scored higher. Binding evaluation using structurally unknown TCR/pHLA pairs showed higher scores only for pairs with TCR-recognizable pHLA. It was also found that more accurate TCR/pHLA binding decisions can be made by performing exhaustive docking simulations.
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