Visual attention and visual awareness in a monkey model of unilateral spatial neglect

• Project/Area Number: 18K07359
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 51020:Cognitive and brain science-related
• Research Institution: Hokkaido University (2019-2020); National Institute for Physiological Sciences (2018)
• Principal Investigator: Yoshida Masatoshi 北海道大学, 人間知・脳・AI研究教育センター, 特任准教授 (30370133)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: サリエンス / 機能的結合 / サッケード / マイクロサッケード / 視覚的注意 / 視覚的気づき

Outline of Final Research Achievements

The aim of this study is to understand the mechanisms of the symptoms and recovery from unilateral spatial neglect. For this purpose, we examined whether the damage in the brain replicate the symptoms of unilateral spatial neglect in macaque and marmoset monkeys and investigated the mechanism of the symptoms. We developed behavioral methods for testing visual attention and visual awareness. We also identified attention networks using resting-state functional magnetic resonance imaging in macaque monkeys. We also developed behavioral methods for testing visual attention with free-viewing and identified attention networks using electrocorticograms in marmoset monkeys.

Academic Significance and Societal Importance of the Research Achievements

半側空間無視とは脳梗塞などで主に右大脳半球が損傷したときにしばしば起こる、損傷と反対側の空間の感覚刺激に対する反応が欠如・低下する現象のことを指す。半側空間無視では体の半分側の空間に注意が向かないためにリハビリテーションが困難であるという問題がある。本研究課題は霊長類でのモデル動物を作ることで、ヒトを対象とした研究だけでは不可能な神経活動のレベルでの症状の解明を行うことで、あらたな介入方法や機能回復方法を開発することを目指した。その結果、これまでは解剖学的な相同性しかわかっていなかった注意ネットワークがマカクザル、マーモセットでも機能していることを示唆する結果を得た。

Research Products

• [Int'l Joint Research] Centre for Integrative Neuroscience(ドイツ)
• [Int'l Joint Research] Centre for Integrative Neuroscience(ドイツ)
• [Journal Article] Properties of visually guided saccadic behavior and bottom-up attention in marmoset, macaque, and human (2021)
  • Author(s): Chen CY, Matrov D, Veale R, Onoe H, Yoshida M, Miura K, Isa T
  • Journal Title: Journal of neurophysiology Volume: 125 Issue: 2 Pages: 437-57
  • DOI: 10.1152/jn.00312.2020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dissociable Cortical and Subcortical Mechanisms for Mediating the Influences of Visual Cues on Microsaccadic Eye Movements (2021)
  • Author(s): Hafed Ziad M.、Yoshida Masatoshi、Tian Xiaoguang、Buonocore Antimo、Malevich Tatiana
  • Journal Title: Frontiers in Neural Circuits Volume: 15 Pages: 638429-638429
  • DOI: 10.3389/fncir.2021.638429
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The posterior parietal cortex contributes to visuomotor processing for saccades in blindsight macaques (2021)
  • Author(s): Kato Rikako、Hayashi Takuya、Onoe Kayo、Yoshida Masatoshi、Tsukada Hideo、Onoe Hirotaka、Isa Tadashi、Ikeda Takuro
  • Journal Title: Communications Biology Volume: online ahead of print Issue: 1 Pages: 278-278
  • DOI: 10.1038/s42003-021-01804-z
  • Peer Reviewed / Open Access
• [Journal Article] Opportunities and challenges for a maturing science of consciousness (2019)
  • Author(s): Michel Matthias, Beck Diane, Block Ned,..., Yoshida Masatoshi
  • Journal Title: Nature Human Behaviour Volume: 3 Issue: 2 Pages: 104-107
  • DOI: 10.1038/s41562-019-0531-8
  • Int'l Joint Research
• [Presentation] Deviance detection in visual mismatch negativity (MMN) measured from whole-cortical electrocorticogram (ECoG) arrays in common marmosets (2021)
  • Author(s): Hiroshi Matsui , Misako Komatsu , Takaaki Kaneko , Hideyuki Okano , Noritaka Ichinohe , Masatoshi Yoshida
  • Organizer: 第10回日本マーモセット研究会大会
• [Presentation] Ketamine affects saccadic eye movements during free-viewing, peri-saccadic activity measured from whole-cortical electrocorticogram (ECoG) arrays, and Ca signals in posterior parietal cortex (PPC) in common marmosets (2021)
  • Author(s): Polyakova Zlata , Misako Komatsu , Tetsuo Yamamori , Masatoshi Yoshida
  • Organizer: 第10回日本マーモセット研究会大会
• [Presentation] Microsaccades in blindsight monkeys (2019)
  • Author(s): Masatoshi Yoshida
  • Organizer: Neural Control of Movements
  • Int'l Joint Research
• [Presentation] Visual mismatch negativity measured from whole-cortical electrocorticograhic arrays in common marmosets (2019)
  • Author(s): 吉田正俊
  • Organizer: 日本神経科学学会大会
• [Presentation] 自由エネルギー原理と視覚的意識 (2019)
  • Author(s): 吉田正俊
  • Organizer: 生物基礎論学会
  • Invited
• [Presentation] Comparison of saccadic behavior between common marmosets, macaque monkeys, and humans (2018)
  • Author(s): Chih-Yang Chen
  • Organizer: 第41回日本神経科学大会
• [Presentation] Microsaccades in blindsight monkeys (2018)
  • Author(s): Yoshida M
  • Organizer: Annual meeting of Society for Neuroscience
  • Int'l Joint Research