| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The nerve repair signaling following nerve injury may facilitates cancer progression. I previously revealed that Schwann cells were dedifferentiated into immature Schwann cells by cancer cells-induced peripheral nerve injury. In this study, I investigated the role of immature Schwann cells in cancer cells migration/invasion. Conditioned medium from immature Schwann cells significantly enhanced the migration of cancer cells toward the conditioned medium. To explore the collaboration between immature Schwann cells and cancer cells, we developed in vitro coculture system. Immature Schwann cells was associated with cancer cells with their protrusions and formed tunnels. These results suggest that immature Schwann cells dedifferentiated by cancer cells might be a key regulator of cancer cell migration and invasion.
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