| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The size of the elderly population of Japan is increasing at an alarming rate and the number of patients suffering from Alzheimer’s disease (AD) is rising in a similarly rapid manner. Elucidation of disease mechanisms and establishment of new strategies to prevent and/or treat and intervene AD are urgently required. Mutations in the PSEN1 gene are known to cause familial AD. In the current project, we generated multiple mouse lines that harbor different Psen1 mutations by genome editing technologies. Production pattern of amyloid-β (Aβ) in the brain was different from that in culture cell models in previous reports. By crossing the mutant Psen1 mice with next generation AD mouse model that was previously developed in our lab, we succeeded in generating new AD mouse model that precisely recapitulates the brain pathology in human AD patients.
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