| Project/Area Number |
18K07435
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52010:General internal medicine-related
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
一迫 玲 東北大学, 大学病院, 教授 (30184625)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 悪性リンパ腫 / 疫学調査 / MYC遺伝子 / 移植後リンパ増殖性疾患 / 濾胞性リンパ腫 / 複合転座 |
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| Outline of Final Research Achievements |
For a diagnosis of DLBCL with MYC translocation, it is critical to perform genetic analysis. We therefore devised a notation that we termed proportion of immunoreactivity/expression for immunohistochemistry based on the cellular proportion showing different antigen-antibody reactivity in immunohistochemistry. The most common notation was "+/(weak)+/-" (49/82 cases [59.8%]); cases that were MYC-IHC positive, weakly positive, and negative for tumor cells each accounted for about one-third of the total and no MYC translocation was observed by FISH. FISH is not needed even if more than half of cells are c-MYC positive by this new notation.
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| Academic Significance and Societal Importance of the Research Achievements |
MYC遺伝子転座を伴うびまん性大細胞型B細胞リンパ腫は、難治性リンパ腫の代表的疾患であり、治療強化が求められている。しかし、病理免疫組織学的検査（免疫染色）では遺伝子転座を確認できず、特殊な遺伝子解析は一部の施設での実施に限定せざるを得ない。今回、新たに免疫染色を用いた客観的な評価基準を作成し、MYC転座と相関することを報告した。一般診療で行われている安価な免疫染色でMYC転座のリスクを層別化できることは、最適な治療選択につながることが期待される。
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