| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
A gene called Largen is ubiquitously expressed in most types of cells with low level, but increases cell size by modulating cellular mitochondrial content and ATP production upon over expression. To elucidate the relationships between mitochondrial activity and cancer onset/development, we investigated the effect of Largen-over expression in two different mouse models for leukemia caused by the distinct genetic disorders. The over expression of Largen extended the life span in one model mouse system, but had no effect on another one. The investigator found that the metabolic profiles and the rate of protein synthesis were altered in the cells derived from individual mouse models. The effect of Largen-over expression was also different in these models. A metabolome analysis revealed that particular metabolic pathways were activated by Largen-over expression.
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