What are microglia doing in contact with neurons? -Analysis using a pain model.
| Project/Area Number |
18K07394
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 51030:Pathophysiologic neuroscience-related
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| Research Institution | Niigata University of Health and Welfare (2020-2022)
Kagoshima University (2018-2019) |
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Principal Investigator |
Yasaka Toshiharu 新潟医療福祉大学, リハビリテーション学部, 教授 (20568365)
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| Co-Investigator(Kenkyū-buntansha) |
栗原 崇 鹿児島大学, 医歯学域医学系, 准教授 (60282745)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 神経障害性疼痛 / 脊髄後角 / ミクログリア / 局所神経回路 / インターニューロン / ミクログリ |
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| Outline of Final Research Achievements |
Microglia have been reported to proliferate and activate in the dorsal horn of the spinal cord in animal models of neuropathic pain, and studies have focused on molecules associated with microglia. However, there are few reports on physical contact between neurons and microglia. Since we observed neuron-microglia contacts in the dorsal horn of the spinal cord after nerve injury, we investigated this phenomenon. We observed that these contacts increase after nerve injury. These contacts were observed in both types (excitatory/inhibitory) of neurons in the dorsal horn. Further analysis of this phenomenon may elucidate the pathogenesis of the neuropathic pain.
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| Academic Significance and Societal Importance of the Research Achievements |
神経障害性疼痛は鎮痛薬が効かないこともあり、原因解明と新規治療法の開発が急務である。この病態に関する脊髄後角のミクログリアのこれまでの研究は、ミクログリアを刺激する分子やミクログリアから放出される分子に関するものが中心であった。しかし、今回はニューロンとミクログリアの物理的接触に注目しており、このような研究はほとんど報告されていない。これまでにも多くの研究がなされているにも関わらず、治療につながるような結果があまり得られていない。従って、今回の研究は新しいアプローチであり、新しい視点から病態解明につながるような結果が得られるかもしれない。
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Report
(6 results)
Research Products
(18 results)
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[Journal Article] Essential roles of C-type lectin Mincle in induction of neuropathic pain in mice.2019
Author(s)
Asako Ishikawa, Yasunobu Miyake, Kimiko Kobayashi, Yuzo Murata, Sayaka Iizasa, Ei’ichi Iizasa, Sho Yamasaki, Naomi Hirakawa, Hiromitsu Hara, Hiroki Yoshida, Toshiharu Yasaka
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Journal Title
Scientific Reports
Volume: 9
Issue: 1
Pages: 872-872
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Interleukin-27 controls basal pain threshold in physiological and pathological conditions.2018
Author(s)
Tomoko Sasaguri, Toru Taguchi, Yuzo Murata, Kimiko Kobayashi, Sayaka Iizasa, Ei’ichi Iizasa, Makoto Tsuda, Naomi Hirakawa, Hiromitsu Hara, Hiroki Yoshida, Toshiharu Yasaka
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Journal Title
Scientific Reports
Volume: 8
Issue: 1
Pages: 11022-11022
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Parvalbumin-expressing cells gate a relay providing low-threshold mechanoreceptive input to lamina I projection neurons via vertical cells by the pre- and post-synaptic inhibition in the mouse spinal dorsal horn2019
Author(s)
Toshiharu Yasaka, Kieran A Boyle, Mark A Gradwell, Allen C Dickie, Erika Polgar, Robert P Ganley, Desmond P H Orr, Masahiko Watanabe, Victoria E Abraira, Emily D Kuehn, Amanda L Zimmerman, David D Ginty, Robert J Callister, Brett A Graham, David I Hughes
Organizer
Neuro2019（第42回日本神経科学大会、第62回日本神経化学会大会）
Related Report
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[Presentation] Enhanced basal pain sensitivities observed in mice lacking interleukin-272019
Author(s)
Toshiharu Yasaka, Tomoko Sasaguri, Toru Taguchi, Yuzo Murata, Kimiko Kobayashi, Sayaka Iizasa, Ei’ichi Iizasa, Makoto Tsuda, Naomi Hirakawa, Hiromitsu Hara, Hiroki Yoshida
Organizer
9th FAOPS (Federation of the Asian and Oceanian Physiological Scieties) Congress
Related Report
Int'l Joint Research
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