| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Outline of Final Research Achievements |
We assessed mechanism of radiosensitizing effect of fluorescence live marker 5-aminolevulinic acid (ALA) in malignant brain tumor cell lines such as malignant gliomas and lymphomas. Lymphoma cells revealed high accumulation of 5-ALA induced protoporphyrin IX within the cytosol, and enhancement of delayed production of reactive oxygen species, and thus, 5-ALA lead to radiosensitizing effect in lymphoma cells. This phenomenon was also observed in lymphoma cells under the hypoxic condition.
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