| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Clarification of the molecular mechanisms underlying angiogenesis can lead to a better understanding of various pathological conditions such as cancer and ischemic diseases. Recently, we found that CUL3-based E3 ubiquitin ligase expressed in vascular endothelial cells plays an important role in the progression of angiogenesis. However, intracellular mechanisms of CUL3-induced angiogenesis remained unclear. In the present study, we analyzed the phenotypes that are expressed by functional inhibition of the CUL3-based E3 ubiquitin ligase complex in vascular endothelial cells in vivo and in vitro. Our findings suggest that the CUL3-based E3 ubiquitin ligase is involved in RhoB-mediated actin depolymerization to accelerate angiogenesis. Functional inhibition of the CUL3-based E3 ubiquitin ligase may be a good target for the development of therapeutic drugs.
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