Revealing the human hypothalamus-cerebral cortex network with fMRI and TMS techniques

• Project/Area Number: 18K07348
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 51010:Basic brain sciences-related
• Research Institution: Juntendo University
• Principal Investigator: Osada Takahiro 順天堂大学, 医学部, 准教授 (00456104)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 機能的磁気共鳴画像法（fMRI） / 視床下部 / 大脳皮質 / 皮質下領域 / 経頭蓋磁気刺激法（TMS） / fMRI / 機能的磁気共鳴画像法 / ネットワーク / 機能的領域分割 / 前頭葉 / 機能的結合性 / TMS / 経頭蓋磁気刺激法 / 食欲調節 / 自律神経

Outline of Final Research Achievements

We aimed to reveal the network between the hypothalamus and the cerebral cortex in humans. By using high spatial resolution functional magnetic resonance imaging (fMRI), we detected hypothalamic nuclei at the single-subject level, and identified the cerebral cortical areas connected with each detected hypothalamic nucleus. We also identified the network between the mammillary body and the subcortical areas, such as the hippocampus, tegmental nuclei, and anterior thalamus. Furthermore, to examine the causality of the brain areas and network, we used an intervention technique (transcranial magnetic stimulation; TMS) and revealed the essential role of the intraparietal sulcal area for response inhibition, one of executive cognitive functions.

Academic Significance and Societal Importance of the Research Achievements

本研究は、fMRIおよび介入手法により、(1) 視床下部でのそれぞれの核が形成している視床下部－大脳皮質ネットワーク、(2) 乳頭体－皮質下領域の神経ネットワーク、(3) 反応抑制に関わる大脳ネットワークおよび頭頂葉領域の因果性を明らかにした。これらは、自律神経系ネットワークや高次脳領域から相互作用の作動原理など、ヒト固有に存在する神経機構の解明につながると考えられる。また、介入手法による因果性の検証手法はさまざまな高次認知機能を支える脳ネットワークの解明へと広げられる。さらに、これらの成果は、脳機能脳障害の診断や治療法の確立につながることが期待される。

Research Products

• [Journal Article] Network centrality reveals dissociable brain activity during response inhibition in human right ventral part of inferior frontal cortex (2020)
  • Author(s): Uta Fujimoto, Akitoshi Ogawa, Takahiro Osada, Masaki Tanaka, Akimitsu Suda, Nobutaka Hattori, Koji Kamagata, Shigeki Aoki, Seiki Konishi
  • Journal Title: Neuroscience Research Volume: 433 Pages: 163-173
  • DOI: 10.1016/j.neuroscience.2020.03.010
  • Peer Reviewed
• [Journal Article] Dissociable Networks of the Lateral/Medial Mammillary Body in the Human Brain (2020)
  • Author(s): Tanaka Masaki、Osada Takahiro、Ogawa Akitoshi、Kamagata Koji、Aoki Shigeki、Konishi Seiki
  • Journal Title: Frontiers in Human Neuroscience Volume: 14 Pages: 228-228
  • DOI: 10.3389/fnhum.2020.00228
  • Peer Reviewed / Open Access
• [Journal Article] Functional Organization for Response Inhibition in the Right Inferior Frontal Cortex of Individual Human Brains (2020)
  • Author(s): Suda Akimitsu、Osada Takahiro、Ogawa Akitoshi、Tanaka Masaki、Kamagata Koji、Aoki Shigeki、Hattori Nobutaka、Konishi Seiki
  • Journal Title: Cerebral Cortex Volume: 30 Issue: 12 Pages: 6325-6335
  • DOI: 10.1093/cercor/bhaa188
  • Peer Reviewed / Open Access
• [Journal Article] Connectivity-based localization of human hypothalamic nuclei in functional images of standard voxel size (2020)
  • Author(s): Ogawa Akitoshi、Osada Takahiro、Tanaka Masaki、Kamagata Koji、Aoki Shigeki、Konishi Seiki
  • Journal Title: NeuroImage Volume: 221 Pages: 117205-117205
  • DOI: 10.1016/j.neuroimage.2020.117205
  • Peer Reviewed / Open Access
• [Journal Article] MRI-based visualization of rTMS-induced cortical plasticity in the primary motor cortex (2019)
  • Author(s): Tamura K†, Osada T†, Ogawa A, Tanaka M, Suda A, Shimo Y, Hattori N, Kamagata K, Hori M, Aoki S, Shimizu T, Enomoto H, Hanajima R, Ugawa Y, Konishi S († equal contribution)
  • Journal Title: PLOS One Volume: 14 Issue: 10 Pages: 0224175-0224175
  • DOI: 10.1371/journal.pone.0224175
  • Peer Reviewed / Open Access
• [Journal Article] More subjects are required for ventrolateral than dorsolateral prefrontal TMS because of intolerability and potential drop-out (2019)
  • Author(s): 3.Han S, Ogawa A, Osada T, Suda A, Tanaka M, Nanjo H, Shimo Y, Hattori N, Konishi S
  • Journal Title: PLOS One Volume: 14 Issue: 6 Pages: 0217826-0217826
  • DOI: 10.1371/journal.pone.0217826
  • Peer Reviewed / Open Access
• [Journal Article] An essential role of the intraparietal sulcus in response inhibition predicted by parcellation-based network (2019)
  • Author(s): Osada T, Ohta S, Ogawa A, Tanaka M, Suda A, Kamagata K, Hori M, Aoki S, Shimo Y, Hattori N, Enomoto H, Shimizu T, Hanajima R, Ugawa Y, Konishi S
  • Journal Title: Journal of Neuroscience Volume: 39 Pages: 2509-2521
  • Peer Reviewed
• [Journal Article] Striatal subdivisions that coherently interact with multiple cerebrocortical networks (2018)
  • Author(s): Ogawa A†, Osada T†, Tanaka M, Hori M, Aoki S, Nikolaidis A, Milham MP, Konishi S († equal contribution)
  • Journal Title: Human Brain Mapping Volume: 39 Issue: 11 Pages: 4349-4359
  • DOI: 10.1002/hbm.24275
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Within-subject correlation analysis to detect functional areas associated with response inhibition (2018)
  • Author(s): Yamasaki T, Ogawa A, Osada T, Jimura K, Konishi S
  • Journal Title: Frontiers in Human Neuroscience Volume: 12 Pages: 208-208
  • Peer Reviewed / Open Access
• [Presentation] Elucidation of functional connectivity patterns of the lateral/medial mammillary body using resting-state fMRI in the human brain (2021)
  • Author(s): Tanaka M, Osada T, Ogawa A, Han S, Kamagata K, Aoki S, Konishi S
  • Organizer: SfN Global Connectome 2021
  • Int'l Joint Research
• [Presentation] Precision mapping of the right inferior frontal cortex of human brains and its function for response inhibition at the single-subject level (2021)
  • Author(s): Suda A, Osada T, Ogawa A, Tanaka M, Kamagata K, Aoki S, Hattori, N, Konishi S
  • Organizer: SfN Global Connectome 2021
  • Int'l Joint Research
• [Presentation] Network centrality dissociates brain regions in right ventral IFC activated for response inhibition (2020)
  • Author(s): Ogawa A, Fujimoto U, Osada T, Tanaka M, Suda A, Hattori, N, Kamagata K, Aoki S, Konishi S
  • Organizer: OHBM 2020
  • Int'l Joint Research
• [Presentation] Dissociated brain regions for response inhibition in right ventral inferior frontal cortex using network centrality analysis (2020)
  • Author(s): Fujimoto U, Ogawa A, Osada T, Tanaka M, Suda A, Hattori N, Kamagata K, Aoki S, Konishi S
  • Organizer: 第43回 日本神経科学大会
• [Presentation] Spatial extent of repetitive TMS-induced plasticity in the primary motor cortex detected by resting-state fMRI (2019)
  • Author(s): Osada T, Tamura K, Ogawa A, Tanaka M, Suda A, Shimo Y, Hattori N, Kamagata K, Hori M, Aoki S, Shimizu T, Enomoto H, Hanajima R, Ugawa Y, Konishi S
  • Organizer: Neuroscience 2019
  • Int'l Joint Research
• [Presentation] Essentiality of the intraparietal sulcus for response inhibition revealed by fMRI and TMS (2019)
  • Author(s): Osada T, Ohta S, Ogawa A, Tanaka M, Suda A, Kamagata K, Hori M, Aoki S, Shimo Y, Hattori N, Shimizu T, Enomoto H, Hanajima R, Ugawa Y, Konishi S
  • Organizer: 第3回 ヒト脳イメージング研究会
• [Presentation] Causal role of the posterior parietal cortex for response inhibition revealed by fMRI and TMS (2019)
  • Author(s): Osada T, Ohta S, Ogawa A, Tanaka M, Suda A, Kamagata K, Hori M, Aoki S, Shimo Y, Hattori N, Shimizu T, Enomoto H, Hanajima R, Ugawa Y, Konishi S
  • Organizer: NEURO2019
• [Presentation] Necessity of the posterior parietal cortex in response inhibition revealed by fMRI and TMS (2019)
  • Author(s): Osada T, Ohta S, Ogawa A, Tanaka M, Suda A, Kamagata K, Hori M, Aoki S, Shimo Y, Hattori N, Shimizu T, Enomoto H, Hanajima R, Ugawa Y, Konishi S
  • Organizer: OHBM 2019 Annual Meeting
  • Int'l Joint Research
• [Presentation] Functional connectivity changes after rTMS used to detect plasticity decline associated with obesity (2019)
  • Author(s): Han S, Osada T, Ogawa A, Tanaka M, Hori M, Aoki S, Shimizu T, Enomoto H, Hanajima R, Ugawa Y, Konishi S
  • Organizer: FAOPS 2019
  • Int'l Joint Research
• [Presentation] Causally essential neural network for performing metacognitive judgement on experience and ignorance in primates (2018)
  • Author(s): Miyamoto K, Setsuie R, Osada T, Miyashita Y
  • Organizer: Neuroscience 2018
  • Int'l Joint Research
• [Presentation] Localisation and reversible silencing of metacognition networks for experienced and non-experienced events in primates (2018)
  • Author(s): Miyamoto K, Setsuie R, Osada T, Miyashita Y
  • Organizer: 11th FENS Forum of Neuroscience
  • Int'l Joint Research
• [Presentation] Striatal subdivisions interacting with multiple cerebrocortical networks (2018)
  • Author(s): 小川 昭利、長田 貴宏、田中 政輝、堀 正明、青木 茂樹、Aki Nikolaidis、Michael P Milham、小西 清貴
  • Organizer: 第2回 ヒト脳イメージング研究会
• [Presentation] Causal role of the frontopolar cortex for metacognitive judgement on non-experienced events in primates (2018)
  • Author(s): 宮本 健太郎、節家 理恵子、長田 貴宏、宮下保司
  • Organizer: 第41回 日本神経科学大会