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Microglia activation induces OPC generation from SVZ under focal demyelination in corpus callosum.

Research Project

Project/Area Number 18K07363
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 51030:Pathophysiologic neuroscience-related
Research InstitutionChiba University (2019-2021)
Gunma University (2018)

Principal Investigator

Naruse Masae  千葉大学, 大学院医学研究院, 特任講師 (60455219)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords神経幹細胞 / オリゴデンドロサイト / 脱髄 / ミクログリア / 髄鞘 / 髄鞘再生 / オリゴデンドロサイト前駆細胞 / 老化
Outline of Final Research Achievements

When demyelination occurs, neural stem or progenitor cells in the SVZ provide newly formed oligodendrocytes to demyelinated lesions. The mechanisms, however, still remain unknown. The present study revealed that focal demyelination in the corpus callosum caused activation of microglia not only at the site of demyelination, but also in the SVZ, and dramatically increased generation of oligodendrocyte progenitor cells (OPCs) in the SVZ. Furthermore, inhibition of microglial activation decreased OPC generation in the SVZ, suggesting that activated microglia in the SVZ, induced by focal demyelination in the corpus callosum, regulate neural stem or progenitor cell lineage plasticity in situ. In contrast, inducing focal demyelination in the internal capsule did not induce either microglial activation or OPC generation in the SVZ. These results suggest that the mechanism of OPC generation in the SVZ following demyelinating lesions could be different among the demyelinated regions.

Academic Significance and Societal Importance of the Research Achievements

内在性の神経幹細胞の活性化による髄鞘再生機構を明らかにする事は、難病である脱髄性疾患の再生医療の解明の発展へ貢献する。また、ミクログリアは脳内の免疫系を担う細胞であるが、近年、生理活性物質を放出して神経細胞やグリア細胞の生存や分化も制御している事が明らかになっている。本課題により、髄鞘再生におけるミクログリアの新しい役割と髄鞘再生過程における神経幹細胞の動態制御機構が明らかになった。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (6 results)

All 2022 2020 2019 2018

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (3 results)

  • [Journal Article] Microglial SIRPα regulates the emergence of CD11c+ microglia and demyelination damage in white matter.2019

    • Author(s)
      Sato-Hashimoto M, Nozu T, Toriba R, Horikoshi A, Akaike M, Kawamoto K, Hirose A, Hayashi H, Nagai H, Shimizu W, Saiki A., Ishikawa T, Elhanbaly R, Kotani T, Murata Y, Saito Y, Naruse M, Shibasaki K, Oldenborg P.-A, Jung S, Matozaki T, Fukazawa Y, Ohnishi H.
    • Journal Title

      eLife

      Volume: - Pages: 1-29

    • DOI

      10.7554/elife.42025

    • NAID

      120006604638

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The dynamics of revascularization after white matter infarction monitored in Flt1-tdsRed and Flk1-GFP mice2019

    • Author(s)
      Shimauchi-Ohtaki Hiroya、Kurachi Masashi、Naruse Masae、Shibasaki Koji、Sugio Shouta、Matsumoto Ken、Ema Masatsugu、Yoshimoto Yuhei、Ishizaki Yasuki
    • Journal Title

      Neuroscience Letters

      Volume: 692 Pages: 70-76

    • DOI

      10.1016/j.neulet.2018.10.057

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microglial activation induces generation of oligodendrocyte progenitor cells from the sub ventricular zone after focal demyelination in the corpus callosum.2018

    • Author(s)
      Naruse M, Shibasaki K, Shimauchi-Ohotaki H, Ishizaki Y
    • Journal Title

      Dev Neurosci

      Volume: 40 Issue: 1 Pages: 54-63

    • DOI

      10.1159/000486332

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] マウス胎仔脳への一過的な遺伝子導入法の開発2022

    • Author(s)
      成瀬雅衣
    • Organizer
      第17回Chiba neuroresearch meeting
    • Related Report
      2021 Annual Research Report
  • [Presentation] 髄鞘損傷時に誘導される活性化ミクログリアによる神経幹細胞運命制御2020

    • Author(s)
      成瀬雅衣
    • Organizer
      第15回 Chiba neuroresearch meeting
    • Related Report
      2019 Research-status Report
  • [Presentation] Microglial activation induces generation of oligodendrocyte progenitor cells from the subventricular zone after focal demyelination in the corpus callosum.2018

    • Author(s)
      成瀬雅衣、柴崎貢志、島内寛也、石崎泰樹
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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