Mechanism of IL-4-mediated immune regulation by group 2 innate lymphoid cells
| Project/Area Number |
18K07187
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 49070:Immunology-related
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 自然リンパ球 / IgE / IL-4 / 自然免疫 / アレルギー / ILC2 |
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| Outline of Final Research Achievements |
Group 2 innate lymphoid cells (ILC2) contribute to various immunological diseases including allergic disorders. Therefore, it is urgent to elucidate the activation mechanism of ILC2. In this study, we identified a novel pathway for ILC2 activation via the calcium (Ca2+) signaling pathway. In addition, IL-4 produced by ILC2 via Ca2+ signaling promoted increased allergic susceptibility by inducing antigen-nonspecific IgE production. Taken together, we clarified the mechanism of IL-4 production by ILC2 and the novel role of IL-4-mediated by ILC2 in the pathogenesis of allergy.
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| Academic Significance and Societal Importance of the Research Achievements |
本邦では、気管支喘息やアトピー性皮膚炎などのアレルギー性疾患は増加の一途をたどり、2人に1人が患うほど深刻化している。近年見出されたILC2は、多量の2型サイトカインを産生することで、アレルギー炎症を引き起こすことが明らかとなった。本研究では、アレルギー病態におけるILC2の新たな役割を見出したことから、アレルギー病態の理解に大きく貢献するとともに、新たな治療戦略を提案する成果を生み出した。
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Report
(4 results)
Research Products
(14 results)
