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Evaluation of Boron Concentration in Refractory and Recurrent Tumors Using PET: Promotion of BNCT for Practical Use

Research Project

Project/Area Number 18K07296
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 50020:Tumor diagnostics and therapeutics-related
Research InstitutionOsaka University (2022)
Osaka Medical and Pharmaceutical University (2018-2021)

Principal Investigator

Isohashi Kayako  大阪大学, 大学院医学系研究科, 特任講師(常勤) (50598604)

Co-Investigator(Kenkyū-buntansha) 畑澤 順  大阪大学, 核物理研究センター, 特任教授 (70198745)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsPET / BNCT / FBPA / ホウ素濃度
Outline of Final Research Achievements

In boron neutron capture therapy (BNCT), the concentration of boron (10B) in tumor tissue can predict the therapeutic effect. In BNCT, boronophenylalanine (BPA), a phenylalanine (PA) labeled with 10B, can be used as a carrier to carry 10B to tumor cells. In BNCT, BPA BPA can be used as a carrier to carry 10B to PET imaging using a compound of this BPA labeled with the radionuclide 18F (FBPA) can visualize the distribution of 10B in the body. In this study, we investigated the relationship between the concentration of 10B in the blood of tumor patients and the concentration of 10B in the blood pool on PET images. The results showed that it is possible to estimate the 10B concentration in the blood from PET images, although there is a slight underestimation or overestimation depending on the PET-CT system used. We also found that 18F-FBPA PET accumulation could be visualized in many tumors, with some exceptions, and was useful in differentiating tumor from inflammation.

Academic Significance and Societal Importance of the Research Achievements

18F-FBPA PETはBNCTの適切な患者選択と正確な治療計画を可能にする。BNCTにおける正確な線量予測と有効性評価には、腫瘍内のホウ素濃度の予測が必要である。18F-FBPA PETの使用はBNCTの発展のために重要である。一部偽陰性・偽陽性の症例もあったが、18F-FBPA PETは多くの腫瘍で集積が可視化でき、さらに悪性腫瘍と良性病変の鑑別に有用な情報を与える。BNCTは再発/難治性腫瘍に対する放射線治療の1つであるが、18F-FBPA PET/CT診断により放射線治療後変化を含む炎症疾患と悪性腫瘍の区別が可能であり、確定診断のための侵襲的生検や切除の必要性を減らせる可能性がある。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (27 results)

All 2022 2021 2020 2019 2018

All Journal Article (9 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 9 results,  Open Access: 9 results) Presentation (18 results) (of which Int'l Joint Research: 5 results,  Invited: 5 results)

  • [Journal Article] Exploration of the threshold SUV for diagnosis of malignancy using 18F-FBPA PET/CT2022

    • Author(s)
      Kayako Isohashi, Yasukazu Kanai, Teruhito Aihara, Naonori Hu, Kentaro Fukushima, Ichiro Baba, Fumitoshi Hirokawa, Ryo Kakino, Tsuyoshi Komori, Keiji Nihei, Jun Hatazawa, Koji Ono
    • Journal Title

      Eur J Hybrid Imaging .

      Volume: 6 Issue: 1 Pages: 35-35

    • DOI

      10.1186/s41824-022-00156-z

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia2022

    • Author(s)
      Sugisawa Erika、Kondo Takeshi、Kumagai Yutaro、Kato Hiroki、Takayama Yasunori、Isohashi Kayako、Shimosegawa Eku、Takemura Naoki、Hayashi Yoshinori、Sasaki Takuya、Martino Mika?l M.、Tominaga Makoto、Maruyama Kenta
    • Journal Title

      Cell Reports

      Volume: 38 Issue: 10 Pages: 110462-110462

    • DOI

      10.1016/j.celrep.2022.110462

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Successful salvage surgery of the residual tumor after boron neutron capture therapy (BNCT): A case report2022

    • Author(s)
      Masaaki Higashino, Teruhito Aihara, Akiko Ozaki, Naonori Hu, Kayako Isohashi, Koji Ono, Keiji Nihei, Yoshitaka Kurisu, Ryo Kawata
    • Journal Title

      Appl Radiat Isot .

      Volume: 189 Pages: 110420-110420

    • DOI

      10.1016/j.apradiso.2022.110420

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comprehensive evaluation of dosimetric impact against position errors in accelerator-based BNCT under different treatment parameter settings.2022

    • Author(s)
      Kakino R, Hu N, Isohashi K, Aihara T, Nihei K, Ono K.
    • Journal Title

      Med Phys.

      Volume: 49 Issue: 8 Pages: 4944-4954

    • DOI

      10.1002/mp.15823

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of a treatment planning system developed for clinical boron neutron capture therapy and validation against an independent Monte Carlo dose calculation system2021

    • Author(s)
      Hu Naonori, Tanaka Hiroki, Kakino Ryo, Yoshikawa Syuushi, Miyao Mamoru, Akita Kazuhiko, Isohashi Kayako, Aihara Teruhito, Nihei Keiji, Ono Koji
    • Journal Title

      Radiation Oncology

      Volume: 16 Issue: 1 Pages: 243-243

    • DOI

      10.1186/s13014-021-01968-2

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Imaging Assessment of Tumor Response in the Era of Immunotherapy2021

    • Author(s)
      Nakata J, Isohashi K, Oka Y, Nakajima H, Morimoto S, Fujiki F, Oji Y, Tsuboi A, Kumanogoh A, Hashimoto N, Hatazawa J, Sugiyama H
    • Journal Title

      Diagnostics

      Volume: 5 Issue: 6 Pages: 1041-1041

    • DOI

      10.3390/diagnostics11061041

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Astrocyte metabolism in multiple sclerosis investigated by 1-C-11 acetate PET2020

    • Author(s)
      Kato, H. Okuno, T. Isohashi, K. Koda, T. Shimizu, M. Mochizuki, H. Nakatsuji, Y. Hatazawa, J.
    • Journal Title

      J Cereb Blood Flow Metab

      Volume: 41 Issue: 2 Pages: 369-379

    • DOI

      10.1177/0271678x20911469

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of the total distribution volume of 18 F-FBPA in normal tissues of healthy volunteers by non-compartmental kinetic modeling2020

    • Author(s)
      Victor Romanov, Kayako Isohashi, Galal Alobthani, Rouaa Beshr, Genki Horitsugi, Yasukazu Kanai, Sadahiro Naka, Tadashi Watabe, Eku Shimosegawa, Jun Hatazawa
    • Journal Title

      Ann Nucl Med

      Volume: 34 Issue: 3 Pages: 155-162

    • DOI

      10.1007/s12149-019-01427-9

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced immune reaction resulting from co-vaccination of WT1 helper peptide assessed on PET-CT2020

    • Author(s)
      Jun Nakata,Kayako Isohashi,Soyoko Morimoto,Ryota Itou,Takashi Kamiya,Ai Matsuura,Hiroko Nakajima,Fumihiro Fujiki,Sumiyuki Nishida,Yoshiko Hasii,Kana Hasegawa,Shinichi Nakatsuka,Naoki Hosen,Akihiro Tsuboi,Yoshihiro Oka,Atsushi Kumanogoh,Masaru Shibano,Satoru Munakata, Yusuke Oji, Jun Hatazawa,Haruo Sugiyama
    • Journal Title

      Medicine (Baltimore)

      Volume: 99 Issue: 39 Pages: e22417-e22417

    • DOI

      10.1097/md.0000000000022417

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Boron Neutron Capture Therapy (BNCT) and 18F-FBPA PET2022

    • Author(s)
      Kayako Isohashi
    • Organizer
      7th Osaka University-Samsung Medical Center Radiology Forum
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Therapeutic Potential of BNCT for Soft Tissue Sarcoma by 18F-FBPA PET/CT2022

    • Author(s)
      Kayako Isohashi, Yasukazu Kanai, Jun Hatazawa, Keiji Nihei, Koji Ono.
    • Organizer
      WFNMB2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison of [18F] FDG PET/CT and [18F] FBPA PET/CT for diagnostic ability in the differential diagnosis of malignant tumors and benign lesions.2022

    • Author(s)
      Kayako Isohashi, Yasukazu Kanai, Teruhito Aihara, Naonori Hu, Tsuyoshi Komori, Keiji Nihei, Jun Hatazawa, and Koji Ono.
    • Organizer
      SNM2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 悪性腫瘍と良性病変における18F-FBPA PET/CT画像診断能の評価2022

    • Author(s)
      礒橋佳也子, 金井泰和, 粟飯原輝人, 呼尚徳, 柿野諒、二瓶圭二, 畑澤順, 小野公二
    • Organizer
      第18回日本中性子捕捉療法学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 乳房外パジェット病へのBNCT適応拡大の可能性2022

    • Author(s)
      礒橋佳也子、金井泰和、柿野諒、呼尚徳、小森剛、二瓶圭二、小野公二
    • Organizer
      第4回日本核医学会近畿支部会
    • Related Report
      2022 Annual Research Report
  • [Presentation] F-18 FBPA PET/CTを用いた腫瘍と他病変における画像診断能の検証2021

    • Author(s)
      礒橋佳也子、金井泰和、粟飯原輝人、小森剛、二瓶圭二、畑澤順、小野公二
    • Organizer
      第61回日本核医学学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] FBPA-PETの血液プールとBNCTのBPA治療用量投与後の血中ホウ素濃度との比較検証2021

    • Author(s)
      礒橋佳也子、粟飯原輝人、金井泰和、呼尚徳、二瓶圭二、畑澤順、小野公二
    • Organizer
      第17回日本中性子捕捉療法学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 悪性腫瘍を鑑別する閾値SUV値の探索: F-18 FDG PET/CT vs. F-18 FBPA PET/CT2021

    • Author(s)
      礒橋佳也子、粟飯原輝人、金井泰和、小森剛、二瓶圭二、小野公二
    • Organizer
      第29回 北摂四医師会医学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 18F-FDG PET-CTの運用と実際ホウ素中性子捕捉療法(BNCT)のご紹介2021

    • Author(s)
      礒橋佳也子
    • Organizer
      FDG-PET WEBセミナー
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] BNCTにおける18F-FBPA PETの重要性2021

    • Author(s)
      礒橋佳也子
    • Organizer
      獣医学BNCT推進プロジェクト ホウ素中性子捕捉療法の獣医学分野への適応拡大に向けて
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Comparison of SUV in blood pools using FBPA PET and blood boron concentrations in BNCT2021

    • Author(s)
      Kayako Isohashi, Naonori Ko, Yasukazu Kanai, Teruhito Aihara, Keiji Nihei, Koji Ono
    • Organizer
      19th INTERNATIONAL CONGRESS ON NEUTRON CAPTURE THERAPY
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] FBPA PETを用いたBNCT時の血液と腫瘍のホウ素濃度の推定2020

    • Author(s)
      礒橋佳也子
    • Organizer
      第60回日本核医学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] ホウ素中性子捕捉療法(BNCT)とFBPA-PET診断について2020

    • Author(s)
      礒橋佳也子
    • Organizer
      大阪大学市民公開講座
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] FBPA PETを用いたBNCT時の血液と腫瘍のホウ素濃度の推定2019

    • Author(s)
      礒橋佳也子
    • Organizer
      第16回日本中性子捕捉療法学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 血液腫瘍モデルを用いたPET-CT評価2019

    • Author(s)
      礒橋佳也子
    • Organizer
      第59回日本核医学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] PET for BNCT2019

    • Author(s)
      Kayako Isohashi, Koji Ono
    • Organizer
      IAEA Workshop on BNCT
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] BPAとBNCTと18F-FBPA PETについて2019

    • Author(s)
      礒橋佳也子
    • Organizer
      AMED革新的がん医療実用化研究 ホウ素中性子捕捉療法(BNCT)への適用を指向した18F-FBPA PET診断技術の開発研究)のキックオフミーティングの講演会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Estimation of boron (10B) concentration in blood and tumor using FBPA PET in boron neutron capture therapy (BNCT)2018

    • Author(s)
      Kayako Isohashi
    • Organizer
      日本核医学学会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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