| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In this project, we focused on the difference of oncogenes and tumor suppressors even in similar melanoma derived from cutaneous and uveal tissue.
To this end, we established the melanocytes overexpressing BRAF or GNA11, which is related to cutaneous melanoma or uveal melanoma, respectively. In addition, PTEN was knocked out in each established cells.
We determined the increased tumor growth and cell migratory ability only in BRAF/PTEN-loss cells though the detailed mechanism is unknown.
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