Glycosylation and immunoglobulin signaling in malignant lymphoma
| Project/Area Number |
18K07240
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 50010:Tumor biology-related
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
Suzuki Osamu 福島県立医科大学, 医学部, 准教授 (00325953)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2022: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2021: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2018: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
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| Keywords | 糖鎖 / 悪性リンパ腫 / シアル酸 / レクチン / 細胞接着 / Igシグナル / イムノグロブリン |
|---|
| Outline of Final Research Achievements |
In adhesion assay using B cell lymphoma cell line, cell adhesion to galectins was enhanced by anti-IgM antibody in HBL-2 cells suggesting glycosylation of IgM may be associated with cell adhesion to galectins.
In adhesion assay using Burkitt lymphoma cell line, cell adhesion to galectins was enhanced by alteration of cell surface sialylation with sialic acid analogue.
These results suggested that cell surface sialic acids may be a target for therapy of human malignant lymphoma.
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| Academic Significance and Societal Importance of the Research Achievements |
ヒト悪性リンパ腫における糖鎖の研究はきわめてすくなく、不明な点が多い。
今回の成果は、世界的にも新しい知見であると考えられる。今後とも、悪性リンパ腫における糖鎖の研究を継続していくことは、大変貴重であると考えられた。
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Report
(6 results)
Research Products
(6 results)
