Analysis of the resistance mechanisms to molecular-targeting anticancer agents

• Project/Area Number: 18K07302
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 50020:Tumor diagnostics and therapeutics-related
• Research Institution: Keio University
• Principal Investigator: Sugimoto Yoshikazu 慶應義塾大学, 薬学部(芝共立), 教授 (10179161)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: がん分子標的治療 / 薬剤耐性 / がん幹細胞 / トランスポーター / がん分子標的治療薬 / がん分子標的薬 / AKT / シグナル伝達

Outline of Final Research Achievements

Upregulation of AKT3 was found in PLK inhibitor-resistant cells and AURK inhibitor-resistant cells. AKT3 lowered the frequency of multipolar spindle formation in mitotic cells. Upregulation of TNIK was found in BET inhibitor-resistant cells. TNIK was found to be involved in cell cycle control and drug resistance. 116/slug cells are SLUG-induced EMT cells with mesenchymal morphology and contain side population (SP) cells. BET inhibitors diminished the SP cells of 116/slug. 116/slug cells showed high sensitivity to GPX4 inhibitors. MINPP1 was shown to regulate the expression of multidrug efflux transporter P-glycoprotein.

Academic Significance and Societal Importance of the Research Achievements

近年、がん細胞の生存と増殖を制御する種々の分子に対する阻害薬が開発され、がん治療への応用が試みられている。本研究では、PLK阻害薬、AURK阻害薬、BET阻害薬およびその耐性細胞を用いて、これらの阻害薬の作用機構およびがん細胞の阻害薬耐性・感受性を決定する因子を明らかにした。また、上皮間葉転換、がん幹細胞、薬物排出トランスポーターの関与する阻害薬耐性・感受性についても新しい知見を得た。こうした研究を積み重ねることにより、がんに対してより有効な薬物療法が構築できると考えている。

Research Products

• [Int'l Joint Research] Johannes Gutenberg University/MicroCombiChem GmbH(ドイツ)
• [Int'l Joint Research] Johannes Gutenberg University(ドイツ)
• [Int'l Joint Research] Texas Tech University(米国)
• [Int'l Joint Research] Chongqing Medical University/Southwest Medical University/Foshan Women and Children's Hospital(中国)
• [Int'l Joint Research] University of Khartoum(スーダン)
• [Int'l Joint Research] University Federico II of Naples/University of Calabria/University of Salerno(イタリア)
• [Int'l Joint Research]
• [Int'l Joint Research] Johannes Gutenberg University(ドイツ)
• [Journal Article] The citrus fruit-derived flavanone glycoside narirutin is a novel potent inhibitor of organic anion-transporting polypeptides (2020)
  • Author(s): Morita T, Akiyoshi T, Sato R, Uekusa Y, Katayama K, Yajima K, Imaoka A, Sugimoto Y, Kiuchi F, Ohtani H.
  • Journal Title: J Agric Food Chem Volume: 68 Issue: 48 Pages: 14182-14191
  • DOI: 10.1021/acs.jafc.0c06132
  • Peer Reviewed
• [Journal Article] GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress (2020)
  • Author(s): Kato Yu、Kunimasa Kazuhiro、Takahashi Mizuki、Harada Ayaka、Nagasawa Ikuko、Osawa Masanori、Sugimoto Yoshikazu、Tomida Akihiro
  • Journal Title: Molecular Pharmacology Volume: 98 Issue: 6 Pages: 669-676
  • DOI: 10.1124/molpharm.120.000070
  • Peer Reviewed
• [Journal Article] Putative molecular determinants mediating sensitivity or resistance towards carnosic acid tumor cell responses (2020)
  • Author(s): Mahmoud Nuha、Saeed Mohamed E.M.、Sugimoto Yoshikazu、Klinger Anette、Fleischer Edmond、Efferth Thomas
  • Journal Title: Phytomedicine Volume: 77 Pages: 153271-153271
  • DOI: 10.1016/j.phymed.2020.153271
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effect of TNIK upregulation on JQ1-resistant human colorectal cancer HCT116?cells (2020)
  • Author(s): Takahashi Chihiro、Kondo Shingo、Sadaoka Kensuke、Ishizuka Shuhei、Noguchi Kohji、Kato Yu、Sugimoto Yoshikazu
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 530 Issue: 1 Pages: 230-234
  • DOI: 10.1016/j.bbrc.2020.06.136
  • Peer Reviewed
• [Journal Article] TAT1 upregulates glutaminase and modulates amino acids and glutathione metabolism. (2020)
  • Author(s): Kondo S, Kato Y, Minagawa S, Sugimoto Y.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 523 Issue: 3 Pages: 672-677
  • DOI: 10.1016/j.bbrc.2020.01.006
  • Peer Reviewed
• [Journal Article] SERCA and P-glycoprotein inhibition and ATP depletion are necessary for celastrol-induced autophagic cell death and collateral sensitivity in multidrug-resistant tumor cells. (2020)
  • Author(s): Xu SW, Law BYK, Qu SLQ, Hamdoun S, Chen J, Zhang W, Guo JR, Wu AG, Mok SWF, Zhang DW, Xia C, Sugimoto Y, Efferth T, Liu L, Wong VKW.
  • Journal Title: Pharmacological Research Volume: 153 Pages: 104660-104660
  • DOI: 10.1016/j.phrs.2020.104660
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] SNAIL- and SLUG-induced side population phenotype of HCT116 human colorectal cancer cells and its regulation by BET inhibitors. (2020)
  • Author(s): Kato Y, Kondo S, Itakura T, Tokunaga M, Hatayama S, Katayama K, Sugimoto Y.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 521 Issue: 1 Pages: 152-157
  • DOI: 10.1016/j.bbrc.2019.10.094
  • Peer Reviewed
• [Journal Article] pH-dependent transport kinetics of the human organic anion-transporting polypeptide 1A2 (2019)
  • Author(s): T. Morita, T Akiyoshi, R. Sato, K. Katayama, K. Yajima, H. Kataoka, A. Imaoka, Y. Sugimoto, H. Ohtani
  • Journal Title: Drug Metabolism and Pharmacokinetics Volume: 35 Issue: 2 Pages: 220-227
  • DOI: 10.1016/j.dmpk.2019.12.002
  • NAID: 50014558590
  • Peer Reviewed / Open Access
• [Journal Article] Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells. (2019)
  • Author(s): Saeed MEM, Boulos JC, Elhaboub G, Rigano D, Saab A, Loizzo MR, Hassan LEA, Sugimoto Y, Piacente S, Tundis R, Yagi S, Khalid H, Efferth T.
  • Journal Title: Phytomedicine Volume: 62 Pages: 152945-152945
  • DOI: 10.1016/j.phymed.2019.152945
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cytotoxicity of 40 Egyptian plant extracts targeting mechanisms of drug-resistant cancer cells. (2019)
  • Author(s): Hegazy MF, Abdelfatah S, Hamed AR, Mohamed TA, Elshamy AA, Saleh IA, Reda EH, Abdel-Azim NS, Shams KA, Sakr M, Sugimoto Y, Pare PW, Efferth T.
  • Journal Title: Phytomedicine Volume: 59 Pages: 152771-152771
  • DOI: 10.1016/j.phymed.2018.11.031
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Collateral sensitivity of drug-resistant ABCB5- and mutation-activated EGFR overexpressing cells towards resveratrol due to modulation of SIRT1 expression. (2019)
  • Author(s): Saeed MEM, Rahama M, Kuete V, Dawood M, Elbadawi M, Sugimoto Y, Efferth T.
  • Journal Title: Phytomedicine Volume: 59 Pages: 152890-152890
  • DOI: 10.1016/j.phymed.2019.152890
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Novel pharmacological effects of poly (ADP-ribose) polymerase inhibitor rucaparib on the lactate dehydrogenase pathway. (2019)
  • Author(s): Nonomiya Y, Noguchi K, Katayama K, Sugimoto Y.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 510 Issue: 4 Pages: 501-507
  • DOI: 10.1016/j.bbrc.2019.01.133
  • Peer Reviewed / Open Access
• [Journal Article] Synthesis of 5-hydroxy-3’,4’,7-trimethoxyflavone (HTMF) and related compounds and elucidation of their reversal effects on BCRP/ABCG2-mediated anticancer drug resistance. (2019)
  • Author(s): Tsunekawa R, KatayamaK, Hanaya K, Higashibayashi S, Sugimoto Y, Sugai T.
  • Journal Title: ChemBioChem Volume: 20 Issue: 2 Pages: 210-220
  • DOI: 10.1002/cbic.201800431
  • Peer Reviewed
• [Journal Article] Regorafenib-Induced Hand-Foot Skin Reaction is More Severe on the Feet than on the Hands (2018)
  • Author(s): Nonomiya Yuma、Yokokawa Takashi、Kawakami Kazuyoshi、Kobayashi Kazuo、Aoyama Takeshi、Takiguchi Tomomi、Sugisaki Takahito、Suzuki Kenichi、Suenaga Mitsukuni、Wakatsuki Takeru、Yamaguchi Kensei、Sugimoto Yoshikazu、Hama Toshihiro
  • Journal Title: Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics Volume: 印刷中 Issue: 5 Pages: 551-556
  • DOI: 10.3727/096504018x15291727589740
  • Peer Reviewed
• [Journal Article] Cytotoxicity of sesquiterpene alkaloids from Nuphar plants toward sensitive and drug-resistant cell lines. (2018)
  • Author(s): Fukaya M, Nakamura S, Hegazy MEF, Sugimoto Y, Hayashi N, Nakashima S, Yoshikawa M, Efferth T, Matsuda H.
  • Journal Title: Food & Function Volume: 9 Issue: 12 Pages: 6279-6286
  • DOI: 10.1039/c8fo01804a
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cytotoxicity of nimbolide towards multidrug-resistant tumor cells and hypersensitivity via cellular metabolic modulation. (2018)
  • Author(s): Mahmoud N, Saeed MEM, Sugimoto Y, Klauck SM, Greten HJ, Efferth T.
  • Journal Title: Oncotarget Volume: 9 Issue: 87 Pages: 35762-35779
  • DOI: 10.18632/oncotarget.26299
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells. (2018)
  • Author(s): Kato Y, Kunimasa K, Sugimoto Y, Tomida A.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 504 Issue: 4 Pages: 721-726
  • DOI: 10.1016/j.bbrc.2018.09.032
  • Peer Reviewed
• [Journal Article] Repurposing of Bromocriptine for Cancer Therapy. (2018)
  • Author(s): Seo EJ, Sugimoto Y, Greten HJ, Efferth T.
  • Journal Title: Frontiers in Pharmacology Volume: 9 Pages: 1030-1030
  • DOI: 10.3389/fphar.2018.01030
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells (2018)
  • Author(s): Fujiwara C, Muramatsu Y, Nishii M, Tokunaka K, Tahara H, Ueno M, Yamori T, Sugimoto Y, Seimiya H8
  • Journal Title: Sci Rep. Volume: 8 Issue: 1 Pages: 1-15
  • DOI: 10.1038/s41598-018-33139-x
  • Peer Reviewed / Open Access
• [Journal Article] Heat shock protein 90 inhibitors overcome the resistance to Fms-like tyrosine kinase 3 inhibitors in acute myeloid leukemia (2018)
  • Author(s): Katayama K, Noguchi K, Sugimoto Y.
  • Journal Title: Oncotarget Volume: 9 Issue: 76 Pages: 34240-34258
  • DOI: 10.18632/oncotarget.26045
  • Peer Reviewed / Open Access
• [Journal Article] Protein kinase C alpha-mediated phosphorylation of PIM-1L promotes the survival and proliferation of acute myeloid leukemia cells. (2018)
  • Author(s): Takami M, Katayama K, Noguchi K, Sugimoto Y.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 503 Issue: 3 Pages: 1364-1371
  • DOI: 10.1016/j.bbrc.2018.07.049
  • Peer Reviewed
• [Journal Article] Betulinic Acid Exerts Cytotoxic Activity Against Multidrug-Resistant Tumor Cells via Targeting Autocrine Motility Factor Receptor (AMFR). (2018)
  • Author(s): Saeed MEM, Mahmoud N, Sugimoto Y, Efferth T, Abdel-Aziz H.
  • Journal Title: Frontiers in Pharmacology Volume: 9 Pages: 481-481
  • DOI: 10.3389/fphar.2018.00481
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] FLT3-ITDによるintegrated stress response の誘導 (2021)
  • Author(s): 佐々木大河, 加藤優, 片山和浩, 近藤慎吾, 杉本芳一.
  • Organizer: 日本薬学会第141年会
• [Presentation] SLUG導入HCT116細胞に対するGPX4阻害剤の効果 (2021)
  • Author(s): 深澤ゆかり, 加藤優, 近藤慎吾, 杉本芳一.
  • Organizer: 日本薬学会第141年会
• [Presentation] Dextranによる多剤耐性関連輸送体の阻害効果 (2021)
  • Author(s): 森本かおり, 石井敬, 杉本芳一, 荻原琢男, 富田幹雄.
  • Organizer: 日本薬学会第141年会
• [Presentation] SLUG導入HCT116細胞におけるフェロトーシス感受性規定因子の解明 (2020)
  • Author(s): 加藤優, 近藤慎吾, 杉本芳一.
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] STAT１が関与する薬剤耐性とその克服 (2020)
  • Author(s): 近藤慎吾, 加藤優, 杉本芳一.
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] GZD824のGCN2-ATF4ストレス応答経路に対する阻害効果 (2020)
  • Author(s): 高橋瑞希, 加藤優, 國政和弘, 杉本芳一, 冨田章弘.
  • Organizer: 第24回日本がん分子標的治療学会学術集会
• [Presentation] SLUG導入HCT116細胞におけるxCTの発現上昇とフェロトーシス抵抗性 (2020)
  • Author(s): 加藤優, 近藤慎吾, 杉本芳一.
  • Organizer: 第24回日本がん分子標的治療学会学術集会
• [Presentation] CAGE transcriptome analysis reveals BCL2A1 upregulation in FLT3-ITD/D835 dual mutated AML cells harboring complex co-mutations. (2019)
  • Author(s): Yamatani K, Ai T, Saitoh K, Yang H, Suzuki K, Hori A, Murakami-Tonami, Y, Zhang W, Carter B, Kinjo S, Ikeo K, Katayama K, Sugimoto Y, Harada H, Miida T, Shah NP, Konopleva M, Hayashizaki Y, Andreeff M, Yoko Y.
  • Organizer: 61st ASH Annual Meeting
  • Int'l Joint Research
• [Presentation] High and low affinity kinetics of OATP2B1 - Inhibitory potency and pH-dependency of inhibitors -. (2019)
  • Author(s): Sato R, Akiyoshi T, Imaoka A, Katayama K, Sugimoto Y, Ohtani H.
  • Organizer: 日本薬物動態学会第34回年会
• [Presentation] Transactivation of CD274/PD-L1 Gene Promoter by KSHV RTA/ORF50 and Cellular SP1 Proteins. (2019)
  • Author(s): Noguchi K, Miyazawa M, Katayama K, Sugimoto Y.
  • Organizer: 第67回日本ウイルス学会
• [Presentation] かんきつ果汁中の新規 OATP2B1 阻害成分の探索とその阻害活性の定量的評価. (2019)
  • Author(s): 森田時生, 秋好健志, 矢島広大, 今岡鮎子, 植草義徳, 木内文之, 片山和浩, 杉本芳一, 大谷壽一.
  • Organizer: 第13回次世代を担う若手医療薬科学シンポジウム
• [Presentation] 上皮間葉転換に伴って誘導されるside population細胞の制御. (2019)
  • Author(s): 加藤優, 近藤慎吾, 杉本芳一.
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] ABCB5発現細胞におけるGLS発現の増大. (2019)
  • Author(s): 近藤慎吾, 加藤優, 片山和浩, 杉本芳一.
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] FLT3-ITDによるIntegrated Stress Response の制御. (2019)
  • Author(s): 佐々木大河, 加藤優, 近藤慎吾, 杉本芳一.
  • Organizer: 第63回日本薬学会関東支部大会
• [Presentation] P-glycoproteinの発現を制御するタンパク質の探索. (2019)
  • Author(s): 在津虎次郎, 近藤慎吾, 加藤優, 片山和浩, 杉本芳一.
  • Organizer: 第63回日本薬学会関東支部大会
• [Presentation] JQ1耐性細胞の解析. (2019)
  • Author(s): 齋藤優圭, 定岡健介, 近藤慎吾, 加藤優, 野口耕司, 杉本芳一.
  • Organizer: 第63回日本薬学会関東支部大会
• [Presentation] ウイルス転写因子K-RTAによるヒトCD274/PD-L1プロモーター活性化. (2019)
  • Author(s): 野口耕司, 宮澤雅典, 片山和浩, 杉本芳一.
  • Organizer: 第31回微生物シンポジウム
• [Presentation] 上皮間葉転換によるside population細胞の誘導解析. (2019)
  • Author(s): 加藤優, 片山和浩, 野口耕司, 杉本芳一.
  • Organizer: 第23回日本がん分子標的治療学会学術集会
• [Presentation] ABCB5発現細胞のBSO耐性機構. (2019)
  • Author(s): 近藤慎吾, 片山和浩, 野口耕司, 杉本芳一.
  • Organizer: 第23回日本がん分子標的治療学会学術集会
• [Presentation] 癌遺伝子BCR-ABLによる統合的ストレス応答制御機構 (2019)
  • Author(s): 加藤優, 杉本芳一, 冨田章弘.
  • Organizer: 日本薬学会第139年会
• [Presentation] JQ1耐性細胞におけるcyclin E1高発現に対するTNIKの関与 (2019)
  • Author(s): 高橋ちひろ, 野口耕司, 石塚周平, 片山和浩, 杉本芳一.
  • Organizer: 日本薬学会第139年会
• [Presentation] GSK3β阻害薬によるmultipolar spindleへの効果. (2019)
  • Author(s): 髙山柾, 野口耕司, 片山和浩, 杉本芳一.
  • Organizer: 日本薬学会第139年会
• [Presentation] ヒト有機アニオン輸送ポリペプチドOATP1A2のpH依存的輸送特性. (2019)
  • Author(s): 森田時生, 秋好健志, 今岡鮎子, 片山和浩, 杉本芳一, 大谷壽一.
  • Organizer: 日本薬学会第139年会
• [Presentation] BCRPを介した3’,4’-ジメトキシフラボン類の抗がん剤耐性克服作用. (2019)
  • Author(s): 恒川龍二, 片山和浩, 花屋賢悟, 東林修平, 杉本芳一, 須貝威.
  • Organizer: 日本薬学会第139年会
• [Presentation] BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells. (2018)
  • Author(s): Kato K, Kunimasa K, Sugimoto Y, Tomida A.
  • Organizer: The 23rd Japanese Foundation for Cancer Research International Symposium on Cancer Chemotherapy
  • Int'l Joint Research / Invited
• [Presentation] Poly (ADP-ribose) polymerase1 deficiency is not correlated with rucaparib and veliparib sensitivity in A2780 cells. (2018)
  • Author(s): Nonomiya Y, Noguchi K, Katayama K, Sugimoto Y.
  • Organizer: The 30th EORTC-NCI-AACR Molecular Targets and Cancer Therapeutics Symposium
  • Int'l Joint Research
• [Presentation] Heat shock protein 90 inhibitors overcome the resistance to various Fms-like tyrosine kinase 3 inhibitors. (2018)
  • Author(s): Katayama K, Noguchi K, Sugimoto Y.
  • Organizer: The 30th EORTC-NCI-AACR Molecular Targets and Cancer Therapeutics Symposium
  • Int'l Joint Research
• [Presentation] IL-10プロモーターにおけるK-RTAとSP1/3の相互作用解析 (2018)
  • Author(s): 宮澤雅典, 野口耕司, 片山和浩, 杉本芳一.
  • Organizer: 第66回日本ウイルス学会学術集会
• [Presentation] 患者由来胃がん細胞におけるCD44v陽性細胞の薬剤抵抗性への寄与とそのメカニズム (2018)
  • Author(s): 川上隆兵, 馬島哲夫, 熊谷厚志, 杉本芳一, 右田敏郎, 佐野武, 山口研成, 清宮啓之.
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] テロメラーゼ阻害剤MST-312の新規作用機序とその制がん効果を規定する因子. (2018)
  • Author(s): 藤原千明, 村松由起子, 矢守隆夫, 杉本芳一, 清宮啓之.
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] BCR-ABLはERストレス下におけるPERK-ATF4経路の活性化および細胞生存を制御する. (2018)
  • Author(s): 加藤優, 杉本芳一, 冨田章弘.
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] JQ1耐性HCT 116細胞におけるTNIKの役割. (2018)
  • Author(s): 野口耕司, 片山和浩, 杉本芳一.
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] Olaparib耐性細胞は、rucaparib、veliparibに対して感受性を示した. (2018)
  • Author(s): 野々宮悠真, 野口耕司, 片山和浩, 杉本芳一.
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] HSP90 阻害薬17-AAGはFLT3-ITD/D835変異型AML細胞の増殖を抑制する. (2018)
  • Author(s): 片山和浩, 野口耕司, 杉本芳一.
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] AKTによる染色体分離の制御. (2018)
  • Author(s): 髙山柾, 野口耕司, 野々宮悠真, 片山和浩, 杉本芳一.
  • Organizer: 第62回日本薬学会関東支部大会
• [Presentation] JQ1耐性細胞におけるcyclin E1の発現上昇に対するTNIKの関与 (2018)
  • Author(s): 高橋ちひろ, 野口耕司, 石塚周平, 片山和浩, 杉本芳一.
  • Organizer: 第62回日本薬学会関東支部大会
• [Presentation] ヒト小腸有機アニオン輸送ポリペプチド (OATP) 1A2, 2B1 の pH sensitive な輸送特性の解析. (2018)
  • Author(s): 森田時生, 佐藤稜, 秋好健志, 今岡鮎子, 片山和浩, 杉本芳一, 大谷壽一.
  • Organizer: 第62回日本薬学会関東支部大会
• [Presentation] olaparib耐性細胞を用いた耐性形質の解析. (2018)
  • Author(s): 野々宮悠真, 野口耕司, 片山和浩, 杉本芳一.
  • Organizer: 第22回日本がん分子標的治療学会学術集会
• [Presentation] アミノ酸飢餓により引き起こされるIntegrated Stress Response選択的な阻害剤の性状解析. (2018)
  • Author(s): 加藤優, 杉本芳一, 冨田章弘.
  • Organizer: 第22回日本がん分子標的治療学会学術集会
• [Presentation] Quizartinib 耐性急性骨髄性白血病における分子標的としてのHSP90. (2018)
  • Author(s): 片山和浩, 野口耕司, 杉本芳一.
  • Organizer: 第22回日本がん分子標的治療学会学術集会
• [Remarks] 化学療法学
  • URL: http://www.pha.keio.ac.jp/research/ct/index.html