Development of a novel bone quality assessment method for bone morphological deterioration due to sarcopenia in patients with type 2 diabetes mellitus
| Project/Area Number |
18K07446
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52010:General internal medicine-related
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| Research Institution | Shimane University |
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Principal Investigator |
Yamamoto Masahiro 島根大学, 学術研究院医学・看護学系, 准教授 (50346392)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 椎体骨折 / 2型糖尿病 / 脊柱起立筋 / 筋肉量 / 大腿骨近位部骨構造 / 脂肪量 / 椎体微細構造 / 骨質 / 骨構造 / ２型糖尿病 / サルコペニア |
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| Outline of Final Research Achievements |
We constructed a method for determining muscle and fat tissue area in the spinal erector spine muscle group by secondary use of computed tomography images of abdominal area undergone in daily medical practice in the postmenopausal women patients with type 2 diabetes mellitus. Compared to non-fractured subjects, the patients with vertebral fracture had a significantly higher area of fat-containing tissue and a lower region of non-fatty muscle in perirhinal muscle named "back muscles," unlike the counterpart comparison of abdominal erector spinal muscle called the major psoas muscle.
We hope that these findings serve establishment a strategy for the prevention of osteoporosis by enhancing the muscle mass of the perirhinal muscles of the spinal column.
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| Academic Significance and Societal Importance of the Research Achievements |
骨密度で骨強度の評価が困難である2型糖尿病の椎体骨の脆弱性亢進機序において、脊柱周囲筋群の筋量低下や脂肪化との関連を臨床研究により初めて見いだした。筋の脂肪化や筋量喪失は、いわゆる立位姿勢の「前傾化」をもたらし、椎体荷重面が変化して椎体強度低下をもたらす可能性が考えられる。この成果は、2型糖尿病において脊柱起立筋群のサルコペニア化や脂肪化が椎体骨強度の脆弱化の病因である可能性を示唆しており、脊柱周囲筋の筋量増進による骨粗鬆症予防戦略が期待される。
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Report
(5 results)
Research Products
(67 results)
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[Journal Article] A case of insulin-like growth factor 2-producing gastrointestinal stromal tumor with severe hypoglycemia2020
Author(s)
Yamasaki H, Itawaki A, Morita M, Miyake H, Yamamoto M, Sonoyama H, Tanaka S, Notsu M, Yamauchi M, Fujii Y, Ishikawa N, Fukuda I, Ishihara S, Kanasaki K
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Journal Title
BMC Endocr Disord
Volume: 20
Issue: 1
Pages: 60-60
DOI
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Peer Reviewed / Open Access
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[Journal Article] Successful reduction of ACTH secretion in a case of intractable Cushing’s disease with pituitary Crooke’s cell adenoma by combined modality therapy including temozolomide2019
Author(s)
Tanaka S, Yamamoto M, Morita M, Takeno A, Kanazawa I, Yamaguchi T, Yamada S, Inoshita N, Oki Y, Kurosaki M, Sugimoto T.
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Journal Title
Endocrine Journal
Volume: 66
Issue: 8
Pages: 701-708
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed
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[Journal Article] cute suppurative thyroiditis caused by thyroid papillary carcinoma in the right thyroid lobe of a healthy woman.2018
Author(s)
Otani H, Notsu M, Koike S, Morita M, Yamamoto M, Yamauchi M, Fuchiwaki T, Morikura I, Aoi N, Kawauchi H, Iwabashi T, Araki A, Ishikawa N, Maruyama R, Sugimoto T
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Journal Title
Thyroid Res
Volume: 11
Pages: 4-4
Related Report
Peer Reviewed
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[Presentation] HIF-PH阻害薬投与時における酸塩基平衡・電解質変化に関する観察2021
Author(s)
中野里菜, 朝山伊津子, 川北恵美, 石原慎一郎, 和田里美, 田中小百合, 野津雅和, 守田美和, 山本昌弘, 矢野彰三, 金﨑啓造
Organizer
第64回日本腎臓学会年次学術集会
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[Presentation] GNAS遺伝子変異を認めた異所性副腎によるCushing症候群の一例2021
Author(s)
竹谷海, 田中小百合, 山本昌弘, 石原慎一郎, 和田里美, 野津雅和, 守田美和, 竹谷健, 山崎有人, 笹野公伸, 金﨑啓造
Organizer
第31回臨床内分泌代謝Update
Related Report
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