Regulome analysis of transcriptional regulatory network of immune suppressor cell differentiation in tumor micro environment

• Project/Area Number: 18K07204
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 50010:Tumor biology-related
• Research Institution: Tokyo Medical and Dental University (2020); Yokohama City University (2018-2019)
• Principal Investigator: Nakabayashi Jun 東京医科歯科大学, 統合教育機構, 教授 (80322733)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ネットワーク / 細胞分化 / 転写制御 / 遺伝子発現 / TAM / 転写制御ネットワーク / 細胞種特異的転写因子 / 運命決定 / モジュール / centrality / degree distribution / 階層構造 / ディープラーニング

Outline of Final Research Achievements

To reveal the transcriptional regulatory network of Tumor Associated Macrophage development, the expression patterns of hematopietic cells are investigated. The structural changes of transcriptional regulatory network

Academic Significance and Societal Importance of the Research Achievements

近年、発がんのプロセスにおいてTAMが非常に重要な役割を果たすことが明らかとなっている。本研究の成果は、TAMの分化を制御している転写制御ネットワークの構造を解明する第一歩となると考えられる。今後、TAM分化のメカニズムを明らかとし新規抗がん剤の開発に役立と考えられる。

Research Products

• [Journal Article] Structural changes in transcriptional regulatory networks for cell-type-specific gene expression during hematopoiesis. (2020)
  • Author(s): Nakabayashi J
  • Journal Title: Proceedings of 2020 24th International Conference on Circuits, Systems, Communications and Computers (CSCC) Volume: 1 Pages: 96-105
  • Peer Reviewed
• [Presentation] Structural changes in transcriptional regulatory networks for cell-type-specific gene expression during hematopoiesis. (2020)
  • Author(s): Nakabayashi jJ
  • Organizer: 24th International Conference on Circuits, Systems, Communications and Computers (CSCC)
  • Int'l Joint Research
• [Presentation] Structural changes in transcriptional regulatory networks for cell-type-specific gene exression during hematopoiesis (2020)
  • Author(s): Jun Nakabayashi
  • Organizer: 24th International Conference on Circuits, Systems, Communications and Computers
  • Int'l Joint Research
• [Presentation] Transcriptional Regulatory Networks (TRNs) of cell type specific gene expression in hematopoiesis (2018)
  • Author(s): 中林潤
  • Organizer: Society of Mathematical Biology
  • Int'l Joint Research