| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The mechanism of mTORC1 regulation by SmgGDS was revealed. Further, the phosphorylation sites of two proteins that are directly phosphorylated by mTORC1 were identified.
Analysis of malignant mesothelioma identified changes in the expression of genes involved in the regulation of mTORC1 activity, which were associated with the prognosis of mesothelioma patients. We found that suppression of SmgGDS expression inhibits mTORC1 activity in malignant mesothelioma cells and inhibits tumor growth in vitro and in vivo.
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