Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Outline of Final Research Achievements |
We identified tankyrase, a poly(ADP-ribose) polymerase member, as a mediator of colorectal cancer stem cell maintenance. Furthermore, we showed that the AXIN-dependent regulation of c-KIT tyrosine kinase expression is a critical step in the cancer stem cell maintenance downstream of tankyrase. These data suggest that the inhibition of cancer stem cell fraction by targeting tankyrase could be a new strategy to enhance the effect of cancer chemotherapy.
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