| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The Seed & Soil hypothesis is based on the idea that metastasized cancer cells (seed) can only grow in certain organs (soil), and that each cancer cell has its own organ to which it can easily metastasize. We focused on cancer stromal cells and hypothesized that the organ affinity of cancer is determined by the environment created by the stromal cells that exist in each organ. However, it is extremely difficult to obtain stromal cells for each metastatic lesion or cancer cell. In order to do this experimentally and efficiently, we tried to obtain organ-specific stromal cells by removing only cancer cells from tumor tissues by using mice expressing drug-resistant genes as carrier mice. We created transplantable, immunocompromised mice with the selection-drug resistant gene.
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