Identification of new biomarkers in chemoradiotherapy
Project/Area Number |
18K07290
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 50020:Tumor diagnostics and therapeutics-related
|
Research Institution | The University of Tokyo |
Principal Investigator |
Miyagawa Ryu 東京大学, 医学部附属病院, 助教 (20721939)
|
Project Period (FY) |
2018-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | ncRNA / がん / 放射線 / 放射線治療 / バイオマーカー / lncRNA / 非コードRNA |
Outline of Final Research Achievements |
The purpose of this study is to elucidate the new mechanisms of radiation-responsive non-coding RNA (ncRNA) for the establishment of a new biomarker in radiation therapy. I used X-ray-irradiated cancer-derived cultured cells. First, I identified the expressoion change of some ncRNAs by qPCR. Concurrently, I also identified the localization change of some ncRNAs and some proteins by FISH and IF methods. But I was not able to identify the interaction of those ncRNAs with proteins.
|
Academic Significance and Societal Importance of the Research Achievements |
放射線照射によって発現が増加したncRNAをいくつか見つけることができました。特にその中でもほとんどまだ機能がわかっていない長いncRNAであるlong non-coding RNA(lncRNA)の中からもいくつか見出すことができました。作り出されているRNAのうち、高等生物になるほど一番多くの割合を占めているのがlncRNAです。今後さらなる研究でこのlncRNAが放射線治療に関わる詳細なメカニズムが同定できれば、社会的にインパクトが大きく、かつ正確性の高いバイオマーカーを確立できて、より治療予後が良好になることが期待でき、がん患者が増えている昨今において、社会的に有意義であると言えます。
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Glycated hemoglobin levels among workers who remained in the area evacuated after the Fukushima Daiichi Nuclear Plant disaster2019
Author(s)
Mukai, T., Nozawa, Y., Miyagawa, R., Ohta, T., & Nakagawa, K.
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Journal Title
Studies in Science and Technology
Volume: 8
Issue: 2
Pages: 129-132
DOI
NAID
ISSN
2186-4942, 2187-1590
Related Report
Peer Reviewed / Open Access
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[Journal Article] Relationship between death attitude and risk perception of radiation2019
Author(s)
Mukai, T., Miyagawa, R., Ohta, T., Nozawa, Y., Tamari, Y., & Nakagawa, K
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Journal Title
Journal of Human Environmental Studies
Volume: 17
Issue: 1
Pages: 25-30
DOI
NAID
ISSN
1348-5253, 1883-7611
Related Report
Peer Reviewed
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