Phenotypic difference by the combination of both oncogenes and tumor suppressors in melanoma
Project/Area Number |
18K07227
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 50010:Tumor biology-related
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Research Institution | University of Toyama |
Principal Investigator |
Yokoyama Satoru 富山大学, 学術研究部薬学・和漢系, 准教授 (90613498)
|
Project Period (FY) |
2018-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | がん遺伝子 / がん抑制遺伝子 / 悪性黒色腫 / 細胞運動 / PTEN / 腫瘍微小環境 |
Outline of Final Research Achievements |
In this project, we focused on the difference of oncogenes and tumor suppressors even in similar melanoma derived from cutaneous and uveal tissue. To this end, we established the melanocytes overexpressing BRAF or GNA11, which is related to cutaneous melanoma or uveal melanoma, respectively. In addition, PTEN was knocked out in each established cells. We determined the increased tumor growth and cell migratory ability only in BRAF/PTEN-loss cells though the detailed mechanism is unknown.
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Academic Significance and Societal Importance of the Research Achievements |
死因の第一位が悪性新生物であり、今回の研究課題が腫瘍の発生の根幹に迫る研究内容であることから、学術的意義や社会的意義は十分あると考えられる。 現在詳細についての検討中であり、興味深い結果が期待される。
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Report
(4 results)
Research Products
(38 results)