• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Innovative comprehensive investigation of the novel target molecule based on the mechanisms of liver metastasis in circulating tumor cells of pancreatic cancer.

Research Project

Project/Area Number 18K07222
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 50010:Tumor biology-related
Research InstitutionKyushu University (2020)
National Hospital Organization, Kyushu Cancer Center (2018-2019)

Principal Investigator

IGUCHI Tomohiro  九州大学, 医学研究院, 共同研究員 (30598959)

Co-Investigator(Kenkyū-buntansha) 杉町 圭史  独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 肝胆膵外科医長 (90452763)
古川 正幸  独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 副院長 (70601912)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords膵癌 / 循環腫瘍細胞 / 肝転移 / RNAシークエンス / シングルセル解析
Outline of Final Research Achievements

Circulating tumor cells (CTCs) of pancreatic cancer travel from portal vein to hepatic vein through the liver. However, most CTCs have a low metastatic potential and are spoiled in the liver. We expect that CTCs having a high metastatic potential are more frequently seen in hepatic vein than portal vein.
We compared the characteristics of a few CTCs obtained from portal vein and hepatic vein in the patients with pancreatic cancer and suggested that CTCs present in hepatic vein had a higher metastatic potential. Furthermore, there was not a little gene expression differences between CTCs of portal vein and hepatic vein by genome analysis.

Academic Significance and Societal Importance of the Research Achievements

肝静脈血中に含まれる循環腫瘍細胞に特徴的な遺伝子の変化は肝転移形成能の獲得に
つながる新規のドライバー遺伝子であり、治療標的となりうる可能性が高いと考え
られます。今回の研究で明らかとなりつつある門脈血と肝静脈血の循環腫瘍細胞の遺伝子発現の差異により、膵癌肝転移機構が解明されれば、循環腫瘍細胞そのものを治療標的とする創薬基盤を創出する可能性があります。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (11 results)

All 2020 2018 2017

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (6 results)

  • [Journal Article] Prognostic Impact of Geriatric Nutritional Risk Index in Patients With Synchronous Colorectal Liver Metastasis2020

    • Author(s)
      IGUCHI TOMOHIRO、SUGIMACHI KEISHI、MANO YOHEI、MOTOMURA TAKASHI、SUGIYAMA MASAHIKO、OTA MITSUHIKO、IKEBE MASAHIKO、ESAKI TAITO、YOSHIZUMI TOMOHARU、MORITA MASARU、MORI MASAKI、TOH YASUSHI
    • Journal Title

      Anticancer Research

      Volume: 40 Issue: 7 Pages: 4165-4171

    • DOI

      10.21873/anticanres.14416

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Preoperative Prognostic Nutritional Index Predicts the Development of Deep Venous Thrombosis After Pancreatic Surgery2020

    • Author(s)
      IGUCHI TOMOHIRO、SUGIMACHI KEISHI、MANO YOHEI、KONO MIHOKO、KAGAWA MASAKI、NAKANOKO TOMONORI、UEHARA HIDEO、SUGIYAMA MASAHIKO、OTA MITSUHIKO、IKEBE MASAHIKO、MORITA MASARU、TOH YASUSHI
    • Journal Title

      Anticancer Research

      Volume: 40 Issue: 4 Pages: 2297-2301

    • DOI

      10.21873/anticanres.14195

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of UHRF2 as a Negative Regulator of Epithelial-Mesenchymal Transition and Its Clinical Significance in Esophageal Squamous Cell Carcinoma.2018

    • Author(s)
      Iguchi T, Ueda M, Masuda T, Nambara S, Kidogami S, Komatsu H, Sato K, Tobo T, Ogawa Y, Hu Q, Saito T, Hirata H, Sakimura S, Uchi R, Hayashi N, Ito S, Eguchi H, Sugimachi K, Maehara Y, Mimori K
    • Journal Title

      Oncology

      Volume: 3 Issue: 3 Pages: 179-187

    • DOI

      10.1159/000488860

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serial mutational tracking in surgically resected locally advanced colorectal cancer with neoadjuvant chemotherapy.2018

    • Author(s)
      Sugimachi K, Sakimura S, Kuramitsu S, Hirata H, Niida A, Iguchi T, Eguchi H, Masuda T, Morita M, Toh Y, Maehara Y, Suzuki Y, Mimori K.
    • Journal Title

      Br J Cancer.

      Volume: 4 Issue: 4 Pages: 419-423

    • DOI

      10.1038/s41416-018-0208-5

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Subtotal Cholecystectomy as a Last Resort for Complicated Gallstone Disease.2017

    • Author(s)
      Sugimachi K, Iguchi T, Morita M, Toh Y.
    • Journal Title

      J Am Coll Surg

      Volume: 2 Issue: 2 Pages: 201-202

    • DOI

      10.1016/j.jamcollsurg.2017.10.011

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 膵・胆道合流異常のない同時性胆道系重複癌の2切除例2018

    • Author(s)
      井口友宏、杉町圭史、香川正樹、中司悠、杉山雅彦、吉田大輔、太田光彦、池部正彦、森田勝、藤也寸志
    • Organizer
      第55回九州外科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Three cases of synchronous double cancers of biliary tract2018

    • Author(s)
      Iguchi T, Sugimachi K
    • Organizer
      第30回日本肝胆膵外科学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 膵切除患者における深部静脈血栓症の発症予測因子の検討2018

    • Author(s)
      井口友宏、杉町圭史、香川正樹、中司悠、杉山雅彦、吉田大輔、太田光彦、池部正彦、森田 勝、藤也寸志
    • Organizer
      第73回日本消化器外科学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 肝胆膵外科領域における術前早期リハビリ介入の有用性2018

    • Author(s)
      井口友宏、杉町圭史、香川秀樹、中司悠、杉山雅彦、吉田大輔、太田光彦、池部正彦、森田勝、藤也寸志
    • Organizer
      第26回日本消化器関連学会週間(JDDW)
    • Related Report
      2018 Research-status Report
  • [Presentation] 膵・胆管合流異常のない同時性胆道重復癌の1切除例2018

    • Author(s)
      井口友宏、杉町圭史、瀧澤克美、田口健一、
    • Organizer
      第29回日本消化器癌発生学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 膵・胆管合流異常のない同時性胆道重複癌の1切除例2018

    • Author(s)
      井口友宏、杉町圭史
    • Organizer
      第51回 南区合同症例検討学術会
    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi