Study of Hirosaki Family with dominantly inherited Alzheimer's disease
| Project/Area Number |
18K07385
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 51030:Pathophysiologic neuroscience-related
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| Research Institution | Gunma University (2019-2020)
Hirosaki University (2018) |
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Principal Investigator |
Shoji Mikio 群馬大学, 医学部, 非常勤講師 (60171021)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 常染色体優性遺伝性アルツハイマー病 / バイオマーカー / 脳脊髄液 / 血液 / Abeta / リン酸化タウ / 常染色体優性遺伝アルツハイマー病 |
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| Outline of Final Research Achievements |
Natural course of Alzheimer's disease (AD) of inherited AD Hirosaki families and sporadic Hirosaki cohort was clarified. Clinical Usefulness of CSF and plasma biomarkers were invented and verified. These CSF and plasma biomarkers were Abeta38, Abeta40, Abeta42, Abeta43, total tau, p181tau, p217tau, alpha-synuclein and neurofilament light chain. All these biomarkers were useful for prediction and diagnosis of preclinical AD stages. Association among APOE genotypes, age and Abeta42, amyloid/tau accumulation and cognitive life stale, cognitive disturbance and microbleeds, AD pathology and mRNA were clarified. These results could contribute and facilitate to development of global cohort study and intervention study by novel disease-modifying drugs.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により，遺伝性および孤発例アルツハイマー病の自然経過が明らかにされ，臨床応用に有用なバイオマーカーの基礎的検討と臨床的有用性が示された．今後のAlzheimer病の研究と根本的治療薬開発に大きな貢献をもたらすものと考えられる．
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer's Disease.2020
Author(s)
Pichet Binette A, Vachon-Presseau E, Morris J, Bateman R, Benzinger T, Collins DL, Poirier J, Breitner JCS, Villeneuve S; Dominantly Inherited Alzheimer Network (DIAN); PREVENT-AD Research Group.
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Journal Title
Biol Psychiatry.
Volume: S0006-3223(20)
Issue: 8
Pages: 30058-5
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease.2020
Author(s)
Barthelemy NR, Goate AM, Morris JC, Ikeuchi T, Mori H, Shimada H, Shoji M, Suzuki K, Graff-Radford NR, Salloway S, Masters CL, O'Connor A, Fox NC, Levin J, Jucker M, Gabelle A, Lehmann S, Sato C, Bateman RJ, McDade E; Dominantly Inherited Alzheimer Network ,at al.
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Journal Title
Nat Med.
Volume: 26(3)
Issue: 3
Pages: 398-407
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer's Disease by Peptidome Technology.2020
Author(s)
Abe K, Shang J, Shi X, Yamashita T, Hishikawa N, Takemoto M, Morihara R, Nakano Y, Ohta Y, Deguchi K, Ikeda M, Ikeda Y, Okamoto K, Shoji M, Takatama M, Kojo M, Kuroda T, Ono K, Kimura N, Matsubara E, Osakada Y, Wakutani Y, Takao Y, Higashi Y, Asada K, Senga T, Lee LJ, Tanaka K
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Journal Title
J Alzheimers Dis.
Volume: 73(1)
Issue: 1
Pages: 217-227
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations.2019
Author(s)
Dube U, Del-Aguila JL, Li Z, Budde JP, Jiang S, Hsu S, Ibanez L, Fernandez MV, Farias F, Norton J, Gentsch J, Wang F; Dominantly Inherited Alzheimer Network (DIAN), Salloway S, Masters CL, Lee JH, Graff-Radford NR, Chhatwal JP, Bateman RJ, Morris JC, Karch CM, Harari O, Cruchaga C.
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Journal Title
Nat Neurosci.
Volume: 22(11)
Issue: 11
Pages: 1903-1912
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Oral Immunization with Soybean Storage Protein Containing Amyloid-β 4-10 Prevents Spatial Learning Decline.2019
Author(s)
Kawarabayashi T, Terakawa T, Takahashi A, Hasegawa H, Narita S, Sato K, Nakamura T, Seino Y, Hirohata M, Baba N, Ueda T, Harigaya Y, Kametani F, Maruyama N, Ishimoto M, St George-Hyslop P, Shoji M.
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Journal Title
J Alzheimers Dis.
Volume: 70(2)
Issue: 2
Pages: 487-503
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Book] 新臨床内科学2020
Author(s)
東海林幹夫 （分担）
Total Pages
1960
Publisher
医学書院
ISBN
9784260038065
Related Report
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