Research Project
Grant-in-Aid for Scientific Research (C)
In this study, we investigated the mechanism of the decrease in phagocytic ability of macrophages accompanying aging. It was found that resident macrophages become pre-activated with aging, and their phagocytic ability decreases. In addition, it was suggested that the activation does not depend on the aging environment of the individual, but is caused by cell aging, and it was clarified that inactivation of p53 is involved in part of it.
本研究は、老化に伴って罹患率が著しく高くなる自己免疫疾患や多臓器機能不全の原因として、残存する死細胞に着目して展開した研究であり、老化に伴って死細胞が残存すると、持続的な炎症応答が誘発され、様々な疾病を起こしやすくなることを示し、その原因がマクロファージの活性化によるものであることを明らかにした。本研究の成果は、老化に伴うマクロファージの活性化を制御し、加齢に伴う様々な疾病の発症を抑えることを目指す足がかりにあるものと考えられる。
All 2021 2020 2019 2018
All Journal Article (6 results) (of which Int'l Joint Research: 4 results, Peer Reviewed: 6 results, Open Access: 4 results) Presentation (7 results) Book (1 results)
iScience
Volume: 24 Issue: 10 Pages: 103201-103201
10.1016/j.isci.2021.103201
J Clin Invest .
Volume: 6 Issue: 6 Pages: 3021-3037
10.1172/jci125505
120007017546
Sci. Rep.
Volume: 9 Issue: 1 Pages: 4702-4702
10.1038/s41598-019-41229-7
130007919173
Volume: 8 Issue: 1 Pages: 16199-16199
10.1038/s41598-018-34530-4
130007893014
Int. Immunopharmac.
Volume: 65 Pages: 44-49
10.1016/j.intimp.2018.09.037
Cancer Sci
Volume: 109 Issue: 11 Pages: 3532-3542
10.1111/cas.13796