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Predicting Treatment Response of Stress-Related Diseases by Assessing Individual Differences in Synaptic Plasticity

Research Project

Project/Area Number 18K07459
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52010:General internal medicine-related
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

Sekiguchi Atsushi  国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所 行動医学研究部, 室長 (50547289)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsストレス関連疾患 / 脳画像 / 神経可塑性 / 認知訓練 / 認知介入
Outline of Final Research Achievements

Recent brain imaging studies have shown that short-term stimulation by motor learning, cognitive training, magnetic stimulation (TMS), and electrical stimulation (tDCS) can alter brain function and brain morphology. These changes in brain morphology have been discussed as the basis for synaptic plasticity in adults. Reduced synaptic plasticity has been reported to be a risk factor for dementia and a predictor of recovery from stressful stressors, and may serve as an objective biomarker for assessing disease risk.
In this study, we aimed to evaluate and validate brain MR imaging changes induced by short-term cognitive intervention as synaptic plasticity.

Academic Significance and Societal Importance of the Research Achievements

本共同研究が今後発展することにより、短期的刺激によるシナプス可塑性の個人差を検出し、精神疾患の危険因子のバイオマーカーとなりえることを明らかにできると見込まれる。更に、ストレス関連疾患の患者群への同様の検討を行うことで、短期的な認知的刺激によるシナプス可塑性指標が、認知行動療法や薬物療法などの治療反応性を予測する因子となる可能性を検討する。中長期的な展望としては、より簡便な介入検査により、疾患リスクや治療反応性を予測できることができ、精神医療への多大なる貢献が見込まれる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2022 2021 2020 2019 2018

All Journal Article (3 results) (of which Open Access: 2 results,  Peer Reviewed: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Journal Article] 「脳」と「身体」と「行動変容」2022

    • Author(s)
      関口 敦,菅原彩子,勝沼るり,寺澤悠理
    • Journal Title

      心身医学

      Volume: 62 Pages: 225-229

    • Related Report
      2021 Annual Research Report
    • Open Access
  • [Journal Article] Neuroimaging Evaluation of Pathology Model of a Central Sensitization2021

    • Author(s)
      関口敦
    • Journal Title

      Japanese Journal of Psychosomatic Medicine

      Volume: 61 Issue: 2 Pages: 165-171

    • DOI

      10.15064/jjpm.61.2_165

    • NAID

      130007993526

    • ISSN
      0385-0307, 2189-5996
    • Related Report
      2020 Research-status Report
  • [Journal Article] Effects of interoceptive training on decision making, anxiety, and somatic symptoms2020

    • Author(s)
      Sugawara A. Terasawa Y, Katsunuma R, Sekiguchi A
    • Journal Title

      BioPsychoSocial Medicine

      Volume: 14 Issue: 1 Pages: 7-7

    • DOI

      10.1186/s13030-020-00179-7

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 「脳」と「身体」と「行動変容」2021

    • Author(s)
      関口 敦,菅原彩子,勝沼るり,寺澤悠理
    • Organizer
      第62回日本心身医学会総会ならびに学術講演会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 失体感と脳科学2019

    • Author(s)
      関口敦
    • Organizer
      〈身〉の医療研究会 第5回研究交流会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Neural underpinning of interoceptive dysfunction, and an effect of interoceptive training.2019

    • Author(s)
      Sugawara A, Terasawa Y, Katsunuma R, Sekiguchi A
    • Organizer
      The 25tn World Congress of the International college of psychosomatic medicine
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脳画像研究で検証する中枢神経感作病態2019

    • Author(s)
      関口敦
    • Organizer
      第2回日本心身医学関連学会合同集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Neural underpinnings of an effect of interoceptive training on decision making processing2018

    • Author(s)
      Sekiguchi A, Sugawara A, Terasawa Y
    • Organizer
      The 77th Annual Meeting of the American Psychosomatic Society
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2023-01-30  

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