Identification of new biomarkers in chemoradiotherapy

• Project/Area Number: 18K07290
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 50020:Tumor diagnostics and therapeutics-related
• Research Institution: The University of Tokyo
• Principal Investigator: Miyagawa Ryu 東京大学, 医学部附属病院, 助教 (20721939)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ncRNA / がん / 放射線 / 放射線治療 / バイオマーカー / lncRNA / 非コードRNA

Outline of Final Research Achievements

The purpose of this study is to elucidate the new mechanisms of radiation-responsive non-coding RNA (ncRNA) for the establishment of a new biomarker in radiation therapy. I used X-ray-irradiated cancer-derived cultured cells. First, I identified the expressoion change of some ncRNAs by qPCR. Concurrently, I also identified the localization change of some ncRNAs and some proteins by FISH and IF methods. But I was not able to identify the interaction of those ncRNAs with proteins.

Academic Significance and Societal Importance of the Research Achievements

放射線照射によって発現が増加したncRNAをいくつか見つけることができました。特にその中でもほとんどまだ機能がわかっていない長いncRNAであるlong non-coding RNA（lncRNA）の中からもいくつか見出すことができました。作り出されているRNAのうち、高等生物になるほど一番多くの割合を占めているのがlncRNAです。今後さらなる研究でこのlncRNAが放射線治療に関わる詳細なメカニズムが同定できれば、社会的にインパクトが大きく、かつ正確性の高いバイオマーカーを確立できて、より治療予後が良好になることが期待でき、がん患者が増えている昨今において、社会的に有意義であると言えます。

Research Products

• [Journal Article] Glycated hemoglobin levels among workers who remained in the area evacuated after the Fukushima Daiichi Nuclear Plant disaster (2019)
  • Author(s): Mukai, T., Nozawa, Y., Miyagawa, R., Ohta, T., & Nakagawa, K.
  • Journal Title: Studies in Science and Technology Volume: 8 Issue: 2 Pages: 129-132
  • DOI: 10.11425/sst.8.129
  • NAID: 130007784734
  • ISSN: 2186-4942, 2187-1590
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between death attitude and risk perception of radiation (2019)
  • Author(s): Mukai, T., Miyagawa, R., Ohta, T., Nozawa, Y., Tamari, Y., & Nakagawa, K
  • Journal Title: Journal of Human Environmental Studies Volume: 17 Issue: 1 Pages: 25-30
  • DOI: 10.4189/shes.17.25
  • NAID: 130007687757
  • ISSN: 1348-5253, 1883-7611
  • Peer Reviewed
• [Presentation] Relationship analysis between geographical features and air dose rates using satellite data (2019)
  • Author(s): 太田 岳史、宮川 隆、向井 智哉、中川 恵一
  • Organizer: 日本放射線影響学会第 62 回 大会
• [Remarks]
  • URL: https://ja.wikipedia.org/wiki/%E5%AE%AE%E5%B7%9D%E9%9A%86
• [Remarks] 宮川隆のWikipediaページ
  • URL: https://ja.wikipedia.org/wiki/%E5%AE%AE%E5%B7%9D%E9%9A%86